Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma Article Swipe
Jagtar Singh
,
Thanuja Thachil
,
Mathew Suji Eapen
,
Aijye Lim
,
Wajiha Sufyan
,
Robert V. Rawson
,
H. J. Duncan
,
Paolo De Ieso
,
Sukhwinder Singh Sohal
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/mco.2021.2353
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/mco.2021.2353
Cytokines influence the biological behaviour of prostate cancer (PC) and may influence patient outcome and serve as useful prognostic biomarkers. The aim of the present study was to evaluate cytokine expression levels in prostatic needle biopsy specimens and the association with clinicopathological characteristics of patients with PC. A total of 18 patients with PC who underwent transrectal ultrasound (TRUS) guided prostate biopsy were included in the clinical study. These patients were naïve to radiotherapy (RT) or androgen deprivation therapy prior to TRUS biopsy and clinical follow up data was collected. Cytokine expression levels were analysed by using immunohistochemistry and Spearman's correlation test was used to determine the correlation between cytokine expression and clinicopathological characteristics. Expression levels of pro-inflammatory TNF-α and IL-6 decreased as Gleason score (GS) increased; however, a statistically significant difference was not detected. A statically significant correlation was observed between needle biopsy specimen and pre-RT plasma sample expression levels of pro-inflammatory TNF-α and IL-6 (P=0.01 and P=0.05, respectively) and anti-inflammatory TGF-β1 (P=0.05). However, further studies are needed to confirm these results using a larger sample size to confirm the prognostic value of pro-inflammatory TNF-α and IL-6 and anti-inflammatory TGF-β1 in patients with PC.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/mco.2021.2353
- https://www.spandidos-publications.com/10.3892/mco.2021.2353/download
- OA Status
- diamond
- Cited By
- 5
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3185769336
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3185769336Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/mco.2021.2353Digital Object Identifier
- Title
-
Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-16Full publication date if available
- Authors
-
Jagtar Singh, Thanuja Thachil, Mathew Suji Eapen, Aijye Lim, Wajiha Sufyan, Robert V. Rawson, H. J. Duncan, Paolo De Ieso, Sukhwinder Singh SohalList of authors in order
- Landing page
-
https://doi.org/10.3892/mco.2021.2353Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/mco.2021.2353/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/mco.2021.2353/downloadDirect OA link when available
- Concepts
-
Medicine, Prostate, Prostate cancer, Biopsy, Immunohistochemistry, Cytokine, Adenocarcinoma, Ultrasound, Urology, Pathology, Cancer, Internal medicine, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3185769336 |
|---|---|
| doi | https://doi.org/10.3892/mco.2021.2353 |
| ids.doi | https://doi.org/10.3892/mco.2021.2353 |
| ids.mag | 3185769336 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34405051 |
| ids.openalex | https://openalex.org/W3185769336 |
| fwci | 0.88436621 |
| type | article |
| title | Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma |
| biblio.issue | 3 |
| biblio.volume | 15 |
| biblio.last_page | 191 |
| biblio.first_page | 191 |
| topics[0].id | https://openalex.org/T10124 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Prostate Cancer Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T10543 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9980000257492065 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Prostate Cancer Treatment and Research |
| topics[2].id | https://openalex.org/T12866 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.993399977684021 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2745 |
| topics[2].subfield.display_name | Rheumatology |
| topics[2].display_name | Urologic and reproductive health conditions |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8142571449279785 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2776235491 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6912448406219482 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q9625 |
| concepts[1].display_name | Prostate |
| concepts[2].id | https://openalex.org/C2780192828 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6407519578933716 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q181257 |
| concepts[2].display_name | Prostate cancer |
| concepts[3].id | https://openalex.org/C2775934546 |
| concepts[3].level | 2 |
| concepts[3].score | 0.637188196182251 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q179991 |
| concepts[3].display_name | Biopsy |
| concepts[4].id | https://openalex.org/C204232928 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6261672377586365 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q899285 |
| concepts[4].display_name | Immunohistochemistry |
| concepts[5].id | https://openalex.org/C2778690821 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5679836273193359 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q212354 |
| concepts[5].display_name | Cytokine |
| concepts[6].id | https://openalex.org/C2781182431 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5052431225776672 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q356033 |
| concepts[6].display_name | Adenocarcinoma |
| concepts[7].id | https://openalex.org/C143753070 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4545014798641205 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162564 |
| concepts[7].display_name | Ultrasound |
| concepts[8].id | https://openalex.org/C126894567 |
| concepts[8].level | 1 |
| concepts[8].score | 0.43827587366104126 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q105650 |
| concepts[8].display_name | Urology |
| concepts[9].id | https://openalex.org/C142724271 |
| concepts[9].level | 1 |
| concepts[9].score | 0.43521106243133545 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[9].display_name | Pathology |
| concepts[10].id | https://openalex.org/C121608353 |
| concepts[10].level | 2 |
| concepts[10].score | 0.42383432388305664 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[10].display_name | Cancer |
| concepts[11].id | https://openalex.org/C126322002 |
| concepts[11].level | 1 |
| concepts[11].score | 0.4070820212364197 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[11].display_name | Internal medicine |
| concepts[12].id | https://openalex.org/C126838900 |
| concepts[12].level | 1 |
| concepts[12].score | 0.21944090723991394 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q77604 |
| concepts[12].display_name | Radiology |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8142571449279785 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/prostate |
| keywords[1].score | 0.6912448406219482 |
| keywords[1].display_name | Prostate |
| keywords[2].id | https://openalex.org/keywords/prostate-cancer |
| keywords[2].score | 0.6407519578933716 |
| keywords[2].display_name | Prostate cancer |
| keywords[3].id | https://openalex.org/keywords/biopsy |
| keywords[3].score | 0.637188196182251 |
| keywords[3].display_name | Biopsy |
| keywords[4].id | https://openalex.org/keywords/immunohistochemistry |
| keywords[4].score | 0.6261672377586365 |
| keywords[4].display_name | Immunohistochemistry |
| keywords[5].id | https://openalex.org/keywords/cytokine |
| keywords[5].score | 0.5679836273193359 |
| keywords[5].display_name | Cytokine |
| keywords[6].id | https://openalex.org/keywords/adenocarcinoma |
| keywords[6].score | 0.5052431225776672 |
| keywords[6].display_name | Adenocarcinoma |
| keywords[7].id | https://openalex.org/keywords/ultrasound |
| keywords[7].score | 0.4545014798641205 |
| keywords[7].display_name | Ultrasound |
| keywords[8].id | https://openalex.org/keywords/urology |
| keywords[8].score | 0.43827587366104126 |
| keywords[8].display_name | Urology |
| keywords[9].id | https://openalex.org/keywords/pathology |
| keywords[9].score | 0.43521106243133545 |
| keywords[9].display_name | Pathology |
| keywords[10].id | https://openalex.org/keywords/cancer |
| keywords[10].score | 0.42383432388305664 |
| keywords[10].display_name | Cancer |
| keywords[11].id | https://openalex.org/keywords/internal-medicine |
| keywords[11].score | 0.4070820212364197 |
| keywords[11].display_name | Internal medicine |
| keywords[12].id | https://openalex.org/keywords/radiology |
| keywords[12].score | 0.21944090723991394 |
| keywords[12].display_name | Radiology |
| language | en |
| locations[0].id | doi:10.3892/mco.2021.2353 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2754683124 |
| locations[0].source.issn | 2049-9450, 2049-9469 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2049-9450 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Molecular and Clinical Oncology |
| locations[0].source.host_organization | https://openalex.org/P4310320412 |
| locations[0].source.host_organization_name | Spandidos Publishing |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320412 |
| locations[0].license | |
| locations[0].pdf_url | https://www.spandidos-publications.com/10.3892/mco.2021.2353/download |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Molecular and Clinical Oncology |
| locations[0].landing_page_url | https://doi.org/10.3892/mco.2021.2353 |
| locations[1].id | pmid:34405051 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Molecular and clinical oncology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34405051 |
| locations[2].id | pmh:oai:eprints.utas.edu.au:37492 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400075 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Open Access Repository (University of Tasmania) |
| locations[2].source.host_organization | https://openalex.org/I129801699 |
| locations[2].source.host_organization_name | University of Tasmania |
| locations[2].source.host_organization_lineage | https://openalex.org/I129801699 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | Article |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:8327082 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Mol Clin Oncol |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8327082 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5101930848 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-0457-2650 |
| authorships[0].author.display_name | Jagtar Singh |
| authorships[0].countries | AU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I29894533 |
| authorships[0].affiliations[0].raw_affiliation_string | College of Health and Human Sciences, Charles Darwin University, Northern Territory 0810, Australia |
| authorships[0].institutions[0].id | https://openalex.org/I29894533 |
| authorships[0].institutions[0].ror | https://ror.org/048zcaj52 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I29894533 |
| authorships[0].institutions[0].country_code | AU |
| authorships[0].institutions[0].display_name | Charles Darwin University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jagtar Singh |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | College of Health and Human Sciences, Charles Darwin University, Northern Territory 0810, Australia |
| authorships[1].author.id | https://openalex.org/A5077081586 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-0345-3924 |
| authorships[1].author.display_name | Thanuja Thachil |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210107908 |
| authorships[1].affiliations[0].raw_affiliation_string | Ballarat Austin Radiation Oncology Centre, Victoria 3350, Australia |
| authorships[1].institutions[0].id | https://openalex.org/I4210107908 |
| authorships[1].institutions[0].ror | https://ror.org/01jmjwt28 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210107908 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | Ballarat Health Services |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Thanuja Thachil |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Ballarat Austin Radiation Oncology Centre, Victoria 3350, Australia |
| authorships[2].author.id | https://openalex.org/A5037499701 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0570-7059 |
| authorships[2].author.display_name | Mathew Suji Eapen |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I129801699 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia |
| authorships[2].institutions[0].id | https://openalex.org/I129801699 |
| authorships[2].institutions[0].ror | https://ror.org/01nfmeh72 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I129801699 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | University of Tasmania |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mathew Eapen |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia |
| authorships[3].author.id | https://openalex.org/A5036044754 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Aijye Lim |
| authorships[3].countries | AU |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210137971 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[3].institutions[0].id | https://openalex.org/I4210137971 |
| authorships[3].institutions[0].ror | https://ror.org/04jq72f57 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210137971 |
| authorships[3].institutions[0].country_code | AU |
| authorships[3].institutions[0].display_name | Royal Darwin Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Aijye Lim |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[4].author.id | https://openalex.org/A5048424928 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Wajiha Sufyan |
| authorships[4].countries | AU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210137971 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[4].institutions[0].id | https://openalex.org/I4210137971 |
| authorships[4].institutions[0].ror | https://ror.org/04jq72f57 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210137971 |
| authorships[4].institutions[0].country_code | AU |
| authorships[4].institutions[0].display_name | Royal Darwin Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Wajiha Sufyan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[5].author.id | https://openalex.org/A5040174286 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0655-4963 |
| authorships[5].author.display_name | Robert V. Rawson |
| authorships[5].countries | AU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210137971 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[5].institutions[0].id | https://openalex.org/I4210137971 |
| authorships[5].institutions[0].ror | https://ror.org/04jq72f57 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210137971 |
| authorships[5].institutions[0].country_code | AU |
| authorships[5].institutions[0].display_name | Royal Darwin Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Robert Rawson |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Anatomical Pathology, Royal Darwin Hospital 0810, Australia |
| authorships[6].author.id | https://openalex.org/A5106183334 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | H. J. Duncan |
| authorships[6].countries | AU |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210137971 |
| authorships[6].affiliations[0].raw_affiliation_string | Urology Department, Darwin Private Hospital, Northern Territory 0810, Australia |
| authorships[6].institutions[0].id | https://openalex.org/I4210137971 |
| authorships[6].institutions[0].ror | https://ror.org/04jq72f57 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210137971 |
| authorships[6].institutions[0].country_code | AU |
| authorships[6].institutions[0].display_name | Royal Darwin Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Henry Duncan |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Urology Department, Darwin Private Hospital, Northern Territory 0810, Australia |
| authorships[7].author.id | https://openalex.org/A5010320850 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Paolo De Ieso |
| authorships[7].countries | AU |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2800555584 |
| authorships[7].affiliations[0].raw_affiliation_string | Peter MacCallum Cancer Centre, Victoria 3000, Australia |
| authorships[7].institutions[0].id | https://openalex.org/I2800555584 |
| authorships[7].institutions[0].ror | https://ror.org/02a8bt934 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2800555584 |
| authorships[7].institutions[0].country_code | AU |
| authorships[7].institutions[0].display_name | Peter MacCallum Cancer Centre |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Paolo De Ieso |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Peter MacCallum Cancer Centre, Victoria 3000, Australia |
| authorships[8].author.id | https://openalex.org/A5084474144 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9627-6498 |
| authorships[8].author.display_name | Sukhwinder Singh Sohal |
| authorships[8].countries | AU |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I129801699 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia |
| authorships[8].institutions[0].id | https://openalex.org/I129801699 |
| authorships[8].institutions[0].ror | https://ror.org/01nfmeh72 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I129801699 |
| authorships[8].institutions[0].country_code | AU |
| authorships[8].institutions[0].display_name | University of Tasmania |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Sukhwinder Sohal |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.spandidos-publications.com/10.3892/mco.2021.2353/download |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10124 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Prostate Cancer Diagnosis and Treatment |
| related_works | https://openalex.org/W299695548, https://openalex.org/W2351153092, https://openalex.org/W3171449477, https://openalex.org/W2384122898, https://openalex.org/W151774199, https://openalex.org/W2075763133, https://openalex.org/W2088520467, https://openalex.org/W2376423713, https://openalex.org/W1583600832, https://openalex.org/W2084723631 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3892/mco.2021.2353 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2754683124 |
| best_oa_location.source.issn | 2049-9450, 2049-9469 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2049-9450 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Molecular and Clinical Oncology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320412 |
| best_oa_location.source.host_organization_name | Spandidos Publishing |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320412 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.spandidos-publications.com/10.3892/mco.2021.2353/download |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Molecular and Clinical Oncology |
| best_oa_location.landing_page_url | https://doi.org/10.3892/mco.2021.2353 |
| primary_location.id | doi:10.3892/mco.2021.2353 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2754683124 |
| primary_location.source.issn | 2049-9450, 2049-9469 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2049-9450 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Molecular and Clinical Oncology |
| primary_location.source.host_organization | https://openalex.org/P4310320412 |
| primary_location.source.host_organization_name | Spandidos Publishing |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320412 |
| primary_location.license | |
| primary_location.pdf_url | https://www.spandidos-publications.com/10.3892/mco.2021.2353/download |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Molecular and Clinical Oncology |
| primary_location.landing_page_url | https://doi.org/10.3892/mco.2021.2353 |
| publication_date | 2021-07-16 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2989313910, https://openalex.org/W2117792530, https://openalex.org/W2413635030, https://openalex.org/W1457801245, https://openalex.org/W1946846784, https://openalex.org/W2138037117, https://openalex.org/W1967347847, https://openalex.org/W1965831940, https://openalex.org/W2047496202, https://openalex.org/W2107142702, https://openalex.org/W2057955197, https://openalex.org/W2151325774, https://openalex.org/W2121576466, https://openalex.org/W2083043726, https://openalex.org/W1987181470, https://openalex.org/W2011120797, https://openalex.org/W2783358782, https://openalex.org/W1978761040, https://openalex.org/W1867393493, https://openalex.org/W2083291992, https://openalex.org/W2791592177, https://openalex.org/W2226492593, https://openalex.org/W1980505460, https://openalex.org/W1994320122, https://openalex.org/W2027279302, https://openalex.org/W1982261123, https://openalex.org/W2085807927, https://openalex.org/W2745706068, https://openalex.org/W2002384741, https://openalex.org/W1933727961, https://openalex.org/W2105863720, https://openalex.org/W2097839889, https://openalex.org/W1998118468, https://openalex.org/W2148416479, https://openalex.org/W1967712326, https://openalex.org/W2123857513, https://openalex.org/W1977353424, https://openalex.org/W1971556961, https://openalex.org/W3029005741, https://openalex.org/W2146777557 |
| referenced_works_count | 40 |
| abstract_inverted_index.A | 47, 135 |
| abstract_inverted_index.a | 128, 174 |
| abstract_inverted_index.18 | 50 |
| abstract_inverted_index.PC | 53 |
| abstract_inverted_index.as | 16, 122 |
| abstract_inverted_index.by | 95 |
| abstract_inverted_index.in | 32, 64, 191 |
| abstract_inverted_index.of | 5, 22, 43, 49, 116, 151, 183 |
| abstract_inverted_index.or | 75 |
| abstract_inverted_index.to | 27, 72, 80, 104, 169, 178 |
| abstract_inverted_index.up | 86 |
| abstract_inverted_index.PC. | 46, 194 |
| abstract_inverted_index.The | 20 |
| abstract_inverted_index.aim | 21 |
| abstract_inverted_index.and | 9, 14, 37, 83, 98, 111, 119, 145, 154, 157, 160, 186, 188 |
| abstract_inverted_index.are | 167 |
| abstract_inverted_index.may | 10 |
| abstract_inverted_index.not | 133 |
| abstract_inverted_index.the | 2, 23, 38, 65, 106, 180 |
| abstract_inverted_index.was | 26, 88, 102, 132, 139 |
| abstract_inverted_index.who | 54 |
| abstract_inverted_index.(GS) | 125 |
| abstract_inverted_index.(PC) | 8 |
| abstract_inverted_index.(RT) | 74 |
| abstract_inverted_index.IL-6 | 120, 155, 187 |
| abstract_inverted_index.TRUS | 81 |
| abstract_inverted_index.data | 87 |
| abstract_inverted_index.size | 177 |
| abstract_inverted_index.test | 101 |
| abstract_inverted_index.used | 103 |
| abstract_inverted_index.were | 62, 70, 93 |
| abstract_inverted_index.with | 40, 45, 52, 193 |
| abstract_inverted_index.These | 68 |
| abstract_inverted_index.prior | 79 |
| abstract_inverted_index.score | 124 |
| abstract_inverted_index.serve | 15 |
| abstract_inverted_index.study | 25 |
| abstract_inverted_index.these | 171 |
| abstract_inverted_index.total | 48 |
| abstract_inverted_index.using | 96, 173 |
| abstract_inverted_index.value | 182 |
| abstract_inverted_index.(TRUS) | 58 |
| abstract_inverted_index.TNF-α | 118, 153, 185 |
| abstract_inverted_index.biopsy | 35, 61, 82, 143 |
| abstract_inverted_index.cancer | 7 |
| abstract_inverted_index.follow | 85 |
| abstract_inverted_index.guided | 59 |
| abstract_inverted_index.larger | 175 |
| abstract_inverted_index.levels | 31, 92, 115, 150 |
| abstract_inverted_index.naïve | 71 |
| abstract_inverted_index.needed | 168 |
| abstract_inverted_index.needle | 34, 142 |
| abstract_inverted_index.plasma | 147 |
| abstract_inverted_index.pre-RT | 146 |
| abstract_inverted_index.sample | 148, 176 |
| abstract_inverted_index.study. | 67 |
| abstract_inverted_index.useful | 17 |
| abstract_inverted_index.(P=0.01 | 156 |
| abstract_inverted_index.Gleason | 123 |
| abstract_inverted_index.P=0.05, | 158 |
| abstract_inverted_index.TGF-β1 | 162, 190 |
| abstract_inverted_index.between | 108, 141 |
| abstract_inverted_index.confirm | 170, 179 |
| abstract_inverted_index.further | 165 |
| abstract_inverted_index.outcome | 13 |
| abstract_inverted_index.patient | 12 |
| abstract_inverted_index.present | 24 |
| abstract_inverted_index.results | 172 |
| abstract_inverted_index.studies | 166 |
| abstract_inverted_index.therapy | 78 |
| abstract_inverted_index.Cytokine | 90 |
| abstract_inverted_index.However, | 164 |
| abstract_inverted_index.analysed | 94 |
| abstract_inverted_index.androgen | 76 |
| abstract_inverted_index.clinical | 66, 84 |
| abstract_inverted_index.cytokine | 29, 109 |
| abstract_inverted_index.evaluate | 28 |
| abstract_inverted_index.however, | 127 |
| abstract_inverted_index.included | 63 |
| abstract_inverted_index.observed | 140 |
| abstract_inverted_index.patients | 44, 51, 69, 192 |
| abstract_inverted_index.prostate | 6, 60 |
| abstract_inverted_index.specimen | 144 |
| abstract_inverted_index.(P=0.05). | 163 |
| abstract_inverted_index.Cytokines | 0 |
| abstract_inverted_index.behaviour | 4 |
| abstract_inverted_index.decreased | 121 |
| abstract_inverted_index.detected. | 134 |
| abstract_inverted_index.determine | 105 |
| abstract_inverted_index.influence | 1, 11 |
| abstract_inverted_index.prostatic | 33 |
| abstract_inverted_index.specimens | 36 |
| abstract_inverted_index.underwent | 55 |
| abstract_inverted_index.Expression | 114 |
| abstract_inverted_index.Spearman's | 99 |
| abstract_inverted_index.biological | 3 |
| abstract_inverted_index.collected. | 89 |
| abstract_inverted_index.difference | 131 |
| abstract_inverted_index.expression | 30, 91, 110, 149 |
| abstract_inverted_index.increased; | 126 |
| abstract_inverted_index.prognostic | 18, 181 |
| abstract_inverted_index.statically | 136 |
| abstract_inverted_index.ultrasound | 57 |
| abstract_inverted_index.association | 39 |
| abstract_inverted_index.biomarkers. | 19 |
| abstract_inverted_index.correlation | 100, 107, 138 |
| abstract_inverted_index.deprivation | 77 |
| abstract_inverted_index.significant | 130, 137 |
| abstract_inverted_index.transrectal | 56 |
| abstract_inverted_index.radiotherapy | 73 |
| abstract_inverted_index.respectively) | 159 |
| abstract_inverted_index.statistically | 129 |
| abstract_inverted_index.characteristics | 42 |
| abstract_inverted_index.characteristics. | 113 |
| abstract_inverted_index.pro-inflammatory | 117, 152, 184 |
| abstract_inverted_index.anti-inflammatory | 161, 189 |
| abstract_inverted_index.clinicopathological | 41, 112 |
| abstract_inverted_index.immunohistochemistry | 97 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.72742609 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |