Immune Checkpoint Inhibitor Therapy and Acute Coronary Syndrome: A Review of Mechanisms and Management Article Swipe
Rachel S Saganty
,
Orly Leiva
,
Elizabeth Hutchins
,
Ashley Stein-Merlob
,
Eric H. Yang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.125.042824
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.125.042824
Immune checkpoint inhibitor (ICI) therapy is a class of immune‐activating therapies that has revolutionized the treatment of various cancers over the past decade. With expanding clinical indications of this drug class, understanding the short‐term and long‐term implications of checkpoint inhibitor therapy has grown in importance. Numerous reports have highlighted potential inflammatory adverse effects, including cardiotoxicity. Efforts to characterize cardiovascular adverse events, however, have largely focused on myocarditis with emerging evidence demonstrating the association between ICI therapies and atherosclerotic cardiovascular disease. Given the inherently higher risk of thrombosis and bleeding in patients with cancer, the safe and effective management of ICI‐associated acute coronary syndrome remains a therapeutic challenge requiring a tailored and multidisciplinary approach. In this review, we discuss the pathophysiology of ICI‐associated atherosclerosis, the complexities of acute coronary syndrome management in patients with cancer, and the opportunities for risk prevention in patients receiving ICI therapies.
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Metadata
- Type
- article
- Language
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- Landing Page
- https://doi.org/10.1161/jaha.125.042824
- OA Status
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- 1
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- 89
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All OpenAlex metadata
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Immune Checkpoint Inhibitor Therapy and Acute Coronary Syndrome: A Review of Mechanisms and ManagementWork title
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enPrimary language
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2025Year of publication
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2025-11-26Full publication date if available
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Rachel S Saganty, Orly Leiva, Elizabeth Hutchins, Ashley Stein-Merlob, Eric H. YangList of authors in order
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https://doi.org/10.1161/jaha.125.042824Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1161/jaha.125.042824Direct OA link when available
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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89Number of works referenced by this work
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| abstract_inverted_index.long‐term | 35 |
| abstract_inverted_index.myocarditis | 66 |
| abstract_inverted_index.therapeutic | 105 |
| abstract_inverted_index.characterize | 57 |
| abstract_inverted_index.complexities | 124 |
| abstract_inverted_index.implications | 36 |
| abstract_inverted_index.inflammatory | 50 |
| abstract_inverted_index.short‐term | 33 |
| abstract_inverted_index.demonstrating | 70 |
| abstract_inverted_index.opportunities | 136 |
| abstract_inverted_index.understanding | 31 |
| abstract_inverted_index.cardiovascular | 58, 78 |
| abstract_inverted_index.revolutionized | 13 |
| abstract_inverted_index.atherosclerotic | 77 |
| abstract_inverted_index.cardiotoxicity. | 54 |
| abstract_inverted_index.pathophysiology | 119 |
| abstract_inverted_index.ICI‐associated | 99, 121 |
| abstract_inverted_index.atherosclerosis, | 122 |
| abstract_inverted_index.multidisciplinary | 111 |
| abstract_inverted_index.immune‐activating | 9 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5075120074 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I161318765, https://openalex.org/I2801272649 |
| citation_normalized_percentile |