Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models Article Swipe
Carla Usai
,
Erola Ainsua‐Enrich
,
Víctor Urrea
,
Edwards Pradenas
,
Cristina Lorca-Oró
,
Ferran Tarrés-Freixas
,
Núria Roca
,
Mónica Pérez
,
Carlos Ávila‐Nieto
,
Maria Luisa Rodrı́guez de la Concepción
,
Núria Pedreño-López
,
Julieta Carabelli
,
Benjamin Trinité
,
Ester Ballana
,
Eva Riveira‐Muñoz
,
Nuria Izquierdo‐Useros
,
Bonaventura Clotet
,
Julià Blanco
,
Vı́ctor Guallar
,
Guillermo Cantero
,
Júlia Vergara‐Alert
,
Jorge Carrillo
,
Joaquím Segalés
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41541-024-00840-0
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41541-024-00840-0
Age is associated with reduced efficacy of vaccines and linked to higher risk of severe COVID-19. Here we determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike glycoprotein (S-29) that had previously shown high efficacy in young animals. Thirteen to 18-month-old golden Syrian hamsters (GSH) and 22–23-month-old K18-hCAE2 mice were immunised twice with S-29 protein in AddaVax TM adjuvant. GSH were intranasally inoculated with SARS-CoV-2 either two weeks or four months after the booster dose, while all K18-hACE2 mice were intranasally inoculated two weeks after the second immunisation. Body weight and clinical signs were recorded daily post-inoculation. Lesions and viral load were investigated in different target tissues. Immunisation induced seroconversion and production of neutralising antibodies; however, animals were only partially protected from weight loss. We observed a significant reduction in the amount of viral RNA and a faster viral protein clearance in the tissues of immunized animals. Infectious particles showed a faster decay in vaccinated animals while tissue lesion development was not altered. In GSH, the shortest interval between immunisation and inoculation reduced RNA levels in the lungs, while the longest interval was equally effective in reducing RNA in nasal turbinates; viral nucleoprotein amount decreased in both tissues. In mice, immunisation was able to improve the survival of infected animals. Despite the high protection shown in young animals, S-29 efficacy was reduced in the geriatric population. Our research highlights the importance of testing vaccine efficacy in older animals as part of preclinical vaccine evaluation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41541-024-00840-0
- https://www.nature.com/articles/s41541-024-00840-0.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392188132
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392188132Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41541-024-00840-0Digital Object Identifier
- Title
-
Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal modelsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-27Full publication date if available
- Authors
-
Carla Usai, Erola Ainsua‐Enrich, Víctor Urrea, Edwards Pradenas, Cristina Lorca-Oró, Ferran Tarrés-Freixas, Núria Roca, Mónica Pérez, Carlos Ávila‐Nieto, Maria Luisa Rodrı́guez de la Concepción, Núria Pedreño-López, Julieta Carabelli, Benjamin Trinité, Ester Ballana, Eva Riveira‐Muñoz, Nuria Izquierdo‐Useros, Bonaventura Clotet, Julià Blanco, Vı́ctor Guallar, Guillermo Cantero, Júlia Vergara‐Alert, Jorge Carrillo, Joaquím SegalésList of authors in order
- Landing page
-
https://doi.org/10.1038/s41541-024-00840-0Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41541-024-00840-0.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41541-024-00840-0.pdfDirect OA link when available
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Seroconversion, Virology, Viral load, Medicine, Nasal administration, Antibody, Inoculation, Population, Biology, Immunology, Virus, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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