Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias Article Swipe
Julian Swatler
,
Laura Turos-Korgul
,
Ewa Kozłowska
,
Katarzyna Piwocka
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13061203
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13061203
Both chronic myeloid leukemia and acute myeloid leukemia evade the immune response during their development and disease progression. As myeloid leukemia cells modify their bone marrow microenvironment, they lead to dysfunction of cytotoxic cells, such as CD8+ T cells or NK cells, simultaneously promoting development of immunosuppressive regulatory T cells and suppressive myeloid cells. This facilitates disease progression, spreading of leukemic blasts outside the bone marrow niche and therapy resistance. The following review focuses on main immunosuppressive features of myeloid leukemias. Firstly, factors derived directly from leukemic cells – inhibitory receptors, soluble factors and extracellular vesicles, are described. Further, we outline function, properties and origin of main immunosuppressive cells - regulatory T cells, myeloid derived suppressor cells and macrophages. Finally, we analyze interplay between recovery of effector immunity and therapeutic modalities, such as tyrosine kinase inhibitors and chemotherapy.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers13061203
- https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895
- OA Status
- gold
- Cited By
- 32
- References
- 232
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3135730237
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3135730237Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers13061203Digital Object Identifier
- Title
-
Immunosuppressive Cell Subsets and Factors in Myeloid LeukemiasWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-10Full publication date if available
- Authors
-
Julian Swatler, Laura Turos-Korgul, Ewa Kozłowska, Katarzyna PiwockaList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers13061203Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895Direct OA link when available
- Concepts
-
Myeloid leukemia, Myeloid, Bone marrow, Cancer research, Immunology, Cytotoxic T cell, Immune system, Leukemia, Haematopoiesis, CD8, Biology, Myeloid-derived Suppressor Cell, Medicine, Stem cell, Cell biology, Suppressor, Cancer, Internal medicine, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
32Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 14, 2024: 2, 2023: 5, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
232Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3135730237 |
|---|---|
| doi | https://doi.org/10.3390/cancers13061203 |
| ids.doi | https://doi.org/10.3390/cancers13061203 |
| ids.mag | 3135730237 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33801964 |
| ids.openalex | https://openalex.org/W3135730237 |
| fwci | 1.85798752 |
| type | review |
| title | Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias |
| awards[0].id | https://openalex.org/G4634462921 |
| awards[0].funder_id | https://openalex.org/F4320322511 |
| awards[0].display_name | |
| awards[0].funder_award_id | 2018/29/N/NZ3/01754 |
| awards[0].funder_display_name | Narodowe Centrum Nauki |
| awards[1].id | https://openalex.org/G4744163867 |
| awards[1].funder_id | https://openalex.org/F4320322511 |
| awards[1].display_name | |
| awards[1].funder_award_id | 2013/10/E/NZ3/00673 |
| awards[1].funder_display_name | Narodowe Centrum Nauki |
| biblio.issue | 6 |
| biblio.volume | 13 |
| biblio.last_page | 1203 |
| biblio.first_page | 1203 |
| topics[0].id | https://openalex.org/T11313 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | Immune cells in cancer |
| topics[1].id | https://openalex.org/T10309 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2720 |
| topics[1].subfield.display_name | Hematology |
| topics[1].display_name | Acute Myeloid Leukemia Research |
| topics[2].id | https://openalex.org/T11215 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9994000196456909 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Chronic Myeloid Leukemia Treatments |
| funders[0].id | https://openalex.org/F4320322511 |
| funders[0].ror | https://ror.org/03ha2q922 |
| funders[0].display_name | Narodowe Centrum Nauki |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C2778729363 |
| concepts[0].level | 2 |
| concepts[0].score | 0.692440927028656 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11688946 |
| concepts[0].display_name | Myeloid leukemia |
| concepts[1].id | https://openalex.org/C2779282312 |
| concepts[1].level | 2 |
| concepts[1].score | 0.59831702709198 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1956561 |
| concepts[1].display_name | Myeloid |
| concepts[2].id | https://openalex.org/C2780007613 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5641160607337952 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q546523 |
| concepts[2].display_name | Bone marrow |
| concepts[3].id | https://openalex.org/C502942594 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5513187050819397 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[3].display_name | Cancer research |
| concepts[4].id | https://openalex.org/C203014093 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5428587794303894 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[4].display_name | Immunology |
| concepts[5].id | https://openalex.org/C154317977 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5218673944473267 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q376266 |
| concepts[5].display_name | Cytotoxic T cell |
| concepts[6].id | https://openalex.org/C8891405 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4967944920063019 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[6].display_name | Immune system |
| concepts[7].id | https://openalex.org/C2778461978 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4717572331428528 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q29496 |
| concepts[7].display_name | Leukemia |
| concepts[8].id | https://openalex.org/C109159458 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4553963243961334 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q919283 |
| concepts[8].display_name | Haematopoiesis |
| concepts[9].id | https://openalex.org/C167672396 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4338863492012024 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q417800 |
| concepts[9].display_name | CD8 |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.41271668672561646 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C55721878 |
| concepts[11].level | 4 |
| concepts[11].score | 0.41150158643722534 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q15220362 |
| concepts[11].display_name | Myeloid-derived Suppressor Cell |
| concepts[12].id | https://openalex.org/C71924100 |
| concepts[12].level | 0 |
| concepts[12].score | 0.36950594186782837 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[12].display_name | Medicine |
| concepts[13].id | https://openalex.org/C28328180 |
| concepts[13].level | 2 |
| concepts[13].score | 0.2853264808654785 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[13].display_name | Stem cell |
| concepts[14].id | https://openalex.org/C95444343 |
| concepts[14].level | 1 |
| concepts[14].score | 0.17091059684753418 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[14].display_name | Cell biology |
| concepts[15].id | https://openalex.org/C179185449 |
| concepts[15].level | 3 |
| concepts[15].score | 0.11579492688179016 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q219699 |
| concepts[15].display_name | Suppressor |
| concepts[16].id | https://openalex.org/C121608353 |
| concepts[16].level | 2 |
| concepts[16].score | 0.08760726451873779 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[16].display_name | Cancer |
| concepts[17].id | https://openalex.org/C126322002 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0708446204662323 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[17].display_name | Internal medicine |
| concepts[18].id | https://openalex.org/C55493867 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[18].display_name | Biochemistry |
| concepts[19].id | https://openalex.org/C202751555 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[19].display_name | In vitro |
| keywords[0].id | https://openalex.org/keywords/myeloid-leukemia |
| keywords[0].score | 0.692440927028656 |
| keywords[0].display_name | Myeloid leukemia |
| keywords[1].id | https://openalex.org/keywords/myeloid |
| keywords[1].score | 0.59831702709198 |
| keywords[1].display_name | Myeloid |
| keywords[2].id | https://openalex.org/keywords/bone-marrow |
| keywords[2].score | 0.5641160607337952 |
| keywords[2].display_name | Bone marrow |
| keywords[3].id | https://openalex.org/keywords/cancer-research |
| keywords[3].score | 0.5513187050819397 |
| keywords[3].display_name | Cancer research |
| keywords[4].id | https://openalex.org/keywords/immunology |
| keywords[4].score | 0.5428587794303894 |
| keywords[4].display_name | Immunology |
| keywords[5].id | https://openalex.org/keywords/cytotoxic-t-cell |
| keywords[5].score | 0.5218673944473267 |
| keywords[5].display_name | Cytotoxic T cell |
| keywords[6].id | https://openalex.org/keywords/immune-system |
| keywords[6].score | 0.4967944920063019 |
| keywords[6].display_name | Immune system |
| keywords[7].id | https://openalex.org/keywords/leukemia |
| keywords[7].score | 0.4717572331428528 |
| keywords[7].display_name | Leukemia |
| keywords[8].id | https://openalex.org/keywords/haematopoiesis |
| keywords[8].score | 0.4553963243961334 |
| keywords[8].display_name | Haematopoiesis |
| keywords[9].id | https://openalex.org/keywords/cd8 |
| keywords[9].score | 0.4338863492012024 |
| keywords[9].display_name | CD8 |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.41271668672561646 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/myeloid-derived-suppressor-cell |
| keywords[11].score | 0.41150158643722534 |
| keywords[11].display_name | Myeloid-derived Suppressor Cell |
| keywords[12].id | https://openalex.org/keywords/medicine |
| keywords[12].score | 0.36950594186782837 |
| keywords[12].display_name | Medicine |
| keywords[13].id | https://openalex.org/keywords/stem-cell |
| keywords[13].score | 0.2853264808654785 |
| keywords[13].display_name | Stem cell |
| keywords[14].id | https://openalex.org/keywords/cell-biology |
| keywords[14].score | 0.17091059684753418 |
| keywords[14].display_name | Cell biology |
| keywords[15].id | https://openalex.org/keywords/suppressor |
| keywords[15].score | 0.11579492688179016 |
| keywords[15].display_name | Suppressor |
| keywords[16].id | https://openalex.org/keywords/cancer |
| keywords[16].score | 0.08760726451873779 |
| keywords[16].display_name | Cancer |
| keywords[17].id | https://openalex.org/keywords/internal-medicine |
| keywords[17].score | 0.0708446204662323 |
| keywords[17].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.3390/cancers13061203 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S168415115 |
| locations[0].source.issn | 2072-6694 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6694 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancers |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancers |
| locations[0].landing_page_url | https://doi.org/10.3390/cancers13061203 |
| locations[1].id | pmid:33801964 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancers |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33801964 |
| locations[2].id | pmh:oai:doaj.org/article:bc3f218ffa73468e9a3b2ce75afe4fc2 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cancers, Vol 13, Iss 1203, p 1203 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/bc3f218ffa73468e9a3b2ce75afe4fc2 |
| locations[3].id | pmh:oai:mdpi.com:/2072-6694/13/6/1203/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cancers; Volume 13; Issue 6; Pages: 1203 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/cancers13061203 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:7998753 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Cancers (Basel) |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7998753 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5053260357 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8710-2808 |
| authorships[0].author.display_name | Julian Swatler |
| authorships[0].countries | PL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I16778253 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| authorships[0].institutions[0].id | https://openalex.org/I16778253 |
| authorships[0].institutions[0].ror | https://ror.org/04waf7p94 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I16778253, https://openalex.org/I99542240 |
| authorships[0].institutions[0].country_code | PL |
| authorships[0].institutions[0].display_name | Instytut Biologii Doświadczalnej im. Marcelego Nenckiego |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Julian Swatler |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| authorships[1].author.id | https://openalex.org/A5071252656 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1732-3397 |
| authorships[1].author.display_name | Laura Turos-Korgul |
| authorships[1].countries | PL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I16778253 |
| authorships[1].affiliations[0].raw_affiliation_string | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| authorships[1].institutions[0].id | https://openalex.org/I16778253 |
| authorships[1].institutions[0].ror | https://ror.org/04waf7p94 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I16778253, https://openalex.org/I99542240 |
| authorships[1].institutions[0].country_code | PL |
| authorships[1].institutions[0].display_name | Instytut Biologii Doświadczalnej im. Marcelego Nenckiego |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Laura Turos-Korgul |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| authorships[2].author.id | https://openalex.org/A5055738653 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8655-851X |
| authorships[2].author.display_name | Ewa Kozłowska |
| authorships[2].countries | PL |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4654613 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Immunology, Institute of Functional Biology and Ecology, University of Warsaw, 02-096 Warsaw, Poland |
| authorships[2].institutions[0].id | https://openalex.org/I4654613 |
| authorships[2].institutions[0].ror | https://ror.org/039bjqg32 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4654613 |
| authorships[2].institutions[0].country_code | PL |
| authorships[2].institutions[0].display_name | University of Warsaw |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ewa Kozlowska |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Immunology, Institute of Functional Biology and Ecology, University of Warsaw, 02-096 Warsaw, Poland |
| authorships[3].author.id | https://openalex.org/A5065827194 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6676-5282 |
| authorships[3].author.display_name | Katarzyna Piwocka |
| authorships[3].countries | PL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I16778253 |
| authorships[3].affiliations[0].raw_affiliation_string | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| authorships[3].institutions[0].id | https://openalex.org/I16778253 |
| authorships[3].institutions[0].ror | https://ror.org/04waf7p94 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I16778253, https://openalex.org/I99542240 |
| authorships[3].institutions[0].country_code | PL |
| authorships[3].institutions[0].display_name | Instytut Biologii Doświadczalnej im. Marcelego Nenckiego |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Katarzyna Piwocka |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Laboratory of Cytometry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11313 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | Immune cells in cancer |
| related_works | https://openalex.org/W2121576596, https://openalex.org/W2787826327, https://openalex.org/W1902458417, https://openalex.org/W2012639655, https://openalex.org/W2027183754, https://openalex.org/W1968154930, https://openalex.org/W2375852010, https://openalex.org/W1977841877, https://openalex.org/W2561781137, https://openalex.org/W2115889659 |
| cited_by_count | 32 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 14 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 5 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 6 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 5 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/cancers13061203 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S168415115 |
| best_oa_location.source.issn | 2072-6694 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6694 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancers |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancers |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cancers13061203 |
| primary_location.id | doi:10.3390/cancers13061203 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S168415115 |
| primary_location.source.issn | 2072-6694 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6694 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancers |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2072-6694/13/6/1203/pdf?version=1615521895 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancers |
| primary_location.landing_page_url | https://doi.org/10.3390/cancers13061203 |
| publication_date | 2021-03-10 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2009886857, https://openalex.org/W2076922627, https://openalex.org/W1566520160, https://openalex.org/W3132068389, https://openalex.org/W2090982381, https://openalex.org/W2063486944, https://openalex.org/W2950655888, https://openalex.org/W2312894731, https://openalex.org/W3005797317, https://openalex.org/W2811083153, https://openalex.org/W2419140434, https://openalex.org/W3094802395, https://openalex.org/W3096606064, https://openalex.org/W2945763838, https://openalex.org/W3093553460, https://openalex.org/W2040981107, https://openalex.org/W2471542144, https://openalex.org/W2004180374, https://openalex.org/W2054449135, https://openalex.org/W2090757708, https://openalex.org/W1967358345, https://openalex.org/W2811405063, https://openalex.org/W2028824678, https://openalex.org/W2006445674, https://openalex.org/W2113752195, https://openalex.org/W2002213310, https://openalex.org/W3045946240, https://openalex.org/W3039313607, https://openalex.org/W2794872274, https://openalex.org/W2550255574, https://openalex.org/W2132053539, https://openalex.org/W2807706866, https://openalex.org/W3010133957, https://openalex.org/W2020242768, https://openalex.org/W2609414373, https://openalex.org/W2128871869, https://openalex.org/W218747224, https://openalex.org/W2551496057, https://openalex.org/W2039544976, https://openalex.org/W1964982854, https://openalex.org/W3041686036, https://openalex.org/W2809124723, https://openalex.org/W3002867455, https://openalex.org/W2606495925, https://openalex.org/W2000601828, https://openalex.org/W1978721974, https://openalex.org/W2938588657, https://openalex.org/W3093815480, https://openalex.org/W2086232358, https://openalex.org/W2767772633, https://openalex.org/W2564723173, https://openalex.org/W1970610464, https://openalex.org/W2053441255, https://openalex.org/W2912990831, https://openalex.org/W2150544967, https://openalex.org/W2975736685, https://openalex.org/W2071113689, https://openalex.org/W2071523891, https://openalex.org/W2095012072, https://openalex.org/W3046771604, https://openalex.org/W2948266360, https://openalex.org/W2044224425, https://openalex.org/W2050574097, https://openalex.org/W2982081358, https://openalex.org/W1993491016, https://openalex.org/W2057329290, https://openalex.org/W2619061518, https://openalex.org/W2776548546, https://openalex.org/W1906337113, https://openalex.org/W2559063149, https://openalex.org/W2767343890, https://openalex.org/W2981127240, https://openalex.org/W3011479969, https://openalex.org/W2167902402, https://openalex.org/W2035740887, https://openalex.org/W2002478729, https://openalex.org/W2153640125, https://openalex.org/W2510286120, https://openalex.org/W1975516216, https://openalex.org/W2064837930, https://openalex.org/W2985205513, https://openalex.org/W2982218867, https://openalex.org/W1544829530, https://openalex.org/W6608782621, https://openalex.org/W2959127920, https://openalex.org/W2149784748, https://openalex.org/W2476010535, https://openalex.org/W2053334450, https://openalex.org/W1681696483, https://openalex.org/W2472182739, https://openalex.org/W2239788766, https://openalex.org/W2175179979, https://openalex.org/W2470200249, https://openalex.org/W3115291370, https://openalex.org/W3081111966, https://openalex.org/W3047101097, https://openalex.org/W2805295196, https://openalex.org/W2593111137, https://openalex.org/W2384094940, https://openalex.org/W2103746815, https://openalex.org/W3001577527, https://openalex.org/W2097126393, https://openalex.org/W2032537701, https://openalex.org/W2801707126, https://openalex.org/W2011076421, https://openalex.org/W2102527135, https://openalex.org/W2205886515, https://openalex.org/W2550646651, https://openalex.org/W2068912461, https://openalex.org/W1983206315, https://openalex.org/W2110228704, https://openalex.org/W2014590681, https://openalex.org/W1984144180, https://openalex.org/W1734243119, https://openalex.org/W2083491998, https://openalex.org/W2115817713, https://openalex.org/W2764151634, https://openalex.org/W2904803868, https://openalex.org/W2963557097, https://openalex.org/W1973765711, https://openalex.org/W3024126283, https://openalex.org/W2008717037, https://openalex.org/W2144083071, https://openalex.org/W2081060988, https://openalex.org/W3032861598, https://openalex.org/W2151917704, https://openalex.org/W2773692579, https://openalex.org/W3015900989, https://openalex.org/W2028344677, https://openalex.org/W3003135273, https://openalex.org/W2980744106, https://openalex.org/W2747254185, https://openalex.org/W2160275670, https://openalex.org/W2891211189, https://openalex.org/W1554462930, https://openalex.org/W2031805423, https://openalex.org/W2121725913, https://openalex.org/W2934922729, https://openalex.org/W2766328237, https://openalex.org/W3109838559, https://openalex.org/W2117375925, https://openalex.org/W2966288630, https://openalex.org/W3084281103, https://openalex.org/W2990661613, https://openalex.org/W2772113180, https://openalex.org/W3038753161, https://openalex.org/W2580571122, https://openalex.org/W2896682958, https://openalex.org/W2914287288, https://openalex.org/W3029489073, https://openalex.org/W2805918213, https://openalex.org/W3009636168, https://openalex.org/W2516597671, https://openalex.org/W2792441886, https://openalex.org/W3087885195, https://openalex.org/W2773858712, https://openalex.org/W3005437667, https://openalex.org/W2513620066, https://openalex.org/W1992662011, https://openalex.org/W2917646500, https://openalex.org/W2552653135, https://openalex.org/W2550291749, https://openalex.org/W3010473572, https://openalex.org/W2102650038, https://openalex.org/W2740495409, https://openalex.org/W2980198543, https://openalex.org/W6784077172, https://openalex.org/W2139276258, https://openalex.org/W3085488459, https://openalex.org/W3032388391, https://openalex.org/W2951334807, https://openalex.org/W2119799287, https://openalex.org/W2128913157, https://openalex.org/W1534045109, https://openalex.org/W2903041954, https://openalex.org/W2981340069, https://openalex.org/W2073210353, https://openalex.org/W6782913628, https://openalex.org/W2001366995, https://openalex.org/W2083377487, https://openalex.org/W2062713220, https://openalex.org/W2063404733, https://openalex.org/W2112553705, https://openalex.org/W2466612052, https://openalex.org/W2402920549, https://openalex.org/W2893372497, https://openalex.org/W1976105607, https://openalex.org/W2031452237, https://openalex.org/W2804466413, https://openalex.org/W2780840511, https://openalex.org/W2782485041, https://openalex.org/W1855189531, https://openalex.org/W3112077104, https://openalex.org/W3037408501, https://openalex.org/W2974169670, https://openalex.org/W3048698172, https://openalex.org/W2808351116, https://openalex.org/W2982069065, https://openalex.org/W3008284415, https://openalex.org/W2470979010, https://openalex.org/W3123653170, https://openalex.org/W2054540776, https://openalex.org/W2035197415, https://openalex.org/W2259628957, https://openalex.org/W2972066599, https://openalex.org/W6729498892, https://openalex.org/W2474232167, https://openalex.org/W2905733679, https://openalex.org/W2984876778, https://openalex.org/W2231399813, https://openalex.org/W2100053995, https://openalex.org/W2004678195, https://openalex.org/W2621376045, https://openalex.org/W2557854027, https://openalex.org/W2899030939, https://openalex.org/W2144186438, https://openalex.org/W2735439261, https://openalex.org/W2799491649, https://openalex.org/W3094957162, https://openalex.org/W2161355389, https://openalex.org/W2794218805, https://openalex.org/W3021116030, https://openalex.org/W2989109767, https://openalex.org/W2142699991, https://openalex.org/W2900410545, https://openalex.org/W3021197377, https://openalex.org/W2808296583, https://openalex.org/W3048665145, https://openalex.org/W3048711673, https://openalex.org/W2550811157, https://openalex.org/W3092176826, https://openalex.org/W3092914411 |
| referenced_works_count | 232 |
| abstract_inverted_index.- | 109 |
| abstract_inverted_index.T | 37, 48, 111 |
| abstract_inverted_index.As | 18 |
| abstract_inverted_index.NK | 40 |
| abstract_inverted_index.as | 35, 132 |
| abstract_inverted_index.of | 31, 45, 59, 78, 105, 125 |
| abstract_inverted_index.on | 74 |
| abstract_inverted_index.or | 39 |
| abstract_inverted_index.to | 29 |
| abstract_inverted_index.we | 99, 120 |
| abstract_inverted_index.The | 70 |
| abstract_inverted_index.and | 4, 15, 50, 67, 93, 103, 117, 128, 136 |
| abstract_inverted_index.are | 96 |
| abstract_inverted_index.the | 9, 63 |
| abstract_inverted_index.– | 88 |
| abstract_inverted_index.Both | 0 |
| abstract_inverted_index.CD8+ | 36 |
| abstract_inverted_index.This | 54 |
| abstract_inverted_index.bone | 24, 64 |
| abstract_inverted_index.from | 85 |
| abstract_inverted_index.lead | 28 |
| abstract_inverted_index.main | 75, 106 |
| abstract_inverted_index.such | 34, 131 |
| abstract_inverted_index.they | 27 |
| abstract_inverted_index.acute | 5 |
| abstract_inverted_index.cells | 21, 38, 49, 87, 108, 116 |
| abstract_inverted_index.evade | 8 |
| abstract_inverted_index.niche | 66 |
| abstract_inverted_index.their | 13, 23 |
| abstract_inverted_index.blasts | 61 |
| abstract_inverted_index.cells, | 33, 41, 112 |
| abstract_inverted_index.cells. | 53 |
| abstract_inverted_index.during | 12 |
| abstract_inverted_index.immune | 10 |
| abstract_inverted_index.kinase | 134 |
| abstract_inverted_index.marrow | 25, 65 |
| abstract_inverted_index.modify | 22 |
| abstract_inverted_index.origin | 104 |
| abstract_inverted_index.review | 72 |
| abstract_inverted_index.analyze | 121 |
| abstract_inverted_index.between | 123 |
| abstract_inverted_index.chronic | 1 |
| abstract_inverted_index.derived | 83, 114 |
| abstract_inverted_index.disease | 16, 56 |
| abstract_inverted_index.factors | 82, 92 |
| abstract_inverted_index.focuses | 73 |
| abstract_inverted_index.myeloid | 2, 6, 19, 52, 79, 113 |
| abstract_inverted_index.outline | 100 |
| abstract_inverted_index.outside | 62 |
| abstract_inverted_index.soluble | 91 |
| abstract_inverted_index.therapy | 68 |
| abstract_inverted_index.Finally, | 119 |
| abstract_inverted_index.Firstly, | 81 |
| abstract_inverted_index.Further, | 98 |
| abstract_inverted_index.directly | 84 |
| abstract_inverted_index.effector | 126 |
| abstract_inverted_index.features | 77 |
| abstract_inverted_index.immunity | 127 |
| abstract_inverted_index.leukemia | 3, 7, 20 |
| abstract_inverted_index.leukemic | 60, 86 |
| abstract_inverted_index.recovery | 124 |
| abstract_inverted_index.response | 11 |
| abstract_inverted_index.tyrosine | 133 |
| abstract_inverted_index.cytotoxic | 32 |
| abstract_inverted_index.following | 71 |
| abstract_inverted_index.function, | 101 |
| abstract_inverted_index.interplay | 122 |
| abstract_inverted_index.promoting | 43 |
| abstract_inverted_index.spreading | 58 |
| abstract_inverted_index.vesicles, | 95 |
| abstract_inverted_index.described. | 97 |
| abstract_inverted_index.inhibitors | 135 |
| abstract_inverted_index.inhibitory | 89 |
| abstract_inverted_index.leukemias. | 80 |
| abstract_inverted_index.properties | 102 |
| abstract_inverted_index.receptors, | 90 |
| abstract_inverted_index.regulatory | 47, 110 |
| abstract_inverted_index.suppressor | 115 |
| abstract_inverted_index.development | 14, 44 |
| abstract_inverted_index.dysfunction | 30 |
| abstract_inverted_index.facilitates | 55 |
| abstract_inverted_index.modalities, | 130 |
| abstract_inverted_index.resistance. | 69 |
| abstract_inverted_index.suppressive | 51 |
| abstract_inverted_index.therapeutic | 129 |
| abstract_inverted_index.macrophages. | 118 |
| abstract_inverted_index.progression, | 57 |
| abstract_inverted_index.progression. | 17 |
| abstract_inverted_index.chemotherapy. | 137 |
| abstract_inverted_index.extracellular | 94 |
| abstract_inverted_index.simultaneously | 42 |
| abstract_inverted_index.immunosuppressive | 46, 76, 107 |
| abstract_inverted_index.microenvironment, | 26 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5065827194 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I16778253 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82183724 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |