MGMT-Methylated Alleles Are Distributed Heterogeneously Within Glioma Samples Irrespective ofIDHStatus and Chromosome 10q Deletion Article Swipe
Laura Fontana
,
Silvia Tabano
,
Eleonora Bonaparte
,
Giovanni Marfia
,
Chiara Pesenti
,
Rossella Falcone
,
Claudia Augello
,
Nicole Carlessi
,
Rosamaria Silipigni
,
Silvana Guerneri
,
Rolando Campanella
,
Manuela Caroli
,
Silvia Maria Sirchia
,
Silvano Bòsari
,
Monica Miozzo
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1093/jnen/nlw052
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1093/jnen/nlw052
Several molecular markers drive diagnostic classification, prognostic stratification, and/or prediction of response to therapy in patients with gliomas. Among them, IDH gene mutations are valuable markers for defining subtypes and are strongly associated with epigenetic silencing of the methylguanine DNA methyltransferase (MGMT) gene. However, little is known about the percentage of MGMT-methylated alleles in IDH-mutated cells or the potential association between MGMT methylation and deletion of chromosome 10q, which encompasses the MGMT locus. Here, we quantitatively assessed MGMT methylation and IDH1 mutation in 208 primary glioma samples to explore possible differences associated with the IDH genotype. We also explored a potential association between MGMT methylation and loss of chromosome 10q. We observed that MGMT methylation was heterogeneously distributed within glioma samples irrespective of IDH status suggesting an incomplete overlap between IDH1-mutated and MGMT-methylated alleles and indicating a partial association between these two events. Moreover, loss of one MGMT allele did not affect the methylation level of the remaining allele. MGMT was methylated in about half of gliomas harboring a 10q deletion; in those cases, loss of heterozygosity might be considered a second hit leading to complete inactivation of MGMT and further contributing to tumor progression.
Related Topics
Concepts
Biology
Methyltransferase
Allele
Loss of heterozygosity
Glioma
Methylation
IDH1
Epigenetics
Genetics
Locus (genetics)
DNA methylation
Cancer research
O-6-methylguanine-DNA methyltransferase
Genotype
Gene
Mutation
Gene expression
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jnen/nlw052
- https://academic.oup.com/jnen/article-pdf/75/8/791/10816741/nlw052.pdf
- OA Status
- bronze
- Cited By
- 22
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2460290517
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2460290517Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/jnen/nlw052Digital Object Identifier
- Title
-
MGMT-Methylated Alleles Are Distributed Heterogeneously Within Glioma Samples Irrespective ofIDHStatus and Chromosome 10q DeletionWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
-
2016-06-26Full publication date if available
- Authors
-
Laura Fontana, Silvia Tabano, Eleonora Bonaparte, Giovanni Marfia, Chiara Pesenti, Rossella Falcone, Claudia Augello, Nicole Carlessi, Rosamaria Silipigni, Silvana Guerneri, Rolando Campanella, Manuela Caroli, Silvia Maria Sirchia, Silvano Bòsari, Monica MiozzoList of authors in order
- Landing page
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https://doi.org/10.1093/jnen/nlw052Publisher landing page
- PDF URL
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https://academic.oup.com/jnen/article-pdf/75/8/791/10816741/nlw052.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/jnen/article-pdf/75/8/791/10816741/nlw052.pdfDirect OA link when available
- Concepts
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Biology, Methyltransferase, Allele, Loss of heterozygosity, Glioma, Methylation, IDH1, Epigenetics, Genetics, Locus (genetics), DNA methylation, Cancer research, O-6-methylguanine-DNA methyltransferase, Genotype, Gene, Mutation, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 2, 2022: 7, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 112 |
| abstract_inverted_index.with | 16, 33, 92 |
| abstract_inverted_index.Among | 18 |
| abstract_inverted_index.Here, | 73 |
| abstract_inverted_index.about | 47, 163 |
| abstract_inverted_index.cells | 55 |
| abstract_inverted_index.drive | 3 |
| abstract_inverted_index.gene. | 42 |
| abstract_inverted_index.known | 46 |
| abstract_inverted_index.level | 154 |
| abstract_inverted_index.might | 177 |
| abstract_inverted_index.them, | 19 |
| abstract_inverted_index.these | 140 |
| abstract_inverted_index.those | 172 |
| abstract_inverted_index.tumor | 193 |
| abstract_inverted_index.which | 68 |
| abstract_inverted_index.(MGMT) | 41 |
| abstract_inverted_index.affect | 151 |
| abstract_inverted_index.allele | 148 |
| abstract_inverted_index.and/or | 8 |
| abstract_inverted_index.cases, | 173 |
| abstract_inverted_index.glioma | 85, 119 |
| abstract_inverted_index.little | 44 |
| abstract_inverted_index.locus. | 72 |
| abstract_inverted_index.second | 181 |
| abstract_inverted_index.status | 124 |
| abstract_inverted_index.within | 118 |
| abstract_inverted_index.Several | 0 |
| abstract_inverted_index.allele. | 158 |
| abstract_inverted_index.alleles | 52, 133 |
| abstract_inverted_index.between | 60, 102, 129, 139 |
| abstract_inverted_index.events. | 142 |
| abstract_inverted_index.explore | 88 |
| abstract_inverted_index.further | 190 |
| abstract_inverted_index.gliomas | 166 |
| abstract_inverted_index.leading | 183 |
| abstract_inverted_index.markers | 2, 25 |
| abstract_inverted_index.overlap | 128 |
| abstract_inverted_index.partial | 137 |
| abstract_inverted_index.primary | 84 |
| abstract_inverted_index.samples | 86, 120 |
| abstract_inverted_index.therapy | 13 |
| abstract_inverted_index.However, | 43 |
| abstract_inverted_index.assessed | 76 |
| abstract_inverted_index.complete | 185 |
| abstract_inverted_index.defining | 27 |
| abstract_inverted_index.deletion | 64 |
| abstract_inverted_index.explored | 98 |
| abstract_inverted_index.gliomas. | 17 |
| abstract_inverted_index.mutation | 81 |
| abstract_inverted_index.observed | 111 |
| abstract_inverted_index.patients | 15 |
| abstract_inverted_index.possible | 89 |
| abstract_inverted_index.response | 11 |
| abstract_inverted_index.strongly | 31 |
| abstract_inverted_index.subtypes | 28 |
| abstract_inverted_index.valuable | 24 |
| abstract_inverted_index.Moreover, | 143 |
| abstract_inverted_index.deletion; | 170 |
| abstract_inverted_index.genotype. | 95 |
| abstract_inverted_index.harboring | 167 |
| abstract_inverted_index.molecular | 1 |
| abstract_inverted_index.mutations | 22 |
| abstract_inverted_index.potential | 58, 100 |
| abstract_inverted_index.remaining | 157 |
| abstract_inverted_index.silencing | 35 |
| abstract_inverted_index.associated | 32, 91 |
| abstract_inverted_index.chromosome | 66, 108 |
| abstract_inverted_index.considered | 179 |
| abstract_inverted_index.diagnostic | 4 |
| abstract_inverted_index.epigenetic | 34 |
| abstract_inverted_index.incomplete | 127 |
| abstract_inverted_index.indicating | 135 |
| abstract_inverted_index.methylated | 161 |
| abstract_inverted_index.percentage | 49 |
| abstract_inverted_index.prediction | 9 |
| abstract_inverted_index.prognostic | 6 |
| abstract_inverted_index.suggesting | 125 |
| abstract_inverted_index.IDH-mutated | 54 |
| abstract_inverted_index.association | 59, 101, 138 |
| abstract_inverted_index.differences | 90 |
| abstract_inverted_index.distributed | 117 |
| abstract_inverted_index.encompasses | 69 |
| abstract_inverted_index.methylation | 62, 78, 104, 114, 153 |
| abstract_inverted_index.IDH1-mutated | 130 |
| abstract_inverted_index.contributing | 191 |
| abstract_inverted_index.inactivation | 186 |
| abstract_inverted_index.irrespective | 121 |
| abstract_inverted_index.progression. | 194 |
| abstract_inverted_index.methylguanine | 38 |
| abstract_inverted_index.heterozygosity | 176 |
| abstract_inverted_index.quantitatively | 75 |
| abstract_inverted_index.MGMT-methylated | 51, 132 |
| abstract_inverted_index.classification, | 5 |
| abstract_inverted_index.heterogeneously | 116 |
| abstract_inverted_index.stratification, | 7 |
| abstract_inverted_index.methyltransferase | 40 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.749139 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |