Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in Cambodia Article Swipe
Camila D. Odio
,
Christina Yek
,
Chloe M. Hasund
,
Somnang Man
,
Piseth Ly
,
Sreynik Nhek
,
Sophana Chea
,
Chanthap Lon
,
Charlie Voirin
,
Rekol Huy
,
Rithea Leang
,
Chea Huch
,
Elaine W. Lamirande
,
Stephen S. Whitehead
,
L Fabiano Oliveira
,
Jessica E. Manning
,
Leah C. Katzelnick
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiae422
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiae422
Background Seroprevalence studies are the standard for disease surveillance, and serology determined eligibility for the first dengue vaccine. Expanding flavivirus co-circulation and vaccination complicate testing. We evaluate the accuracy of a common dengue virus serological assay, examine immunity to non-dengue flaviviruses as a contributor to decreased performance, and assess whether alternative cut points may improve assay performance. Methods Children (n = 770) aged 2–9 years in Kampong Speu, Cambodia were enrolled in a prospective longitudinal study, and PanBio indirect dengue virus immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) was performed. Plaque reduction neutralization tests (PRNTs) using dengue viruses were performed on a subset to assess the accuracy of the IgG ELISA, and PRNTs with Zika, Japanese encephalitis, and West Nile viruses evaluated immunity to non-dengue flaviviruses. Receiver operating curve analysis identified an alternative cut point to improve IgG ELISA accuracy. Results The dengue IgG ELISA had a lower specificity than previously reported (58% vs 93%–100%). Of those with false-positive IgG results, 46% had detectable neutralizing antibodies against other flaviviruses including 14% against West Nile virus. A higher IgG cut point improved the test accuracy in this population. Conclusions Physicians and public health authorities should be alert for West Nile in Cambodia. Immunity to non-dengue flaviviruses can impact dengue surveillance. Clinical Trials Registration NCT03534245.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/infdis/jiae422
- OA Status
- hybrid
- References
- 27
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402643165Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/infdis/jiae422Digital Object Identifier
- Title
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Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in CambodiaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-19Full publication date if available
- Authors
-
Camila D. Odio, Christina Yek, Chloe M. Hasund, Somnang Man, Piseth Ly, Sreynik Nhek, Sophana Chea, Chanthap Lon, Charlie Voirin, Rekol Huy, Rithea Leang, Chea Huch, Elaine W. Lamirande, Stephen S. Whitehead, L Fabiano Oliveira, Jessica E. Manning, Leah C. KatzelnickList of authors in order
- Landing page
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https://doi.org/10.1093/infdis/jiae422Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1093/infdis/jiae422Direct OA link when available
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Dengue fever, Dengue virus, Virology, Antibody, Flavivirus, Immunoglobulin M, Immunoglobulin G, Immunity, Biology, Virus, Immunology, Immune systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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