Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma Article Swipe
Darci J. Phillips
,
Magdalena Matusiak
,
Belén Rivero‐Gutiérrez
,
Salil S. Bhate
,
Graham L. Barlow
,
Sizun Jiang
,
János Demeter
,
Kimberly S. Smythe
,
Robert H. Pierce
,
Steven P. Fling
,
Nirasha Ramchurren
,
Martin A. Cheever
,
Yury Goltsev
,
Robert B. West
,
Michael S. Khodadoust
,
Youn H. Kim
,
Christian M. Schürch
,
Garry P. Nolan
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.12.06.20244913
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.12.06.20244913
Anti-PD-1 immunotherapies have transformed cancer treatment, yet the determinants of clinical response are largely unknown. We performed CODEX multiplexed tissue imaging and RNA sequencing on 70 tumor regions from 14 advanced cutaneous T cell lymphoma (CTCL) patients enrolled in a clinical trial of pembrolizumab therapy. Clinical response was not associated with the frequency of tumor-infiltrating T cell subsets, but rather with striking differences in the spatial organization and functional immune state of the tumor microenvironment (TME). After treatment, pembrolizumab responders had a localized enrichment of tumor and CD4 + T cells, which coincided with immune activation and cytotoxic PD-1 + CD4 + T cells. In contrast, non-responders had a localized enrichment of Tregs pre- and post-treatment, consistent with a persistently immunosuppressed TME and exhausted PD-1 + CD4 + T cells. Integrating these findings by computing the physical distances between PD-1 + CD4 + T cells, tumor cells, and Tregs revealed a spatial biomarker predictive of pembrolizumab response. Finally, the chemokine CXCL13 was upregulated in tumor cells in responders post-treatment, suggesting that chemoattraction of PD-1 + CD4 + T cells towards tumor cells facilitates a positive outcome. Together, these data show that T cell topography reflects the balance of effector and suppressive activity within the TME and predicts clinical response to PD-1 blockade in CTCL.
Related Topics
Concepts
Tumor microenvironment
Pembrolizumab
Immune system
Cytotoxic T cell
Immune checkpoint
T cell
Immunotherapy
Medicine
Cancer research
Immunology
Chemokine
Biology
In vitro
Biochemistry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.12.06.20244913
- https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdf
- OA Status
- green
- Cited By
- 19
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3110842356
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3110842356Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2020.12.06.20244913Digital Object Identifier
- Title
-
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphomaWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-08Full publication date if available
- Authors
-
Darci J. Phillips, Magdalena Matusiak, Belén Rivero‐Gutiérrez, Salil S. Bhate, Graham L. Barlow, Sizun Jiang, János Demeter, Kimberly S. Smythe, Robert H. Pierce, Steven P. Fling, Nirasha Ramchurren, Martin A. Cheever, Yury Goltsev, Robert B. West, Michael S. Khodadoust, Youn H. Kim, Christian M. Schürch, Garry P. NolanList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.12.06.20244913Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdfDirect OA link when available
- Concepts
-
Tumor microenvironment, Pembrolizumab, Immune system, Cytotoxic T cell, Immune checkpoint, T cell, Immunotherapy, Medicine, Cancer research, Immunology, Chemokine, Biology, In vitro, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 5, 2023: 8, 2022: 2, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
95Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3110842356 |
|---|---|
| doi | https://doi.org/10.1101/2020.12.06.20244913 |
| ids.doi | https://doi.org/10.1101/2020.12.06.20244913 |
| ids.mag | 3110842356 |
| ids.openalex | https://openalex.org/W3110842356 |
| fwci | 2.70888804 |
| type | preprint |
| title | Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11811 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2708 |
| topics[0].subfield.display_name | Dermatology |
| topics[0].display_name | Cutaneous lymphoproliferative disorders research |
| topics[1].id | https://openalex.org/T10185 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9940000176429749 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Lymphoma Diagnosis and Treatment |
| topics[2].id | https://openalex.org/T10158 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9933000206947327 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Cancer Immunotherapy and Biomarkers |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776107976 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7435160875320435 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1786433 |
| concepts[0].display_name | Tumor microenvironment |
| concepts[1].id | https://openalex.org/C2780057760 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7173194289207458 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q13896859 |
| concepts[1].display_name | Pembrolizumab |
| concepts[2].id | https://openalex.org/C8891405 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6525664329528809 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[2].display_name | Immune system |
| concepts[3].id | https://openalex.org/C154317977 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5872691869735718 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q376266 |
| concepts[3].display_name | Cytotoxic T cell |
| concepts[4].id | https://openalex.org/C2780851360 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5134721398353577 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q21686041 |
| concepts[4].display_name | Immune checkpoint |
| concepts[5].id | https://openalex.org/C2776090121 |
| concepts[5].level | 3 |
| concepts[5].score | 0.49965929985046387 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q193529 |
| concepts[5].display_name | T cell |
| concepts[6].id | https://openalex.org/C2777701055 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4761638343334198 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[6].display_name | Immunotherapy |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.459126353263855 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C502942594 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4580809473991394 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[8].display_name | Cancer research |
| concepts[9].id | https://openalex.org/C203014093 |
| concepts[9].level | 1 |
| concepts[9].score | 0.430038183927536 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[9].display_name | Immunology |
| concepts[10].id | https://openalex.org/C13373296 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4260016083717346 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q421866 |
| concepts[10].display_name | Chemokine |
| concepts[11].id | https://openalex.org/C86803240 |
| concepts[11].level | 0 |
| concepts[11].score | 0.3345658779144287 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[11].display_name | Biology |
| concepts[12].id | https://openalex.org/C202751555 |
| concepts[12].level | 2 |
| concepts[12].score | 0.06484192609786987 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[12].display_name | In vitro |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/tumor-microenvironment |
| keywords[0].score | 0.7435160875320435 |
| keywords[0].display_name | Tumor microenvironment |
| keywords[1].id | https://openalex.org/keywords/pembrolizumab |
| keywords[1].score | 0.7173194289207458 |
| keywords[1].display_name | Pembrolizumab |
| keywords[2].id | https://openalex.org/keywords/immune-system |
| keywords[2].score | 0.6525664329528809 |
| keywords[2].display_name | Immune system |
| keywords[3].id | https://openalex.org/keywords/cytotoxic-t-cell |
| keywords[3].score | 0.5872691869735718 |
| keywords[3].display_name | Cytotoxic T cell |
| keywords[4].id | https://openalex.org/keywords/immune-checkpoint |
| keywords[4].score | 0.5134721398353577 |
| keywords[4].display_name | Immune checkpoint |
| keywords[5].id | https://openalex.org/keywords/t-cell |
| keywords[5].score | 0.49965929985046387 |
| keywords[5].display_name | T cell |
| keywords[6].id | https://openalex.org/keywords/immunotherapy |
| keywords[6].score | 0.4761638343334198 |
| keywords[6].display_name | Immunotherapy |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.459126353263855 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/cancer-research |
| keywords[8].score | 0.4580809473991394 |
| keywords[8].display_name | Cancer research |
| keywords[9].id | https://openalex.org/keywords/immunology |
| keywords[9].score | 0.430038183927536 |
| keywords[9].display_name | Immunology |
| keywords[10].id | https://openalex.org/keywords/chemokine |
| keywords[10].score | 0.4260016083717346 |
| keywords[10].display_name | Chemokine |
| keywords[11].id | https://openalex.org/keywords/biology |
| keywords[11].score | 0.3345658779144287 |
| keywords[11].display_name | Biology |
| keywords[12].id | https://openalex.org/keywords/in-vitro |
| keywords[12].score | 0.06484192609786987 |
| keywords[12].display_name | In vitro |
| language | en |
| locations[0].id | doi:10.1101/2020.12.06.20244913 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2020.12.06.20244913 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5016969499 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-0804-3342 |
| authorships[0].author.display_name | Darci J. Phillips |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I97018004 |
| authorships[0].affiliations[2].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[0].institutions[0].id | https://openalex.org/I97018004 |
| authorships[0].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Stanford University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Darci Phillips |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[1].author.id | https://openalex.org/A5009009669 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-8201-1621 |
| authorships[1].author.display_name | Magdalena Matusiak |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[1].institutions[0].id | https://openalex.org/I97018004 |
| authorships[1].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Stanford University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Magdalena Matusiak |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[2].author.id | https://openalex.org/A5027229242 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1263-0873 |
| authorships[2].author.display_name | Belén Rivero‐Gutiérrez |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[2].institutions[0].id | https://openalex.org/I97018004 |
| authorships[2].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Stanford University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Belén Rivero Gutierrez |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[3].author.id | https://openalex.org/A5010448622 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2057-9182 |
| authorships[3].author.display_name | Salil S. Bhate |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I97018004 |
| authorships[3].affiliations[2].raw_affiliation_string | Department of Bioengineering, Stanford University Schools of Engineering and Medicine, Stanford, CA 9305, USA |
| authorships[3].institutions[0].id | https://openalex.org/I97018004 |
| authorships[3].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Stanford University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Salil S. Bhate |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Bioengineering, Stanford University Schools of Engineering and Medicine, Stanford, CA 9305, USA, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[4].author.id | https://openalex.org/A5043770327 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-9335-5414 |
| authorships[4].author.display_name | Graham L. Barlow |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[4].institutions[0].id | https://openalex.org/I97018004 |
| authorships[4].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Stanford University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Graham L. Barlow |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[5].author.id | https://openalex.org/A5026021659 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6149-3142 |
| authorships[5].author.display_name | Sizun Jiang |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[5].institutions[0].id | https://openalex.org/I97018004 |
| authorships[5].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Stanford University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Sizun Jiang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[6].author.id | https://openalex.org/A5018153402 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7301-8055 |
| authorships[6].author.display_name | János Demeter |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[6].institutions[0].id | https://openalex.org/I97018004 |
| authorships[6].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Stanford University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Janos Demeter |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[7].author.id | https://openalex.org/A5017330947 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2329-8298 |
| authorships[7].author.display_name | Kimberly S. Smythe |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210089486 |
| authorships[7].affiliations[0].raw_affiliation_string | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[7].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[7].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Kimberly S. Smythe |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[8].author.id | https://openalex.org/A5083390361 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-2677-144X |
| authorships[8].author.display_name | Robert H. Pierce |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210089486 |
| authorships[8].affiliations[0].raw_affiliation_string | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[8].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[8].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Robert H. Pierce |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[9].author.id | https://openalex.org/A5023766816 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6263-0153 |
| authorships[9].author.display_name | Steven P. Fling |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210089486 |
| authorships[9].affiliations[0].raw_affiliation_string | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[9].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[9].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[9].institutions[0].type | nonprofit |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Steven P. Fling |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[10].author.id | https://openalex.org/A5017244881 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-6613-9342 |
| authorships[10].author.display_name | Nirasha Ramchurren |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210089486 |
| authorships[10].affiliations[0].raw_affiliation_string | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[10].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[10].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[10].institutions[0].type | nonprofit |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Nirasha Ramchurren |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[11].author.id | https://openalex.org/A5007551071 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-6892-4141 |
| authorships[11].author.display_name | Martin A. Cheever |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210089486 |
| authorships[11].affiliations[0].raw_affiliation_string | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[11].institutions[0].id | https://openalex.org/I4210089486 |
| authorships[11].institutions[0].ror | https://ror.org/007ps6h72 |
| authorships[11].institutions[0].type | nonprofit |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210089486 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Fred Hutch Cancer Center |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Martin A. Cheever |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| authorships[12].author.id | https://openalex.org/A5040981016 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-4079-7969 |
| authorships[12].author.display_name | Yury Goltsev |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[12].affiliations[1].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[12].institutions[0].id | https://openalex.org/I97018004 |
| authorships[12].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Stanford University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Yury Goltsev |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[13].author.id | https://openalex.org/A5044981994 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-8330-8283 |
| authorships[13].author.display_name | Robert B. West |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[13].institutions[0].id | https://openalex.org/I97018004 |
| authorships[13].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Stanford University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Robert B. West |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[14].author.id | https://openalex.org/A5057879662 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-9061-7351 |
| authorships[14].author.display_name | Michael S. Khodadoust |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[14].affiliations[0].raw_affiliation_string | Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[14].institutions[0].id | https://openalex.org/I97018004 |
| authorships[14].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Stanford University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Michael S. Khodadoust |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[15].author.id | https://openalex.org/A5103275168 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-2686-5873 |
| authorships[15].author.display_name | Youn H. Kim |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[15].affiliations[1].raw_affiliation_string | Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[15].institutions[0].id | https://openalex.org/I97018004 |
| authorships[15].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | Stanford University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Youn H. Kim |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[16].author.id | https://openalex.org/A5019984620 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-1792-1768 |
| authorships[16].author.display_name | Christian M. Schürch |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[16].affiliations[1].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[16].institutions[0].id | https://openalex.org/I97018004 |
| authorships[16].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | Stanford University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Christian M. Schürch |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[17].author.id | https://openalex.org/A5033995613 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-8862-9043 |
| authorships[17].author.display_name | Garry P. Nolan |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I97018004 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I97018004 |
| authorships[17].affiliations[1].raw_affiliation_string | Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| authorships[17].institutions[0].id | https://openalex.org/I97018004 |
| authorships[17].institutions[0].ror | https://ror.org/00f54p054 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I97018004 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | Stanford University |
| authorships[17].author_position | last |
| authorships[17].raw_author_name | Garry P. Nolan |
| authorships[17].is_corresponding | True |
| authorships[17].raw_affiliation_strings | Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA, Department of Pathology, Stanford University School of Medicine, Stanford, CA 9405, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11811 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2708 |
| primary_topic.subfield.display_name | Dermatology |
| primary_topic.display_name | Cutaneous lymphoproliferative disorders research |
| related_works | https://openalex.org/W2585407512, https://openalex.org/W3037068108, https://openalex.org/W2059423835, https://openalex.org/W2945780494, https://openalex.org/W4200022043, https://openalex.org/W2112727616, https://openalex.org/W2884525857, https://openalex.org/W4322720888, https://openalex.org/W4296613612, https://openalex.org/W3193904228 |
| cited_by_count | 19 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 5 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 2 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 3 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2020.12.06.20244913 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2020.12.06.20244913 |
| primary_location.id | doi:10.1101/2020.12.06.20244913 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2020/12/08/2020.12.06.20244913.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2020.12.06.20244913 |
| publication_date | 2020-12-08 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2909964376, https://openalex.org/W1877715550, https://openalex.org/W1980482034, https://openalex.org/W2096322385, https://openalex.org/W2791483720, https://openalex.org/W2794577178, https://openalex.org/W2761586559, https://openalex.org/W2043115278, https://openalex.org/W2202793491, https://openalex.org/W2412725897, https://openalex.org/W1973788479, https://openalex.org/W2807826791, https://openalex.org/W2974710297, https://openalex.org/W2769936894, https://openalex.org/W2938362298, https://openalex.org/W2254907138, https://openalex.org/W2883806089, https://openalex.org/W2999681746, https://openalex.org/W3047081808, https://openalex.org/W2949238013, https://openalex.org/W2973165200, https://openalex.org/W2942610007, https://openalex.org/W2096850086, https://openalex.org/W2110957729, https://openalex.org/W2799977252, https://openalex.org/W2743162492, https://openalex.org/W2013561306, https://openalex.org/W2023797125, https://openalex.org/W2011392586, https://openalex.org/W1986553267, https://openalex.org/W2625424984, https://openalex.org/W2514407904, https://openalex.org/W2050784416, https://openalex.org/W2125810837, https://openalex.org/W2142300779, https://openalex.org/W2914335731, https://openalex.org/W2039123767, https://openalex.org/W2801309958, https://openalex.org/W2655262992, https://openalex.org/W2785803176, https://openalex.org/W2076669505, https://openalex.org/W2164992400, https://openalex.org/W2530790566, https://openalex.org/W1734655579, https://openalex.org/W2018236996, https://openalex.org/W2130621814, https://openalex.org/W2135905952, https://openalex.org/W2574194867, https://openalex.org/W3032968363, https://openalex.org/W2021922201, https://openalex.org/W2101208734, https://openalex.org/W2001017617, https://openalex.org/W2077255595, https://openalex.org/W3082188955, https://openalex.org/W2012628829, https://openalex.org/W2116576993, https://openalex.org/W2959190003, https://openalex.org/W2940972161, https://openalex.org/W2091961397, https://openalex.org/W2961686530, https://openalex.org/W2894997912, https://openalex.org/W2753945613, https://openalex.org/W2112727616, https://openalex.org/W2617691667, https://openalex.org/W4313384025, https://openalex.org/W2609921003, https://openalex.org/W2164842455, https://openalex.org/W2620775812, https://openalex.org/W1966107523, https://openalex.org/W2887655773, https://openalex.org/W2807534769, https://openalex.org/W3036281565, https://openalex.org/W2766123339, https://openalex.org/W2897351155, https://openalex.org/W2894584497, https://openalex.org/W2894796660, https://openalex.org/W3015035400, https://openalex.org/W2911752971, https://openalex.org/W2798160602, https://openalex.org/W2987436342, https://openalex.org/W2885239461, https://openalex.org/W2622106120, https://openalex.org/W2896342720, https://openalex.org/W2928276758, https://openalex.org/W2788915030, https://openalex.org/W2358421111, https://openalex.org/W2039716761, https://openalex.org/W1951724000, https://openalex.org/W2774486220, https://openalex.org/W2949177718, https://openalex.org/W2131681506, https://openalex.org/W2786672974, https://openalex.org/W4254687493, https://openalex.org/W3099768174, https://openalex.org/W1587026990 |
| referenced_works_count | 95 |
| abstract_inverted_index.+ | 88, 99, 101, 125, 127, 140, 142, 174, 176 |
| abstract_inverted_index.T | 32, 55, 89, 102, 128, 143, 177, 191 |
| abstract_inverted_index.a | 39, 81, 108, 118, 150, 183 |
| abstract_inverted_index.14 | 29 |
| abstract_inverted_index.70 | 25 |
| abstract_inverted_index.In | 104 |
| abstract_inverted_index.We | 15 |
| abstract_inverted_index.by | 133 |
| abstract_inverted_index.in | 38, 63, 163, 166, 212 |
| abstract_inverted_index.of | 9, 42, 53, 71, 84, 111, 154, 172, 197 |
| abstract_inverted_index.on | 24 |
| abstract_inverted_index.to | 209 |
| abstract_inverted_index.CD4 | 87, 100, 126, 141, 175 |
| abstract_inverted_index.RNA | 22 |
| abstract_inverted_index.TME | 121, 204 |
| abstract_inverted_index.and | 21, 67, 86, 96, 114, 122, 147, 199, 205 |
| abstract_inverted_index.are | 12 |
| abstract_inverted_index.but | 58 |
| abstract_inverted_index.had | 80, 107 |
| abstract_inverted_index.not | 48 |
| abstract_inverted_index.the | 7, 51, 64, 72, 135, 158, 195, 203 |
| abstract_inverted_index.was | 47, 161 |
| abstract_inverted_index.yet | 6 |
| abstract_inverted_index.PD-1 | 98, 124, 139, 173, 210 |
| abstract_inverted_index.cell | 33, 56, 192 |
| abstract_inverted_index.data | 188 |
| abstract_inverted_index.from | 28 |
| abstract_inverted_index.have | 2 |
| abstract_inverted_index.pre- | 113 |
| abstract_inverted_index.show | 189 |
| abstract_inverted_index.that | 170, 190 |
| abstract_inverted_index.with | 50, 60, 93, 117 |
| abstract_inverted_index.After | 76 |
| abstract_inverted_index.CODEX | 17 |
| abstract_inverted_index.CTCL. | 213 |
| abstract_inverted_index.Tregs | 112, 148 |
| abstract_inverted_index.cells | 165, 178, 181 |
| abstract_inverted_index.state | 70 |
| abstract_inverted_index.these | 131, 187 |
| abstract_inverted_index.trial | 41 |
| abstract_inverted_index.tumor | 26, 73, 85, 145, 164, 180 |
| abstract_inverted_index.which | 91 |
| abstract_inverted_index.(CTCL) | 35 |
| abstract_inverted_index.(TME). | 75 |
| abstract_inverted_index.CXCL13 | 160 |
| abstract_inverted_index.cancer | 4 |
| abstract_inverted_index.cells, | 90, 144, 146 |
| abstract_inverted_index.cells. | 103, 129 |
| abstract_inverted_index.immune | 69, 94 |
| abstract_inverted_index.rather | 59 |
| abstract_inverted_index.tissue | 19 |
| abstract_inverted_index.within | 202 |
| abstract_inverted_index.balance | 196 |
| abstract_inverted_index.between | 138 |
| abstract_inverted_index.imaging | 20 |
| abstract_inverted_index.largely | 13 |
| abstract_inverted_index.regions | 27 |
| abstract_inverted_index.spatial | 65, 151 |
| abstract_inverted_index.towards | 179 |
| abstract_inverted_index.Clinical | 45 |
| abstract_inverted_index.Finally, | 157 |
| abstract_inverted_index.activity | 201 |
| abstract_inverted_index.advanced | 30 |
| abstract_inverted_index.blockade | 211 |
| abstract_inverted_index.clinical | 10, 40, 207 |
| abstract_inverted_index.effector | 198 |
| abstract_inverted_index.enrolled | 37 |
| abstract_inverted_index.findings | 132 |
| abstract_inverted_index.lymphoma | 34 |
| abstract_inverted_index.outcome. | 185 |
| abstract_inverted_index.patients | 36 |
| abstract_inverted_index.physical | 136 |
| abstract_inverted_index.positive | 184 |
| abstract_inverted_index.predicts | 206 |
| abstract_inverted_index.reflects | 194 |
| abstract_inverted_index.response | 11, 46, 208 |
| abstract_inverted_index.revealed | 149 |
| abstract_inverted_index.striking | 61 |
| abstract_inverted_index.subsets, | 57 |
| abstract_inverted_index.therapy. | 44 |
| abstract_inverted_index.unknown. | 14 |
| abstract_inverted_index.Anti-PD-1 | 0 |
| abstract_inverted_index.Together, | 186 |
| abstract_inverted_index.biomarker | 152 |
| abstract_inverted_index.chemokine | 159 |
| abstract_inverted_index.coincided | 92 |
| abstract_inverted_index.computing | 134 |
| abstract_inverted_index.contrast, | 105 |
| abstract_inverted_index.cutaneous | 31 |
| abstract_inverted_index.cytotoxic | 97 |
| abstract_inverted_index.distances | 137 |
| abstract_inverted_index.exhausted | 123 |
| abstract_inverted_index.frequency | 52 |
| abstract_inverted_index.localized | 82, 109 |
| abstract_inverted_index.performed | 16 |
| abstract_inverted_index.response. | 156 |
| abstract_inverted_index.activation | 95 |
| abstract_inverted_index.associated | 49 |
| abstract_inverted_index.consistent | 116 |
| abstract_inverted_index.enrichment | 83, 110 |
| abstract_inverted_index.functional | 68 |
| abstract_inverted_index.predictive | 153 |
| abstract_inverted_index.responders | 79, 167 |
| abstract_inverted_index.sequencing | 23 |
| abstract_inverted_index.suggesting | 169 |
| abstract_inverted_index.topography | 193 |
| abstract_inverted_index.treatment, | 5, 77 |
| abstract_inverted_index.Integrating | 130 |
| abstract_inverted_index.differences | 62 |
| abstract_inverted_index.facilitates | 182 |
| abstract_inverted_index.multiplexed | 18 |
| abstract_inverted_index.suppressive | 200 |
| abstract_inverted_index.transformed | 3 |
| abstract_inverted_index.upregulated | 162 |
| abstract_inverted_index.determinants | 8 |
| abstract_inverted_index.organization | 66 |
| abstract_inverted_index.persistently | 119 |
| abstract_inverted_index.pembrolizumab | 43, 78, 155 |
| abstract_inverted_index.non-responders | 106 |
| abstract_inverted_index.chemoattraction | 171 |
| abstract_inverted_index.immunotherapies | 1 |
| abstract_inverted_index.post-treatment, | 115, 168 |
| abstract_inverted_index.immunosuppressed | 120 |
| abstract_inverted_index.microenvironment | 74 |
| abstract_inverted_index.tumor-infiltrating | 54 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5033995613, https://openalex.org/A5019984620 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I97018004 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.88254342 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |