Immunity at the Crossroads of Cellular Metabolism: Navigating T helper Shifts in the Periparturient Period of Dairy Cows 3694 Article Swipe
Trinidad Fernández Wallace
,
Usman Arshad
,
Malena Cid de la Paz
,
Martina Mancheno
,
Grace Praisler
,
Tanya France
,
Heather White
,
Lautaro Rostoll Cangiano
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/jimmun/vkaf283.1465
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/jimmun/vkaf283.1465
Description The transition from pregnancy to lactation in dairy cows brings major metabolic and physiological shifts, which lead to an increase in their disease susceptibility and immune dysfunction. The contribution of T helper (CD4+) cells to this altered state during the periparturient period remains poorly understood. This study aimed to evaluate the metabolic and proliferation capacity changes of CD4+ T cells during the periparturient period of dairy cows. Blood samples from multiparous Holstein cows (n = 18) were collected at -28, +3, and +28 days relative to calving. Peripheral blood mononuclear cells were isolated and CD4+ T cells were obtained using magnetic sorting. Cell metabolic function was measured with a Seahorse XF HS mini analyzer in resting and PMA/Ionomycin-activated cells. For proliferation capacity, cells were incubated with Concanavalin A for 72h and tracked using Cell Trace in Flow Cytometry. Data was analyzed in SAS 9.4 using a linear mixed-effect model with repeated measures. Results showed higher rates of glycolysis in CD4+ T cells during the post-partum period (P < 0.01) as well as oxidative phosphorylation capacity (P < 0.05). The proliferation capacity of the cells according to their expansion and division index, was higher at d + 3 than d -28 (P < 0.05). This suggests that CD4+ T cells metabolism as well as their proliferation capacity are affected by the physiological changes that occur after calving, which may impact immune response effectiveness. Funding Sources Dairy Innovation Hub. Topic Categories Veterinary and Comparative Immunology (VET)
Related Topics
Concepts
Immune system
Concanavalin A
Biology
Peripheral blood mononuclear cell
Immunity
Lactation
Immunology
Period (music)
T cell
Andrology
Dairy cattle
Internal medicine
Endocrinology
Cellular immunity
Pregnancy
Flow cytometry
Oxidative phosphorylation
Cell growth
Colostrum
Metabolism
Humoral immunity
Carbohydrate metabolism
Medicine
Postpartum period
Blood sugar
Physiology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jimmun/vkaf283.1465
- https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1465/65411821/vkaf283.1465.pdf
- OA Status
- bronze
- OpenAlex ID
- https://openalex.org/W7106324768
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106324768Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/jimmun/vkaf283.1465Digital Object Identifier
- Title
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Immunity at the Crossroads of Cellular Metabolism: Navigating T helper Shifts in the Periparturient Period of Dairy Cows 3694Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-01Full publication date if available
- Authors
-
Trinidad Fernández Wallace, Usman Arshad, Malena Cid de la Paz, Martina Mancheno, Grace Praisler, Tanya France, Heather White, Lautaro Rostoll CangianoList of authors in order
- Landing page
-
https://doi.org/10.1093/jimmun/vkaf283.1465Publisher landing page
- PDF URL
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https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1465/65411821/vkaf283.1465.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1465/65411821/vkaf283.1465.pdfDirect OA link when available
- Concepts
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Immune system, Concanavalin A, Biology, Peripheral blood mononuclear cell, Immunity, Lactation, Immunology, Period (music), T cell, Andrology, Dairy cattle, Internal medicine, Endocrinology, Cellular immunity, Pregnancy, Flow cytometry, Oxidative phosphorylation, Cell growth, Colostrum, Metabolism, Humoral immunity, Carbohydrate metabolism, Medicine, Postpartum period, Blood sugar, PhysiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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