Immunometric and functional measurement of endogenous vasoinhibin in human sera Article Swipe
Magdalena Zamora
,
David M. Harris
,
Nils Davies
,
Johannes Ebnet
,
Peter Radermacher
,
Cosima Brucker
,
Christiane Waller
,
Juan Pablo Robles
,
Thomas Bertsch
,
Carmen Clapp
,
Jakob Triebel
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1345996
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1345996
Introduction Circulating levels of the antiangiogenic protein vasoinhibin, a fragment of prolactin, are of interest in vasoproliferative retinopathies, preeclampsia, and peripartum cardiomyopathy; however, it is difficult to determine the circulating levels of vasoinhibin due to the lack of quantitative assays. Methods This study used human serum samples to assess the concentration and bioactivity of vasoinhibin using a novel enzyme-linked immunosorbent assay (ELISA) for human vasoinhibin, which employs an anti-vasoinhibin monoclonal antibody, a human umbilical vein endothelial cell (HUVEC) proliferation assay, and a chick chorioallantoic membrane (CAM) angiogenesis assay. Results Serum samples from 17 pregnant women without (one group) and with preeclampsia and pregnancy induced hypertension (another group) demonstrated endogenous vasoinhibin concentrations in the range of 5–340 ng/ml. Immunoactive vasoinhibin levels were significantly higher in preeclampsia serum compared to healthy pregnancy serum (mean 63.09 ± 22.15 SD vs. 19.67 ± 13.34 ng/ml, p = 0.0003), as was the bioactive vasoinhibin level as determined by the HUVEC proliferation assay (56.12 ± 19.83 vs. 13.38 ± 4.88 ng/ml, p < 0.0001). There was a correlation between the concentration of vasoinhibin measured by ELISA and the HUVEC proliferation assay (Pearson r = 0.95, p < 0.0001). Healthy serum demonstrated a proangiogenic effect in the CAM assay (p < 0.05, compared to control), while serum from preeclamptic patients demonstrated an antiangiogenic effect (p < 0.05 vs. control), as did recombinant human vasoinhibin and a synthetic circular retro-inverse vasoinhibin analogue (CRIVi45-51). The antiangiogenic effects in the CAM assay and the inhibition of HUVEC proliferation were abolished by addition of the ELISA anti-vasoinhibin monoclonal antibody, but not by mouse IgG. Discussion These results demonstrate the first quantitation of endogenous vasoinhibin in human sera and the elevation of it levels and antiangiogenic activity in sera from women with preeclampsia. The development and implementation of a quantitative assay for vasoinhibin overcomes a long-standing barrier and suggests the thorough clinical verification of vasoinhibin as a relevant biomarker.
Related Topics
Concepts
Preeclampsia
Umbilical vein
Medicine
Endogeny
Endocrinology
Angiogenesis
Internal medicine
Monoclonal antibody
Andrology
Antibody
Human umbilical vein endothelial cell
Recombinant DNA
Pregnancy
Immunology
Chemistry
Biology
In vitro
Biochemistry
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2024.1345996
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1345996/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396224524
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396224524Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2024.1345996Digital Object Identifier
- Title
-
Immunometric and functional measurement of endogenous vasoinhibin in human seraWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-29Full publication date if available
- Authors
-
Magdalena Zamora, David M. Harris, Nils Davies, Johannes Ebnet, Peter Radermacher, Cosima Brucker, Christiane Waller, Juan Pablo Robles, Thomas Bertsch, Carmen Clapp, Jakob TriebelList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2024.1345996Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1345996/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1345996/pdfDirect OA link when available
- Concepts
-
Preeclampsia, Umbilical vein, Medicine, Endogeny, Endocrinology, Angiogenesis, Internal medicine, Monoclonal antibody, Andrology, Antibody, Human umbilical vein endothelial cell, Recombinant DNA, Pregnancy, Immunology, Chemistry, Biology, In vitro, Biochemistry, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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