Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics Article Swipe
Samantha Álvarez-Herrera
,
Raúl Escamilla
,
Óscar Medina‐Contreras
,
Ricardo Saracco
,
Yvonne Flores-Medina
,
Gabriela Hurtado‐Alvarado
,
José Luis Maldonado-García
,
Enrique Becerril‐Villanueva
,
Gilberto Pérez‐Sánchez
,
Lenin Pavón
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2020.00195
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2020.00195
Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2020.00195
- OA Status
- gold
- Cited By
- 43
- References
- 376
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3018209011
All OpenAlex metadata
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https://openalex.org/W3018209011Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fendo.2020.00195Digital Object Identifier
- Title
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Immunoendocrine Peripheral Effects Induced by Atypical AntipsychoticsWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-04-21Full publication date if available
- Authors
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Samantha Álvarez-Herrera, Raúl Escamilla, Óscar Medina‐Contreras, Ricardo Saracco, Yvonne Flores-Medina, Gabriela Hurtado‐Alvarado, José Luis Maldonado-García, Enrique Becerril‐Villanueva, Gilberto Pérez‐Sánchez, Lenin PavónList of authors in order
- Landing page
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https://doi.org/10.3389/fendo.2020.00195Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fendo.2020.00195Direct OA link when available
- Concepts
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Medicine, Peripheral, Schizophrenia (object-oriented programming), Bioinformatics, Pediatrics, Internal medicine, Psychiatry, BiologyTop concepts (fields/topics) attached by OpenAlex
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43Total citation count in OpenAlex
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2025: 10, 2024: 11, 2023: 10, 2022: 6, 2021: 4Per-year citation counts (last 5 years)
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376Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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