Immune cell metabolism in cancer drug resistance: Advances in target discovery and clinical translation Article Swipe
Liangjie Sun
,
Zhao Guo
,
Shuhang Wang
,
Ning Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21147/j.issn.1000-9604.2025.03.11
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21147/j.issn.1000-9604.2025.03.11
Drug resistance continues to be the principal limiting factor in achieving a cure for patients with cancer, significantly hindering the long-term efficacy of novel cancer drugs. Accumulating evidence has shown that metabolites derived from tumor cells regulate immune cell metabolism via tumor microenvironment crosstalk. However, as immunometabolic research has deepened, the leading role played by the intrinsic metabolic regulation of immune cells in the drug resistance of tumor cells has been discovered. Immune metabolites have been shown to cause immune resistance, target therapy resistance, and chemotherapy resistance, and drugs that target immune metabolism have great potential. To date, researchers have not fully explored the impact of immune-derived metabolites on tumor cells and their influence on the responsiveness to cancer drugs. In this review, we focus on the lactate, fatty acid, glucose, and nucleotide metabolic alterations that take place in T cells and macrophages and how these changes can impair anti-tumor immunity, ultimately promoting tumor cell survival and decreasing responsiveness to the corresponding therapeutic approaches. We present the current developments in drugs targeting immunometabolic pathways and propose constructive suggestions, such as precise delivery to immune cell targets to enhance efficacy and safety, offering novel perspectives for cancer drug development.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.21147/j.issn.1000-9604.2025.03.11
- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.21147/j.issn.1000-9604.2025.03.11Digital Object Identifier
- Title
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Immune cell metabolism in cancer drug resistance: Advances in target discovery and clinical translationWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Liangjie Sun, Zhao Guo, Shuhang Wang, Ning LiList of authors in order
- Landing page
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https://doi.org/10.21147/j.issn.1000-9604.2025.03.11Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.21147/j.issn.1000-9604.2025.03.11Direct OA link when available
- Concepts
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Immune system, Drug discovery, Translation (biology), Drug resistance, Cell metabolism, Drug, Medicine, Drug metabolism, Computational biology, Pharmacology, Bioinformatics, Cancer research, Biology, Metabolism, Immunology, Internal medicine, Genetics, Gene, Messenger RNATop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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