IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibition Article Swipe
Lucien Courtois
,
Aurélie Cabannes‐Hamy
,
Rathana Kim
,
Marine Delecourt
,
Antoine Pinton
,
Guillaume Charbonnier
,
Mélanie Féroul
,
Charlotte Smith
,
Giulia Tueur
,
Cecile Pivert
,
Estelle Balducci
,
Mathieu Simonin
,
Laure Hélène Angel
,
Salvatore Spicuglia
,
Nicolas Boissel
,
Guillaume P. Andrieu
,
Vahid Asnafi
,
Philippe Rousselot
,
Ludovic Lhermitte
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1182/blood.2022017948
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1182/blood.2022017948
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis related to refractory/relapsing diseases, raising the need for new targeted-therapies. Activating mutations of the IL7-receptor pathway genes (IL7Rp) play a proven leukemia-supportive role in T-ALL. JAK-inhibitors such as ruxolitinib have recently demonstrated preclinical efficacy. However, prediction markers for sensitivity to JAK-inhibitors are still lacking. Herein, we show that IL7R (CD127) expression is more frequent (~70%) than IL7Rp-mutations in T-ALL (~30%). We compared the so-called non-expressers (no IL7R-expression/IL7Rp-mutation), expressers (IL7R-expression without IL7Rp-mutation) and mutants (IL7Rp-mutations). Integrative multi-omics analysis outlined IL7R-deregulation in virtually all T-ALL subtypes, at the epigenetic-level in non-expressers, genetic-level in mutants, and post-transcriptional level in expressers. Ex-vivo data using primary-derived xenografts support that IL7Rp is functional whenever the IL7R is expressed, regardless of the IL7Rp mutational status. Consequently, ruxolitinib impaired T-ALL survival in both expressers and mutants. Interestingly, we show that expressers displayed ectopic IL7R-expression and IL7Rp-addiction conferring a deeper sensitivity to ruxolitinib. Conversely, mutants were more sensitive to venetoclax than expressers. Overall, combination of ruxolitinib and venetoclax resulted in synergistic effects in both groups. We illustrate the clinical relevance of this association by reporting achievement of complete remission in two patients with refractory/relapsed-T-ALL. This provides proof of concept for translation of this strategy into clinics as bridge to transplant. Altogether, IL7R-expression can be used as a biomarker for sensitivity to JAK-inhibition, thereby expanding the fraction of T-ALL patients eligible to ruxolitinib up to nearly ~70% of T-ALL.
Related Topics
Concepts
Biology
Interleukin-7 receptor
Ruxolitinib
Somatic evolution in cancer
Cancer research
Oncology
Internal medicine
Immunology
Genetics
Medicine
T cell
Cancer
Bone marrow
Immune system
Myelofibrosis
IL-2 receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1182/blood.2022017948
- https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdf
- OA Status
- bronze
- Cited By
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362676602
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4362676602Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1182/blood.2022017948Digital Object Identifier
- Title
-
IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibitionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-06Full publication date if available
- Authors
-
Lucien Courtois, Aurélie Cabannes‐Hamy, Rathana Kim, Marine Delecourt, Antoine Pinton, Guillaume Charbonnier, Mélanie Féroul, Charlotte Smith, Giulia Tueur, Cecile Pivert, Estelle Balducci, Mathieu Simonin, Laure Hélène Angel, Salvatore Spicuglia, Nicolas Boissel, Guillaume P. Andrieu, Vahid Asnafi, Philippe Rousselot, Ludovic LhermitteList of authors in order
- Landing page
-
https://doi.org/10.1182/blood.2022017948Publisher landing page
- PDF URL
-
https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdfDirect OA link when available
- Concepts
-
Biology, Interleukin-7 receptor, Ruxolitinib, Somatic evolution in cancer, Cancer research, Oncology, Internal medicine, Immunology, Genetics, Medicine, T cell, Cancer, Bone marrow, Immune system, Myelofibrosis, IL-2 receptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
27Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 13, 2024: 12, 2023: 2Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4362676602 |
|---|---|
| doi | https://doi.org/10.1182/blood.2022017948 |
| ids.doi | https://doi.org/10.1182/blood.2022017948 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37023368 |
| ids.openalex | https://openalex.org/W4362676602 |
| fwci | 12.78896634 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D020395 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Receptors, Interleukin-7 |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D020395 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Receptors, Interleukin-7 |
| mesh[3].qualifier_ui | Q000188 |
| mesh[3].descriptor_ui | D054218 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug therapy |
| mesh[3].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D054218 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D054218 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[6].qualifier_ui | Q000627 |
| mesh[6].descriptor_ui | D000075242 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | therapeutic use |
| mesh[6].descriptor_name | Janus Kinase Inhibitors |
| mesh[7].qualifier_ui | Q000473 |
| mesh[7].descriptor_ui | D013601 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pathology |
| mesh[7].descriptor_name | T-Lymphocytes |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D020395 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Receptors, Interleukin-7 |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D020395 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Receptors, Interleukin-7 |
| mesh[11].qualifier_ui | Q000188 |
| mesh[11].descriptor_ui | D054218 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | drug therapy |
| mesh[11].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D054218 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D054218 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[14].qualifier_ui | Q000627 |
| mesh[14].descriptor_ui | D000075242 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | therapeutic use |
| mesh[14].descriptor_name | Janus Kinase Inhibitors |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D013601 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | T-Lymphocytes |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D020395 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Receptors, Interleukin-7 |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D020395 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Receptors, Interleukin-7 |
| mesh[19].qualifier_ui | Q000188 |
| mesh[19].descriptor_ui | D054218 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | drug therapy |
| mesh[19].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D054218 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[21].qualifier_ui | Q000378 |
| mesh[21].descriptor_ui | D054218 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | metabolism |
| mesh[21].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[22].qualifier_ui | Q000627 |
| mesh[22].descriptor_ui | D000075242 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | therapeutic use |
| mesh[22].descriptor_name | Janus Kinase Inhibitors |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D013601 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | T-Lymphocytes |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D020395 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Receptors, Interleukin-7 |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D020395 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Receptors, Interleukin-7 |
| mesh[27].qualifier_ui | Q000188 |
| mesh[27].descriptor_ui | D054218 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug therapy |
| mesh[27].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D054218 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D054218 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma |
| mesh[30].qualifier_ui | Q000627 |
| mesh[30].descriptor_ui | D000075242 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | therapeutic use |
| mesh[30].descriptor_name | Janus Kinase Inhibitors |
| mesh[31].qualifier_ui | Q000473 |
| mesh[31].descriptor_ui | D013601 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pathology |
| mesh[31].descriptor_name | T-Lymphocytes |
| type | article |
| title | IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibition |
| biblio.issue | 2 |
| biblio.volume | 142 |
| biblio.last_page | 171 |
| biblio.first_page | 158 |
| topics[0].id | https://openalex.org/T10950 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2739 |
| topics[0].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[0].display_name | Acute Lymphoblastic Leukemia research |
| topics[1].id | https://openalex.org/T11215 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9941999912261963 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2720 |
| topics[1].subfield.display_name | Hematology |
| topics[1].display_name | Chronic Myeloid Leukemia Treatments |
| topics[2].id | https://openalex.org/T10185 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9927999973297119 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2734 |
| topics[2].subfield.display_name | Pathology and Forensic Medicine |
| topics[2].display_name | Lymphoma Diagnosis and Treatment |
| is_xpac | False |
| apc_list.value | 5000 |
| apc_list.currency | USD |
| apc_list.value_usd | 5000 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.5665795207023621 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C123982805 |
| concepts[1].level | 5 |
| concepts[1].score | 0.4894822835922241 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q6046964 |
| concepts[1].display_name | Interleukin-7 receptor |
| concepts[2].id | https://openalex.org/C2776112149 |
| concepts[2].level | 4 |
| concepts[2].score | 0.4421396553516388 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7383611 |
| concepts[2].display_name | Ruxolitinib |
| concepts[3].id | https://openalex.org/C113968399 |
| concepts[3].level | 3 |
| concepts[3].score | 0.43655940890312195 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7559241 |
| concepts[3].display_name | Somatic evolution in cancer |
| concepts[4].id | https://openalex.org/C502942594 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4292256236076355 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[4].display_name | Cancer research |
| concepts[5].id | https://openalex.org/C143998085 |
| concepts[5].level | 1 |
| concepts[5].score | 0.40535056591033936 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[5].display_name | Oncology |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.32290536165237427 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.2820173501968384 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.24510177969932556 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.21818765997886658 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C2776090121 |
| concepts[10].level | 3 |
| concepts[10].score | 0.17024028301239014 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q193529 |
| concepts[10].display_name | T cell |
| concepts[11].id | https://openalex.org/C121608353 |
| concepts[11].level | 2 |
| concepts[11].score | 0.14476501941680908 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[11].display_name | Cancer |
| concepts[12].id | https://openalex.org/C2780007613 |
| concepts[12].level | 2 |
| concepts[12].score | 0.07080653309822083 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q546523 |
| concepts[12].display_name | Bone marrow |
| concepts[13].id | https://openalex.org/C8891405 |
| concepts[13].level | 2 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[13].display_name | Immune system |
| concepts[14].id | https://openalex.org/C2780076729 |
| concepts[14].level | 3 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q1752571 |
| concepts[14].display_name | Myelofibrosis |
| concepts[15].id | https://openalex.org/C79484868 |
| concepts[15].level | 4 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q5971673 |
| concepts[15].display_name | IL-2 receptor |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.5665795207023621 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/interleukin-7-receptor |
| keywords[1].score | 0.4894822835922241 |
| keywords[1].display_name | Interleukin-7 receptor |
| keywords[2].id | https://openalex.org/keywords/ruxolitinib |
| keywords[2].score | 0.4421396553516388 |
| keywords[2].display_name | Ruxolitinib |
| keywords[3].id | https://openalex.org/keywords/somatic-evolution-in-cancer |
| keywords[3].score | 0.43655940890312195 |
| keywords[3].display_name | Somatic evolution in cancer |
| keywords[4].id | https://openalex.org/keywords/cancer-research |
| keywords[4].score | 0.4292256236076355 |
| keywords[4].display_name | Cancer research |
| keywords[5].id | https://openalex.org/keywords/oncology |
| keywords[5].score | 0.40535056591033936 |
| keywords[5].display_name | Oncology |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.32290536165237427 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.2820173501968384 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.24510177969932556 |
| keywords[8].display_name | Genetics |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.21818765997886658 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/t-cell |
| keywords[10].score | 0.17024028301239014 |
| keywords[10].display_name | T cell |
| keywords[11].id | https://openalex.org/keywords/cancer |
| keywords[11].score | 0.14476501941680908 |
| keywords[11].display_name | Cancer |
| keywords[12].id | https://openalex.org/keywords/bone-marrow |
| keywords[12].score | 0.07080653309822083 |
| keywords[12].display_name | Bone marrow |
| language | en |
| locations[0].id | doi:10.1182/blood.2022017948 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S200071133 |
| locations[0].source.issn | 0006-4971, 1528-0020 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0006-4971 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Blood |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | |
| locations[0].pdf_url | https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Blood |
| locations[0].landing_page_url | https://doi.org/10.1182/blood.2022017948 |
| locations[1].id | pmid:37023368 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Blood |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37023368 |
| locations[2].id | pmh:oai:HAL:hal-04191646v1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Blood, 2023, 142 (2), pp.158-171. ⟨10.1182/blood.2022017948⟩ |
| locations[2].landing_page_url | https://hal.science/hal-04191646 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5031261793 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4156-3008 |
| authorships[0].author.display_name | Lucien Courtois |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210086369 |
| authorships[0].affiliations[0].raw_affiliation_string | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[0].institutions[0].id | https://openalex.org/I154526488 |
| authorships[0].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Inserm |
| authorships[0].institutions[1].id | https://openalex.org/I4210086369 |
| authorships[0].institutions[1].ror | https://ror.org/000nhq538 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Institut Necker Enfants Malades |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Lucien Courtois |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[1].author.id | https://openalex.org/A5086254154 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6064-3783 |
| authorships[1].author.display_name | Aurélie Cabannes‐Hamy |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210159263 |
| authorships[1].affiliations[0].raw_affiliation_string | Centre Hospitalier de Versailles, Le Chesnay, France |
| authorships[1].institutions[0].id | https://openalex.org/I4210159263 |
| authorships[1].institutions[0].ror | https://ror.org/053evvt91 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210159263 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre Hospitalier de Versailles |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Aurelie Cabannes-Hamy |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Centre Hospitalier de Versailles, Le Chesnay, France |
| authorships[2].author.id | https://openalex.org/A5037286573 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9987-7237 |
| authorships[2].author.display_name | Rathana Kim |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210097159, https://openalex.org/I4210144610 |
| authorships[2].affiliations[0].raw_affiliation_string | AP-HP - Hopital Saint-Louis [AP-HP] (1 Avenue Claude Vellefaux, 75010 Paris - France) |
| authorships[2].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[2].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[2].institutions[1].id | https://openalex.org/I4210144610 |
| authorships[2].institutions[1].ror | https://ror.org/049am9t04 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210097159, https://openalex.org/I4210144610 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Hôpital Saint-Louis |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rathana Kim |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | AP-HP - Hopital Saint-Louis [AP-HP] (1 Avenue Claude Vellefaux, 75010 Paris - France) |
| authorships[3].author.id | https://openalex.org/A5024312576 |
| authorships[3].author.orcid | https://orcid.org/0009-0007-9017-9516 |
| authorships[3].author.display_name | Marine Delecourt |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[3].affiliations[0].raw_affiliation_string | APHP Hopital Necker Enfants Malades, Paris, France |
| authorships[3].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[3].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[3].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[3].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Marine Delecourt |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | APHP Hopital Necker Enfants Malades, Paris, France |
| authorships[4].author.id | https://openalex.org/A5035109792 |
| authorships[4].author.orcid | https://orcid.org/0009-0002-2801-6824 |
| authorships[4].author.display_name | Antoine Pinton |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210086369 |
| authorships[4].affiliations[0].raw_affiliation_string | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[4].institutions[0].id | https://openalex.org/I154526488 |
| authorships[4].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Inserm |
| authorships[4].institutions[1].id | https://openalex.org/I4210086369 |
| authorships[4].institutions[1].ror | https://ror.org/000nhq538 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Institut Necker Enfants Malades |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Antoine Pinton |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[5].author.id | https://openalex.org/A5104519974 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5615-1287 |
| authorships[5].author.display_name | Guillaume Charbonnier |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1288880153 |
| authorships[5].affiliations[0].raw_affiliation_string | Hopital Necker Enfants-Malades, Paris, France |
| authorships[5].institutions[0].id | https://openalex.org/I1288880153 |
| authorships[5].institutions[0].ror | https://ror.org/05tr67282 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Hôpital Necker-Enfants Malades |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Guillaume Charbonnier |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Hopital Necker Enfants-Malades, Paris, France |
| authorships[6].author.id | https://openalex.org/A5033072030 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Mélanie Féroul |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[6].affiliations[0].raw_affiliation_string | Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France |
| authorships[6].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[6].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[6].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[6].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mélanie Féroul |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France |
| authorships[7].author.id | https://openalex.org/A5069499304 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7209-9287 |
| authorships[7].author.display_name | Charlotte Smith |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210086369 |
| authorships[7].affiliations[0].raw_affiliation_string | Institut Necker Enfants Malades, Paris, France |
| authorships[7].institutions[0].id | https://openalex.org/I4210086369 |
| authorships[7].institutions[0].ror | https://ror.org/000nhq538 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Institut Necker Enfants Malades |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Charlotte Smith |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institut Necker Enfants Malades, Paris, France |
| authorships[8].author.id | https://openalex.org/A5059468087 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Giulia Tueur |
| authorships[8].countries | FR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[8].affiliations[0].raw_affiliation_string | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[8].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[8].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[8].institutions[0].country_code | FR |
| authorships[8].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[8].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[8].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[8].institutions[1].country_code | FR |
| authorships[8].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Giulia Tueur |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[9].author.id | https://openalex.org/A5040592419 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Cecile Pivert |
| authorships[9].countries | FR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[9].affiliations[0].raw_affiliation_string | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[9].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[9].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[9].institutions[0].country_code | FR |
| authorships[9].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[9].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[9].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[9].institutions[1].country_code | FR |
| authorships[9].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Cecile Pivert |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[10].author.id | https://openalex.org/A5059743121 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-6792-1291 |
| authorships[10].author.display_name | Estelle Balducci |
| authorships[10].countries | FR |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[10].affiliations[0].raw_affiliation_string | Hôpital Necker-Enfants Malades, APHP, Paris, France |
| authorships[10].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[10].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[10].institutions[0].country_code | FR |
| authorships[10].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[10].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[10].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[10].institutions[1].country_code | FR |
| authorships[10].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Estelle Balducci |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Hôpital Necker-Enfants Malades, APHP, Paris, France |
| authorships[11].author.id | https://openalex.org/A5037596808 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0448-8811 |
| authorships[11].author.display_name | Mathieu Simonin |
| authorships[11].countries | FR |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210086369 |
| authorships[11].affiliations[0].raw_affiliation_string | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[11].institutions[0].id | https://openalex.org/I154526488 |
| authorships[11].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[11].institutions[0].type | government |
| authorships[11].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[11].institutions[0].country_code | FR |
| authorships[11].institutions[0].display_name | Inserm |
| authorships[11].institutions[1].id | https://openalex.org/I4210086369 |
| authorships[11].institutions[1].ror | https://ror.org/000nhq538 |
| authorships[11].institutions[1].type | facility |
| authorships[11].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[11].institutions[1].country_code | FR |
| authorships[11].institutions[1].display_name | Institut Necker Enfants Malades |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Mathieu Simonin |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[12].author.id | https://openalex.org/A5043086208 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Laure Hélène Angel |
| authorships[12].countries | FR |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[12].affiliations[0].raw_affiliation_string | Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France, Paris, Alabama, France |
| authorships[12].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[12].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[12].institutions[0].country_code | FR |
| authorships[12].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[12].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[12].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[12].institutions[1].country_code | FR |
| authorships[12].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Laure Hélène Angel |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France, Paris, Alabama, France |
| authorships[13].author.id | https://openalex.org/A5091488339 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-8101-7108 |
| authorships[13].author.display_name | Salvatore Spicuglia |
| authorships[13].countries | FR |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210112918 |
| authorships[13].affiliations[0].raw_affiliation_string | TAGC - Theories and Approaches of Genomic Complexity (Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9 - France) |
| authorships[13].institutions[0].id | https://openalex.org/I4210112918 |
| authorships[13].institutions[0].ror | https://ror.org/025sfbe73 |
| authorships[13].institutions[0].type | facility |
| authorships[13].institutions[0].lineage | https://openalex.org/I154526488, https://openalex.org/I21491767, https://openalex.org/I4210112918 |
| authorships[13].institutions[0].country_code | FR |
| authorships[13].institutions[0].display_name | Theories and Approaches of Genomic Complexity |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Salvatore Spicuglia |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | TAGC - Theories and Approaches of Genomic Complexity (Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9 - France) |
| authorships[14].author.id | https://openalex.org/A5076973611 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-2091-7927 |
| authorships[14].author.display_name | Nicolas Boissel |
| authorships[14].countries | FR |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210097159, https://openalex.org/I4210144610 |
| authorships[14].affiliations[0].raw_affiliation_string | AP-HP - Hopital Saint-Louis [AP-HP] (1 Avenue Claude Vellefaux, 75010 Paris - France) |
| authorships[14].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[14].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[14].institutions[0].country_code | FR |
| authorships[14].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[14].institutions[1].id | https://openalex.org/I4210144610 |
| authorships[14].institutions[1].ror | https://ror.org/049am9t04 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210097159, https://openalex.org/I4210144610 |
| authorships[14].institutions[1].country_code | FR |
| authorships[14].institutions[1].display_name | Hôpital Saint-Louis |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Nicolas Boissel |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | AP-HP - Hopital Saint-Louis [AP-HP] (1 Avenue Claude Vellefaux, 75010 Paris - France) |
| authorships[15].author.id | https://openalex.org/A5057234657 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-0289-4952 |
| authorships[15].author.display_name | Guillaume P. Andrieu |
| authorships[15].countries | FR |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210086369 |
| authorships[15].affiliations[0].raw_affiliation_string | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[15].institutions[0].id | https://openalex.org/I154526488 |
| authorships[15].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[15].institutions[0].type | government |
| authorships[15].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[15].institutions[0].country_code | FR |
| authorships[15].institutions[0].display_name | Inserm |
| authorships[15].institutions[1].id | https://openalex.org/I4210086369 |
| authorships[15].institutions[1].ror | https://ror.org/000nhq538 |
| authorships[15].institutions[1].type | facility |
| authorships[15].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[15].institutions[1].country_code | FR |
| authorships[15].institutions[1].display_name | Institut Necker Enfants Malades |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Guillaume P Andrieu |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Institut Necker Enfants-Malades, INSERM U1151, Paris, France |
| authorships[16].author.id | https://openalex.org/A5046761978 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-6255-5314 |
| authorships[16].author.display_name | Vahid Asnafi |
| authorships[16].countries | FR |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[16].affiliations[0].raw_affiliation_string | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[16].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[16].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[16].institutions[0].type | healthcare |
| authorships[16].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[16].institutions[0].country_code | FR |
| authorships[16].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[16].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[16].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[16].institutions[1].type | healthcare |
| authorships[16].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[16].institutions[1].country_code | FR |
| authorships[16].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Vahid Asnafi |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[17].author.id | https://openalex.org/A5052564121 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-3238-4494 |
| authorships[17].author.display_name | Philippe Rousselot |
| authorships[17].countries | FR |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I4210159263 |
| authorships[17].affiliations[0].raw_affiliation_string | Centre Hospitalier de Versailles, Le Chesnay, France |
| authorships[17].institutions[0].id | https://openalex.org/I4210159263 |
| authorships[17].institutions[0].ror | https://ror.org/053evvt91 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I4210159263 |
| authorships[17].institutions[0].country_code | FR |
| authorships[17].institutions[0].display_name | Centre Hospitalier de Versailles |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Philippe Rousselot |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Centre Hospitalier de Versailles, Le Chesnay, France |
| authorships[18].author.id | https://openalex.org/A5067808997 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-2498-0376 |
| authorships[18].author.display_name | Ludovic Lhermitte |
| authorships[18].countries | FR |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I1288880153, https://openalex.org/I4210097159 |
| authorships[18].affiliations[0].raw_affiliation_string | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| authorships[18].institutions[0].id | https://openalex.org/I4210097159 |
| authorships[18].institutions[0].ror | https://ror.org/00pg5jh14 |
| authorships[18].institutions[0].type | healthcare |
| authorships[18].institutions[0].lineage | https://openalex.org/I4210097159 |
| authorships[18].institutions[0].country_code | FR |
| authorships[18].institutions[0].display_name | Assistance Publique – Hôpitaux de Paris |
| authorships[18].institutions[1].id | https://openalex.org/I1288880153 |
| authorships[18].institutions[1].ror | https://ror.org/05tr67282 |
| authorships[18].institutions[1].type | healthcare |
| authorships[18].institutions[1].lineage | https://openalex.org/I1288880153, https://openalex.org/I4210097159, https://openalex.org/I4210120235 |
| authorships[18].institutions[1].country_code | FR |
| authorships[18].institutions[1].display_name | Hôpital Necker-Enfants Malades |
| authorships[18].author_position | last |
| authorships[18].raw_author_name | Ludovic Lhermitte |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Hôpital Necker Enfants-Malades, Laboratoire d'Onco-Hématologie, Assistance Publique-Hôpitaux de Paris (AP-HP), France |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibition |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10950 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2739 |
| primary_topic.subfield.display_name | Public Health, Environmental and Occupational Health |
| primary_topic.display_name | Acute Lymphoblastic Leukemia research |
| related_works | https://openalex.org/W1582185909, https://openalex.org/W3016444371, https://openalex.org/W3076180738, https://openalex.org/W4366603286, https://openalex.org/W3035765027, https://openalex.org/W2129899732, https://openalex.org/W2184879058, https://openalex.org/W2887049930, https://openalex.org/W2092462163, https://openalex.org/W2752073795 |
| cited_by_count | 27 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 13 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 12 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1182/blood.2022017948 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S200071133 |
| best_oa_location.source.issn | 0006-4971, 1528-0020 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0006-4971 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Blood |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Blood |
| best_oa_location.landing_page_url | https://doi.org/10.1182/blood.2022017948 |
| primary_location.id | doi:10.1182/blood.2022017948 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S200071133 |
| primary_location.source.issn | 0006-4971, 1528-0020 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0006-4971 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Blood |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | |
| primary_location.pdf_url | https://ashpublications.org/blood/article-pdf/142/2/158/2062650/blood_bld-2022-017948-main.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Blood |
| primary_location.landing_page_url | https://doi.org/10.1182/blood.2022017948 |
| publication_date | 2023-04-06 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.a | 11, 33, 153, 221 |
| abstract_inverted_index.We | 74, 180 |
| abstract_inverted_index.an | 6 |
| abstract_inverted_index.as | 41, 211, 220 |
| abstract_inverted_index.at | 98 |
| abstract_inverted_index.be | 218 |
| abstract_inverted_index.by | 188 |
| abstract_inverted_index.in | 37, 71, 93, 101, 104, 109, 137, 174, 177, 194 |
| abstract_inverted_index.is | 5, 65, 119, 124 |
| abstract_inverted_index.of | 26, 127, 169, 185, 191, 202, 206, 231, 241 |
| abstract_inverted_index.to | 15, 53, 156, 163, 213, 225, 235, 238 |
| abstract_inverted_index.up | 237 |
| abstract_inverted_index.we | 59, 143 |
| abstract_inverted_index.(no | 79 |
| abstract_inverted_index.all | 95 |
| abstract_inverted_index.and | 85, 106, 140, 150, 171 |
| abstract_inverted_index.are | 55 |
| abstract_inverted_index.can | 217 |
| abstract_inverted_index.for | 21, 51, 204, 223 |
| abstract_inverted_index.new | 22 |
| abstract_inverted_index.the | 19, 27, 76, 99, 122, 128, 182, 229 |
| abstract_inverted_index.two | 195 |
| abstract_inverted_index.IL7R | 62, 123 |
| abstract_inverted_index.This | 199 |
| abstract_inverted_index.both | 138, 178 |
| abstract_inverted_index.data | 112 |
| abstract_inverted_index.have | 43 |
| abstract_inverted_index.into | 209 |
| abstract_inverted_index.more | 66, 161 |
| abstract_inverted_index.need | 20 |
| abstract_inverted_index.play | 32 |
| abstract_inverted_index.role | 36 |
| abstract_inverted_index.show | 60, 144 |
| abstract_inverted_index.such | 40 |
| abstract_inverted_index.than | 69, 165 |
| abstract_inverted_index.that | 61, 117, 145 |
| abstract_inverted_index.this | 186, 207 |
| abstract_inverted_index.used | 219 |
| abstract_inverted_index.were | 160 |
| abstract_inverted_index.with | 10, 197 |
| abstract_inverted_index.~70% | 240 |
| abstract_inverted_index.IL7Rp | 118, 129 |
| abstract_inverted_index.T-ALL | 72, 96, 135, 232 |
| abstract_inverted_index.acute | 1 |
| abstract_inverted_index.genes | 30 |
| abstract_inverted_index.level | 108 |
| abstract_inverted_index.proof | 201 |
| abstract_inverted_index.still | 56 |
| abstract_inverted_index.using | 113 |
| abstract_inverted_index.(~70%) | 68 |
| abstract_inverted_index.T-ALL. | 38, 242 |
| abstract_inverted_index.T-cell | 0 |
| abstract_inverted_index.bridge | 212 |
| abstract_inverted_index.deeper | 154 |
| abstract_inverted_index.dismal | 12 |
| abstract_inverted_index.nearly | 239 |
| abstract_inverted_index.proven | 34 |
| abstract_inverted_index.(CD127) | 63 |
| abstract_inverted_index.(IL7Rp) | 31 |
| abstract_inverted_index.(T-ALL) | 4 |
| abstract_inverted_index.(~30%). | 73 |
| abstract_inverted_index.Ex-vivo | 111 |
| abstract_inverted_index.Herein, | 58 |
| abstract_inverted_index.clinics | 210 |
| abstract_inverted_index.concept | 203 |
| abstract_inverted_index.ectopic | 148 |
| abstract_inverted_index.effects | 176 |
| abstract_inverted_index.groups. | 179 |
| abstract_inverted_index.markers | 50 |
| abstract_inverted_index.mutants | 86, 159 |
| abstract_inverted_index.pathway | 29 |
| abstract_inverted_index.raising | 18 |
| abstract_inverted_index.related | 14 |
| abstract_inverted_index.status. | 131 |
| abstract_inverted_index.support | 116 |
| abstract_inverted_index.thereby | 227 |
| abstract_inverted_index.without | 83 |
| abstract_inverted_index.However, | 48 |
| abstract_inverted_index.Overall, | 167 |
| abstract_inverted_index.analysis | 90 |
| abstract_inverted_index.clinical | 183 |
| abstract_inverted_index.compared | 75 |
| abstract_inverted_index.complete | 192 |
| abstract_inverted_index.eligible | 234 |
| abstract_inverted_index.fraction | 230 |
| abstract_inverted_index.frequent | 67 |
| abstract_inverted_index.impaired | 134 |
| abstract_inverted_index.lacking. | 57 |
| abstract_inverted_index.leukemia | 3 |
| abstract_inverted_index.mutants, | 105 |
| abstract_inverted_index.mutants. | 141 |
| abstract_inverted_index.outlined | 91 |
| abstract_inverted_index.patients | 196, 233 |
| abstract_inverted_index.provides | 200 |
| abstract_inverted_index.recently | 44 |
| abstract_inverted_index.resulted | 173 |
| abstract_inverted_index.strategy | 208 |
| abstract_inverted_index.survival | 136 |
| abstract_inverted_index.whenever | 121 |
| abstract_inverted_index.biomarker | 222 |
| abstract_inverted_index.diseases, | 17 |
| abstract_inverted_index.displayed | 147 |
| abstract_inverted_index.efficacy. | 47 |
| abstract_inverted_index.expanding | 228 |
| abstract_inverted_index.mutations | 25 |
| abstract_inverted_index.prognosis | 13 |
| abstract_inverted_index.relevance | 184 |
| abstract_inverted_index.remission | 193 |
| abstract_inverted_index.reporting | 189 |
| abstract_inverted_index.sensitive | 162 |
| abstract_inverted_index.so-called | 77 |
| abstract_inverted_index.subtypes, | 97 |
| abstract_inverted_index.virtually | 94 |
| abstract_inverted_index.Activating | 24 |
| abstract_inverted_index.aggressive | 7 |
| abstract_inverted_index.conferring | 152 |
| abstract_inverted_index.expressed, | 125 |
| abstract_inverted_index.expressers | 81, 139, 146 |
| abstract_inverted_index.expression | 64 |
| abstract_inverted_index.functional | 120 |
| abstract_inverted_index.illustrate | 181 |
| abstract_inverted_index.malignancy | 9 |
| abstract_inverted_index.mutational | 130 |
| abstract_inverted_index.prediction | 49 |
| abstract_inverted_index.regardless | 126 |
| abstract_inverted_index.venetoclax | 164, 172 |
| abstract_inverted_index.xenografts | 115 |
| abstract_inverted_index.Altogether, | 215 |
| abstract_inverted_index.Conversely, | 158 |
| abstract_inverted_index.Integrative | 88 |
| abstract_inverted_index.achievement | 190 |
| abstract_inverted_index.association | 187 |
| abstract_inverted_index.combination | 168 |
| abstract_inverted_index.expressers. | 110, 166 |
| abstract_inverted_index.multi-omics | 89 |
| abstract_inverted_index.preclinical | 46 |
| abstract_inverted_index.ruxolitinib | 42, 133, 170, 236 |
| abstract_inverted_index.sensitivity | 52, 155, 224 |
| abstract_inverted_index.synergistic | 175 |
| abstract_inverted_index.translation | 205 |
| abstract_inverted_index.transplant. | 214 |
| abstract_inverted_index.IL7-receptor | 28 |
| abstract_inverted_index.demonstrated | 45 |
| abstract_inverted_index.ruxolitinib. | 157 |
| abstract_inverted_index.Consequently, | 132 |
| abstract_inverted_index.genetic-level | 103 |
| abstract_inverted_index.hematological | 8 |
| abstract_inverted_index.lymphoblastic | 2 |
| abstract_inverted_index.Interestingly, | 142 |
| abstract_inverted_index.JAK-inhibitors | 39, 54 |
| abstract_inverted_index.non-expressers | 78 |
| abstract_inverted_index.IL7R-expression | 149, 216 |
| abstract_inverted_index.IL7Rp-addiction | 151 |
| abstract_inverted_index.IL7Rp-mutation) | 84 |
| abstract_inverted_index.IL7Rp-mutations | 70 |
| abstract_inverted_index.JAK-inhibition, | 226 |
| abstract_inverted_index.non-expressers, | 102 |
| abstract_inverted_index.primary-derived | 114 |
| abstract_inverted_index.(IL7R-expression | 82 |
| abstract_inverted_index.epigenetic-level | 100 |
| abstract_inverted_index.IL7R-deregulation | 92 |
| abstract_inverted_index.(IL7Rp-mutations). | 87 |
| abstract_inverted_index.leukemia-supportive | 35 |
| abstract_inverted_index.targeted-therapies. | 23 |
| abstract_inverted_index.post-transcriptional | 107 |
| abstract_inverted_index.refractory/relapsing | 16 |
| abstract_inverted_index.refractory/relapsed-T-ALL. | 198 |
| abstract_inverted_index.IL7R-expression/IL7Rp-mutation), | 80 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 19 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98440434 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |