Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study Article Swipe
Karen A. Autio
,
Christopher A. Klebanoff
,
David Schaer
,
John Kauh
,
Susan F. Slovin
,
Matthew Adamow
,
Victoria Blinder
,
Manisha Brahmachary
,
Michelle Carlsen
,
Elizabeth Comen
,
Daniel C. Danila
,
Thompson N. Doman
,
Jeremy C. Durack
,
Josef J. Fox
,
Jill S. Gluskin
,
David Hoffman
,
Suhyun Kang
,
Praneet Kang
,
Jonathan Landa
,
Philomena McAndrew
,
Shanu Modi
,
Michael J. Morris
,
Ruslan D. Novosiadly
,
Dana E. Rathkopf
,
Rachel Sanford
,
Sonya C. Chapman
,
Courtney M. Tate
,
Danni Yu
,
Phillip Wong
,
Heather L. McArthur
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.ccr-20-0855
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.ccr-20-0855
Purpose: Tumor-associated macrophages correlate with increased invasiveness, growth, and immunosuppression. Activation of the colony-stimulating factor-1 receptor (CSF-1R) results in proliferation, differentiation, and migration of monocytes/macrophages. This phase I study evaluated the immunologic and clinical activity, and safety profile of CSF-1R inhibition with the mAb LY3022855. Patients and Methods: Patients with advanced refractory metastatic breast cancer (MBC) or metastatic castration-resistant prostate cancer (mCRPC) were treated with LY3022855 intravenously in 6-week cycles in cohorts: (A) 1.25 mg/kg every 2 weeks (Q2W); (B) 1.0 mg/kg on weeks 1, 2, 4, and 5; (C) 100 mg once weekly; (D)100 mg Q2W. mCRPC patients were enrolled in cohorts A and B; patients with MBC were enrolled in all cohorts. Efficacy was assessed by RECIST and Prostate Cancer Clinical Trials Working Group 2 criteria. Results: Thirty-four patients (22 MBC; 12 mCRPC) received ≥1 dose of LY3022855. At day 8, circulating CSF-1 levels increased and proinflammatory monocytes CD14DIMCD16BRIGHT decreased. Best RECIST response was stable disease in five patients with MBC (23%; duration, 82–302 days) and three patients with mCRPC (25%; duration, 50–124 days). Two patients with MBC (cohort A) had durable stable disease >9 months and a third patient with MBC had palpable reduction in a nontarget neck mass. Immune-related gene activation in tumor biopsies posttreatment was observed. Common any grade treatment-related adverse events were fatigue, decreased appetite, nausea, asymptomatic increased lipase, and creatine phosphokinase. Conclusions: LY3022855 was well tolerated and showed evidence of immune modulation. Clinically meaningful stable disease >9 months was observed in two patients with MBC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1158/1078-0432.ccr-20-0855
- https://aacrjournals.org/clincancerres/article-pdf/26/21/5609/2064424/5609.pdf
- OA Status
- bronze
- Cited By
- 58
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3080640144
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3080640144Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1158/1078-0432.ccr-20-0855Digital Object Identifier
- Title
-
Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-26Full publication date if available
- Authors
-
Karen A. Autio, Christopher A. Klebanoff, David Schaer, John Kauh, Susan F. Slovin, Matthew Adamow, Victoria Blinder, Manisha Brahmachary, Michelle Carlsen, Elizabeth Comen, Daniel C. Danila, Thompson N. Doman, Jeremy C. Durack, Josef J. Fox, Jill S. Gluskin, David Hoffman, Suhyun Kang, Praneet Kang, Jonathan Landa, Philomena McAndrew, Shanu Modi, Michael J. Morris, Ruslan D. Novosiadly, Dana E. Rathkopf, Rachel Sanford, Sonya C. Chapman, Courtney M. Tate, Danni Yu, Phillip Wong, Heather L. McArthurList of authors in order
- Landing page
-
https://doi.org/10.1158/1078-0432.ccr-20-0855Publisher landing page
- PDF URL
-
https://aacrjournals.org/clincancerres/article-pdf/26/21/5609/2064424/5609.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://aacrjournals.org/clincancerres/article-pdf/26/21/5609/2064424/5609.pdfDirect OA link when available
- Concepts
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Prostate cancer, Refractory (planetary science), Medicine, Breast cancer, Prostate, Internal medicine, Oncology, Cancer, Cancer research, Biology, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
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58Total citation count in OpenAlex
- Citations by year (recent)
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2025: 12, 2024: 13, 2023: 7, 2022: 13, 2021: 12Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91673461 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |