Mikania micrantha silver nanoparticles exhibit anticancer activities against human lung adenocarcinoma via caspase-mediated apoptotic cell death Article Swipe
Fanai Lalsangpuii
,
Samuel Lalthazuala Rokhum
,
F. Nghakliana
,
Joseph V.L. Ruatpuia
,
Lalchhandami Tochhawng
,
Amit Kumar Trivedi
,
R. Lalfakzuala
,
Zothan Siama
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/21691401.2024.2325942
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/21691401.2024.2325942
Green-mediated synthesis of nanoparticles has earned a promising role in the area of nanotechnology due to their biomedical applications. This study describes the synthesis of silver nanoparticles (AgNPs) using Mikania micrantha leaf extract and its functional activities against cancer. The synthesis of AgNPs was confirmed using Ultraviolet-Visible (UV-Vis) spectrum that exhibited an absorption band at 459 nm. The bioactive compounds of M. micrantha leaf extract that functioned as reducing and capping agents were confirmed by a shift in the absorption bands in Fourier Transform Infra-red Spectroscopy (FT-IR). Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) studies validated the spherical shape and size of AgNPs, respectively. Energy Dispersive Spectroscopy (EDS) analysis revealed the presence of elemental silver. The crystalline nature of AgNPs was confirmed by the X-ray Diffraction Analysis (XRD). AgNPs effectively induced cytotoxicity and prevented A549 cell colony formation in a dose-dependent manner. Treatment of A549 cells with AgNPs also increased DNA damage, which was coupled with elevated lipid peroxidation and decreased antioxidant enzymes such as glutathione (GSH), glutathione-s-transferase (GST), and superoxide dismutase (SOD). Following AgNPs treatment, the mRNA expression levels of the pro-apoptotic genes as well as the activities of caspases were significantly elevated in A549 cells while the expression levels of anti-apoptotic genes were downregulated. Our study demonstrates the potential of the synthesised AgNPs for cancer therapy possibly targeting the apoptotic pathway.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/21691401.2024.2325942
- https://www.tandfonline.com/doi/pdf/10.1080/21691401.2024.2325942?needAccess=true
- OA Status
- gold
- Cited By
- 15
- References
- 39
- Related Works
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- OpenAlex ID
- https://openalex.org/W4392645232
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392645232Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/21691401.2024.2325942Digital Object Identifier
- Title
-
Mikania micrantha silver nanoparticles exhibit anticancer activities against human lung adenocarcinoma via caspase-mediated apoptotic cell deathWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-11Full publication date if available
- Authors
-
Fanai Lalsangpuii, Samuel Lalthazuala Rokhum, F. Nghakliana, Joseph V.L. Ruatpuia, Lalchhandami Tochhawng, Amit Kumar Trivedi, R. Lalfakzuala, Zothan SiamaList of authors in order
- Landing page
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https://doi.org/10.1080/21691401.2024.2325942Publisher landing page
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https://www.tandfonline.com/doi/pdf/10.1080/21691401.2024.2325942?needAccess=trueDirect link to full text PDF
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-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/21691401.2024.2325942?needAccess=trueDirect OA link when available
- Concepts
-
Silver nanoparticle, Chemistry, Apoptosis, Cytotoxicity, Glutathione, Superoxide dismutase, Nuclear chemistry, A549 cell, Lipid peroxidation, Biophysics, Biochemistry, Antioxidant, Nanoparticle, Nanotechnology, Materials science, Enzyme, Biology, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 12, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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