Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyond Article Swipe
Andrea Ascione
,
Andrea Botticelli
,
Martina Leopizzi
,
Edoardo Cerbelli
,
Alessio Cirillo
,
Diana Bellavia
,
Carlo Della Rocca
,
Giulia d’Amati
,
Bruna Cerbelli
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.32074/1591-951x-1092
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.32074/1591-951x-1092
Head and neck squamous cell carcinoma (HNSCC) is a prominent global health concern because of its high incidence, aggressive clinical behavior, and scarce therapeutic options. The management of these neoplasms in the recurrent/metastatic setting has been revolutionized following the results of key clinical trials, leading to the advent of immunotherapeutic agents targeting the PD-1/PD-L1 axis. Despite the exciting results obtained with the new drugs, immunotherapy is helpful only in a sizable minority of patients, and there is a pressing need to identify reliable predictive biomarkers for patient selection. The immunohistochemical assessment of PD-L1 expression was initially identified as a powerful and easily accessible predictive tool, and gained its place as the current standard for patient selection, but it has clear limitations. The imperfect predictive power of PD-L1 has resulted in a strong effort to discover additional clinical, pathological and molecular biomarkers such as tumor HPV status, mutational burden, microsatellite instability, and much more. In addition, the tumor microenvironment has been extensively studied searching for promising new biomarkers as potential avenues for refining patient selection and improvement of treatment outcomes. As we gain deeper understanding of the complex interplay between tumor biology, immune system, and tumor microenvironment, we are rapidly realizing that the perfect biomarker, the magic bullet, probably doesn't exist. On the other hand, with the introduction of new drugs on the horizon, integration of multiple variables in the context of combined predictive scores is shaping up to be our best weapon in this strife to treat each patient with the best possible drug.
Related Topics
Concepts
Head and neck
Medicine
Immunotherapy
Head and neck squamous-cell carcinoma
Basal cell
Oncology
Cancer research
Internal medicine
Head and neck cancer
Radiation therapy
Cancer
Surgery
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.32074/1591-951x-1092
- https://www.pathologica.it/article/download/1344/722
- OA Status
- diamond
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411103720
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411103720Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.32074/1591-951x-1092Digital Object Identifier
- Title
-
Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyondWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-01Full publication date if available
- Authors
-
Andrea Ascione, Andrea Botticelli, Martina Leopizzi, Edoardo Cerbelli, Alessio Cirillo, Diana Bellavia, Carlo Della Rocca, Giulia d’Amati, Bruna CerbelliList of authors in order
- Landing page
-
https://doi.org/10.32074/1591-951x-1092Publisher landing page
- PDF URL
-
https://www.pathologica.it/article/download/1344/722Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.pathologica.it/article/download/1344/722Direct OA link when available
- Concepts
-
Head and neck, Medicine, Immunotherapy, Head and neck squamous-cell carcinoma, Basal cell, Oncology, Cancer research, Internal medicine, Head and neck cancer, Radiation therapy, Cancer, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
88Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411103720 |
|---|---|
| doi | https://doi.org/10.32074/1591-951x-1092 |
| ids.doi | https://doi.org/10.32074/1591-951x-1092 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40474706 |
| ids.openalex | https://openalex.org/W4411103720 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000628 |
| mesh[1].descriptor_ui | D000077195 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | therapy |
| mesh[1].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[2].qualifier_ui | Q000276 |
| mesh[2].descriptor_ui | D000077195 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | immunology |
| mesh[2].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[3].qualifier_ui | Q000473 |
| mesh[3].descriptor_ui | D000077195 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pathology |
| mesh[3].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[4].qualifier_ui | Q000188 |
| mesh[4].descriptor_ui | D000077195 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | drug therapy |
| mesh[4].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[5].qualifier_ui | Q000037 |
| mesh[5].descriptor_ui | D060890 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | antagonists & inhibitors |
| mesh[5].descriptor_name | B7-H1 Antigen |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D060890 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | B7-H1 Antigen |
| mesh[7].qualifier_ui | Q000276 |
| mesh[7].descriptor_ui | D060890 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | immunology |
| mesh[7].descriptor_name | B7-H1 Antigen |
| mesh[8].qualifier_ui | Q000379 |
| mesh[8].descriptor_ui | D007167 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | methods |
| mesh[8].descriptor_name | Immunotherapy |
| mesh[9].qualifier_ui | Q000473 |
| mesh[9].descriptor_ui | D009364 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | pathology |
| mesh[9].descriptor_name | Neoplasm Recurrence, Local |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D009364 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | Neoplasm Recurrence, Local |
| mesh[11].qualifier_ui | Q000473 |
| mesh[11].descriptor_ui | D006258 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | pathology |
| mesh[11].descriptor_name | Head and Neck Neoplasms |
| mesh[12].qualifier_ui | Q000276 |
| mesh[12].descriptor_ui | D006258 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | immunology |
| mesh[12].descriptor_name | Head and Neck Neoplasms |
| mesh[13].qualifier_ui | Q000628 |
| mesh[13].descriptor_ui | D006258 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | therapy |
| mesh[13].descriptor_name | Head and Neck Neoplasms |
| mesh[14].qualifier_ui | Q000276 |
| mesh[14].descriptor_ui | D059016 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | immunology |
| mesh[14].descriptor_name | Tumor Microenvironment |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D014408 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Biomarkers, Tumor |
| mesh[16].qualifier_ui | Q000627 |
| mesh[16].descriptor_ui | D000082082 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | therapeutic use |
| mesh[16].descriptor_name | Immune Checkpoint Inhibitors |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | Q000628 |
| mesh[18].descriptor_ui | D000077195 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | therapy |
| mesh[18].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[19].qualifier_ui | Q000276 |
| mesh[19].descriptor_ui | D000077195 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | immunology |
| mesh[19].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D000077195 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[21].qualifier_ui | Q000188 |
| mesh[21].descriptor_ui | D000077195 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | drug therapy |
| mesh[21].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[22].qualifier_ui | Q000037 |
| mesh[22].descriptor_ui | D060890 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | antagonists & inhibitors |
| mesh[22].descriptor_name | B7-H1 Antigen |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D060890 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | B7-H1 Antigen |
| mesh[24].qualifier_ui | Q000276 |
| mesh[24].descriptor_ui | D060890 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | immunology |
| mesh[24].descriptor_name | B7-H1 Antigen |
| mesh[25].qualifier_ui | Q000379 |
| mesh[25].descriptor_ui | D007167 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | methods |
| mesh[25].descriptor_name | Immunotherapy |
| mesh[26].qualifier_ui | Q000473 |
| mesh[26].descriptor_ui | D009364 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | pathology |
| mesh[26].descriptor_name | Neoplasm Recurrence, Local |
| mesh[27].qualifier_ui | Q000276 |
| mesh[27].descriptor_ui | D009364 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | immunology |
| mesh[27].descriptor_name | Neoplasm Recurrence, Local |
| mesh[28].qualifier_ui | Q000473 |
| mesh[28].descriptor_ui | D006258 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | pathology |
| mesh[28].descriptor_name | Head and Neck Neoplasms |
| mesh[29].qualifier_ui | Q000276 |
| mesh[29].descriptor_ui | D006258 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | immunology |
| mesh[29].descriptor_name | Head and Neck Neoplasms |
| mesh[30].qualifier_ui | Q000628 |
| mesh[30].descriptor_ui | D006258 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | therapy |
| mesh[30].descriptor_name | Head and Neck Neoplasms |
| mesh[31].qualifier_ui | Q000276 |
| mesh[31].descriptor_ui | D059016 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | immunology |
| mesh[31].descriptor_name | Tumor Microenvironment |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D014408 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Biomarkers, Tumor |
| mesh[33].qualifier_ui | Q000627 |
| mesh[33].descriptor_ui | D000082082 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | therapeutic use |
| mesh[33].descriptor_name | Immune Checkpoint Inhibitors |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D006801 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Humans |
| mesh[35].qualifier_ui | Q000628 |
| mesh[35].descriptor_ui | D000077195 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | therapy |
| mesh[35].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[36].qualifier_ui | Q000276 |
| mesh[36].descriptor_ui | D000077195 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | immunology |
| mesh[36].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[37].qualifier_ui | Q000473 |
| mesh[37].descriptor_ui | D000077195 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pathology |
| mesh[37].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[38].qualifier_ui | Q000188 |
| mesh[38].descriptor_ui | D000077195 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | drug therapy |
| mesh[38].descriptor_name | Squamous Cell Carcinoma of Head and Neck |
| mesh[39].qualifier_ui | Q000037 |
| mesh[39].descriptor_ui | D060890 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | antagonists & inhibitors |
| mesh[39].descriptor_name | B7-H1 Antigen |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D060890 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | B7-H1 Antigen |
| mesh[41].qualifier_ui | Q000276 |
| mesh[41].descriptor_ui | D060890 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | immunology |
| mesh[41].descriptor_name | B7-H1 Antigen |
| mesh[42].qualifier_ui | Q000379 |
| mesh[42].descriptor_ui | D007167 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | methods |
| mesh[42].descriptor_name | Immunotherapy |
| mesh[43].qualifier_ui | Q000473 |
| mesh[43].descriptor_ui | D009364 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | pathology |
| mesh[43].descriptor_name | Neoplasm Recurrence, Local |
| mesh[44].qualifier_ui | Q000276 |
| mesh[44].descriptor_ui | D009364 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | immunology |
| mesh[44].descriptor_name | Neoplasm Recurrence, Local |
| mesh[45].qualifier_ui | Q000473 |
| mesh[45].descriptor_ui | D006258 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | pathology |
| mesh[45].descriptor_name | Head and Neck Neoplasms |
| mesh[46].qualifier_ui | Q000276 |
| mesh[46].descriptor_ui | D006258 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | immunology |
| mesh[46].descriptor_name | Head and Neck Neoplasms |
| mesh[47].qualifier_ui | Q000628 |
| mesh[47].descriptor_ui | D006258 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | therapy |
| mesh[47].descriptor_name | Head and Neck Neoplasms |
| mesh[48].qualifier_ui | Q000276 |
| mesh[48].descriptor_ui | D059016 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | immunology |
| mesh[48].descriptor_name | Tumor Microenvironment |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D014408 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Biomarkers, Tumor |
| type | article |
| title | Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyond |
| biblio.issue | 2 |
| biblio.volume | 117 |
| biblio.last_page | 83 |
| biblio.first_page | 73 |
| topics[0].id | https://openalex.org/T10158 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Cancer Immunotherapy and Biomarkers |
| topics[1].id | https://openalex.org/T10307 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9997000098228455 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2733 |
| topics[1].subfield.display_name | Otorhinolaryngology |
| topics[1].display_name | Head and Neck Cancer Studies |
| topics[2].id | https://openalex.org/T12334 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9993000030517578 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Lung Cancer Research Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C3018411727 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7429125308990479 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3867488 |
| concepts[0].display_name | Head and neck |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.730206310749054 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2777701055 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7244488000869751 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[2].display_name | Immunotherapy |
| concepts[3].id | https://openalex.org/C2776833033 |
| concepts[3].level | 4 |
| concepts[3].score | 0.6794718503952026 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1783924 |
| concepts[3].display_name | Head and neck squamous-cell carcinoma |
| concepts[4].id | https://openalex.org/C3019992690 |
| concepts[4].level | 2 |
| concepts[4].score | 0.616929292678833 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q92767510 |
| concepts[4].display_name | Basal cell |
| concepts[5].id | https://openalex.org/C143998085 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5321138501167297 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[5].display_name | Oncology |
| concepts[6].id | https://openalex.org/C502942594 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4437626004219055 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[6].display_name | Cancer research |
| concepts[7].id | https://openalex.org/C126322002 |
| concepts[7].level | 1 |
| concepts[7].score | 0.42886772751808167 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[7].display_name | Internal medicine |
| concepts[8].id | https://openalex.org/C2776530083 |
| concepts[8].level | 3 |
| concepts[8].score | 0.34346020221710205 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1783924 |
| concepts[8].display_name | Head and neck cancer |
| concepts[9].id | https://openalex.org/C509974204 |
| concepts[9].level | 2 |
| concepts[9].score | 0.1797732710838318 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q180507 |
| concepts[9].display_name | Radiation therapy |
| concepts[10].id | https://openalex.org/C121608353 |
| concepts[10].level | 2 |
| concepts[10].score | 0.10867619514465332 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[10].display_name | Cancer |
| concepts[11].id | https://openalex.org/C141071460 |
| concepts[11].level | 1 |
| concepts[11].score | 0.1072811484336853 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[11].display_name | Surgery |
| keywords[0].id | https://openalex.org/keywords/head-and-neck |
| keywords[0].score | 0.7429125308990479 |
| keywords[0].display_name | Head and neck |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.730206310749054 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/immunotherapy |
| keywords[2].score | 0.7244488000869751 |
| keywords[2].display_name | Immunotherapy |
| keywords[3].id | https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma |
| keywords[3].score | 0.6794718503952026 |
| keywords[3].display_name | Head and neck squamous-cell carcinoma |
| keywords[4].id | https://openalex.org/keywords/basal-cell |
| keywords[4].score | 0.616929292678833 |
| keywords[4].display_name | Basal cell |
| keywords[5].id | https://openalex.org/keywords/oncology |
| keywords[5].score | 0.5321138501167297 |
| keywords[5].display_name | Oncology |
| keywords[6].id | https://openalex.org/keywords/cancer-research |
| keywords[6].score | 0.4437626004219055 |
| keywords[6].display_name | Cancer research |
| keywords[7].id | https://openalex.org/keywords/internal-medicine |
| keywords[7].score | 0.42886772751808167 |
| keywords[7].display_name | Internal medicine |
| keywords[8].id | https://openalex.org/keywords/head-and-neck-cancer |
| keywords[8].score | 0.34346020221710205 |
| keywords[8].display_name | Head and neck cancer |
| keywords[9].id | https://openalex.org/keywords/radiation-therapy |
| keywords[9].score | 0.1797732710838318 |
| keywords[9].display_name | Radiation therapy |
| keywords[10].id | https://openalex.org/keywords/cancer |
| keywords[10].score | 0.10867619514465332 |
| keywords[10].display_name | Cancer |
| keywords[11].id | https://openalex.org/keywords/surgery |
| keywords[11].score | 0.1072811484336853 |
| keywords[11].display_name | Surgery |
| language | en |
| locations[0].id | doi:10.32074/1591-951x-1092 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S19103007 |
| locations[0].source.issn | 0031-2983, 1591-951X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0031-2983 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Pathologica |
| locations[0].source.host_organization | https://openalex.org/P4323237951 |
| locations[0].source.host_organization_name | Pacini Editore |
| locations[0].source.host_organization_lineage | https://openalex.org/P4323237951 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.pathologica.it/article/download/1344/722 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pathologica |
| locations[0].landing_page_url | https://doi.org/10.32074/1591-951x-1092 |
| locations[1].id | pmid:40474706 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pathologica |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40474706 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12142288 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Pathologica |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12142288 |
| locations[3].id | pmh:oai:iris.uniroma1.it:11573/1741379 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4377196107 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | IRIS Research product catalog (Sapienza University of Rome) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://hdl.handle.net/11573/1741379 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5083296652 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4253-3193 |
| authorships[0].author.display_name | Andrea Ascione |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Sapienza, University of Rome, Rome, Italy. |
| authorships[0].institutions[0].id | https://openalex.org/I861853513 |
| authorships[0].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Sapienza University of Rome |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Andrea Ascione |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Experimental Medicine, Sapienza, University of Rome, Rome, Italy. |
| authorships[1].author.id | https://openalex.org/A5025723323 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6425-9893 |
| authorships[1].author.display_name | Andrea Botticelli |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[1].institutions[0].id | https://openalex.org/I861853513 |
| authorships[1].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Sapienza University of Rome |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Andrea Botticelli |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[2].author.id | https://openalex.org/A5086890371 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9258-4191 |
| authorships[2].author.display_name | Martina Leopizzi |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| authorships[2].institutions[0].id | https://openalex.org/I861853513 |
| authorships[2].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Sapienza University of Rome |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Martina Leopizzi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| authorships[3].author.id | https://openalex.org/A5088822060 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Edoardo Cerbelli |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Sapienza, University of Rome, Rome, Italy. |
| authorships[3].institutions[0].id | https://openalex.org/I861853513 |
| authorships[3].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Sapienza University of Rome |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Edoardo Cerbelli |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Experimental Medicine, Sapienza, University of Rome, Rome, Italy. |
| authorships[4].author.id | https://openalex.org/A5009650068 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0449-9569 |
| authorships[4].author.display_name | Alessio Cirillo |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[4].institutions[0].id | https://openalex.org/I861853513 |
| authorships[4].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | Sapienza University of Rome |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Alessio Cirillo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[5].author.id | https://openalex.org/A5013703740 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5728-2537 |
| authorships[5].author.display_name | Diana Bellavia |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. |
| authorships[5].institutions[0].id | https://openalex.org/I861853513 |
| authorships[5].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Sapienza University of Rome |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Diana Bellavia |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. |
| authorships[6].author.id | https://openalex.org/A5103197818 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7176-5217 |
| authorships[6].author.display_name | Carlo Della Rocca |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| authorships[6].institutions[0].id | https://openalex.org/I861853513 |
| authorships[6].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | Sapienza University of Rome |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Carlo Della Rocca |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| authorships[7].author.id | https://openalex.org/A5057472776 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6959-691X |
| authorships[7].author.display_name | Giulia d’Amati |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[7].institutions[0].id | https://openalex.org/I861853513 |
| authorships[7].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | Sapienza University of Rome |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Giulia d'Amati |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Radiology, Oncology and Pathology, Sapienza, University of Rome, Rome, Italy. |
| authorships[8].author.id | https://openalex.org/A5020744280 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-5419-2309 |
| authorships[8].author.display_name | Bruna Cerbelli |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| authorships[8].institutions[0].id | https://openalex.org/I861853513 |
| authorships[8].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Sapienza University of Rome |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Bruna Cerbelli |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.pathologica.it/article/download/1344/722 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyond |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10158 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Cancer Immunotherapy and Biomarkers |
| related_works | https://openalex.org/W3029386772, https://openalex.org/W3159716479, https://openalex.org/W1976054954, https://openalex.org/W3138359172, https://openalex.org/W3082172371, https://openalex.org/W1980398461, https://openalex.org/W3217171965, https://openalex.org/W2409976101, https://openalex.org/W1991628107, https://openalex.org/W4293207130 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.32074/1591-951x-1092 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S19103007 |
| best_oa_location.source.issn | 0031-2983, 1591-951X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0031-2983 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Pathologica |
| best_oa_location.source.host_organization | https://openalex.org/P4323237951 |
| best_oa_location.source.host_organization_name | Pacini Editore |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4323237951 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.pathologica.it/article/download/1344/722 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pathologica |
| best_oa_location.landing_page_url | https://doi.org/10.32074/1591-951x-1092 |
| primary_location.id | doi:10.32074/1591-951x-1092 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S19103007 |
| primary_location.source.issn | 0031-2983, 1591-951X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0031-2983 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Pathologica |
| primary_location.source.host_organization | https://openalex.org/P4323237951 |
| primary_location.source.host_organization_name | Pacini Editore |
| primary_location.source.host_organization_lineage | https://openalex.org/P4323237951 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.pathologica.it/article/download/1344/722 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pathologica |
| primary_location.landing_page_url | https://doi.org/10.32074/1591-951x-1092 |
| publication_date | 2025-05-01 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3128646645, https://openalex.org/W3124914776, https://openalex.org/W3039051942, https://openalex.org/W1989754098, https://openalex.org/W2911188335, https://openalex.org/W3189212793, https://openalex.org/W2112845420, https://openalex.org/W3134959030, https://openalex.org/W2913158592, https://openalex.org/W4223543379, https://openalex.org/W2799553179, https://openalex.org/W4380323527, https://openalex.org/W4281922328, https://openalex.org/W2401455386, https://openalex.org/W2529484692, https://openalex.org/W3196817178, https://openalex.org/W2124462445, https://openalex.org/W4244183395, https://openalex.org/W3181752997, https://openalex.org/W3047406790, https://openalex.org/W2958648554, https://openalex.org/W4226329559, https://openalex.org/W2901903079, https://openalex.org/W3107686376, https://openalex.org/W3167114692, https://openalex.org/W3047138337, https://openalex.org/W3197800612, https://openalex.org/W4213298736, https://openalex.org/W4292590106, https://openalex.org/W3198186549, https://openalex.org/W4223998743, https://openalex.org/W3162000319, https://openalex.org/W2884949281, https://openalex.org/W4388421024, https://openalex.org/W3169335786, https://openalex.org/W4288056478, https://openalex.org/W3189274400, https://openalex.org/W2983683684, https://openalex.org/W2978209487, https://openalex.org/W3097803258, https://openalex.org/W4210362744, https://openalex.org/W3165537737, https://openalex.org/W4391521816, https://openalex.org/W2788797147, https://openalex.org/W4311670945, https://openalex.org/W2622499649, https://openalex.org/W3093042431, https://openalex.org/W1986541190, https://openalex.org/W2796123511, https://openalex.org/W2076029531, https://openalex.org/W4323566227, https://openalex.org/W3141004240, https://openalex.org/W4393344648, https://openalex.org/W1859257957, https://openalex.org/W2744685612, https://openalex.org/W2120431466, https://openalex.org/W4220905116, https://openalex.org/W2537963082, https://openalex.org/W2506561330, https://openalex.org/W1970151745, https://openalex.org/W2001087320, https://openalex.org/W2561388072, https://openalex.org/W3200816639, https://openalex.org/W4378219596, https://openalex.org/W2981524284, https://openalex.org/W3024359147, https://openalex.org/W4311610526, https://openalex.org/W4321786945, https://openalex.org/W4400105776, https://openalex.org/W4309317193, https://openalex.org/W3164178299, https://openalex.org/W2887169335, https://openalex.org/W2981030158, https://openalex.org/W4214568242, https://openalex.org/W4391344960, https://openalex.org/W4283794101, https://openalex.org/W4220857832, https://openalex.org/W4385161729, https://openalex.org/W2766621662, https://openalex.org/W4385840760, https://openalex.org/W4365146753, https://openalex.org/W2797675217, https://openalex.org/W4293103564, https://openalex.org/W3081548621, https://openalex.org/W4386126487, https://openalex.org/W2765314233, https://openalex.org/W2740073617, https://openalex.org/W3032193845 |
| referenced_works_count | 88 |
| abstract_inverted_index.a | 8, 69, 77, 98, 130 |
| abstract_inverted_index.As | 179 |
| abstract_inverted_index.In | 153 |
| abstract_inverted_index.On | 210 |
| abstract_inverted_index.as | 97, 109, 142, 167 |
| abstract_inverted_index.be | 238 |
| abstract_inverted_index.in | 30, 68, 129, 227, 242 |
| abstract_inverted_index.is | 7, 65, 76, 234 |
| abstract_inverted_index.it | 117 |
| abstract_inverted_index.of | 14, 27, 40, 48, 72, 91, 125, 176, 184, 217, 224, 230 |
| abstract_inverted_index.on | 220 |
| abstract_inverted_index.to | 45, 80, 133, 237, 245 |
| abstract_inverted_index.up | 236 |
| abstract_inverted_index.we | 180, 196 |
| abstract_inverted_index.HPV | 144 |
| abstract_inverted_index.The | 25, 88, 121 |
| abstract_inverted_index.and | 1, 21, 74, 100, 105, 138, 150, 174, 193 |
| abstract_inverted_index.are | 197 |
| abstract_inverted_index.but | 116 |
| abstract_inverted_index.for | 85, 113, 163, 170 |
| abstract_inverted_index.has | 34, 118, 127, 158 |
| abstract_inverted_index.its | 15, 107 |
| abstract_inverted_index.key | 41 |
| abstract_inverted_index.new | 62, 165, 218 |
| abstract_inverted_index.our | 239 |
| abstract_inverted_index.the | 31, 38, 46, 52, 56, 61, 110, 155, 185, 201, 204, 211, 215, 221, 228, 250 |
| abstract_inverted_index.was | 94 |
| abstract_inverted_index.Head | 0 |
| abstract_inverted_index.been | 35, 159 |
| abstract_inverted_index.best | 240, 251 |
| abstract_inverted_index.cell | 4 |
| abstract_inverted_index.each | 247 |
| abstract_inverted_index.gain | 181 |
| abstract_inverted_index.high | 16 |
| abstract_inverted_index.much | 151 |
| abstract_inverted_index.neck | 2 |
| abstract_inverted_index.need | 79 |
| abstract_inverted_index.only | 67 |
| abstract_inverted_index.such | 141 |
| abstract_inverted_index.that | 200 |
| abstract_inverted_index.this | 243 |
| abstract_inverted_index.with | 60, 214, 249 |
| abstract_inverted_index.PD-L1 | 92, 126 |
| abstract_inverted_index.axis. | 54 |
| abstract_inverted_index.clear | 119 |
| abstract_inverted_index.drug. | 253 |
| abstract_inverted_index.drugs | 219 |
| abstract_inverted_index.hand, | 213 |
| abstract_inverted_index.magic | 205 |
| abstract_inverted_index.more. | 152 |
| abstract_inverted_index.other | 212 |
| abstract_inverted_index.place | 108 |
| abstract_inverted_index.power | 124 |
| abstract_inverted_index.there | 75 |
| abstract_inverted_index.these | 28 |
| abstract_inverted_index.tool, | 104 |
| abstract_inverted_index.treat | 246 |
| abstract_inverted_index.tumor | 143, 156, 189, 194 |
| abstract_inverted_index.advent | 47 |
| abstract_inverted_index.agents | 50 |
| abstract_inverted_index.deeper | 182 |
| abstract_inverted_index.drugs, | 63 |
| abstract_inverted_index.easily | 101 |
| abstract_inverted_index.effort | 132 |
| abstract_inverted_index.exist. | 209 |
| abstract_inverted_index.gained | 106 |
| abstract_inverted_index.global | 10 |
| abstract_inverted_index.health | 11 |
| abstract_inverted_index.immune | 191 |
| abstract_inverted_index.scarce | 22 |
| abstract_inverted_index.scores | 233 |
| abstract_inverted_index.strife | 244 |
| abstract_inverted_index.strong | 131 |
| abstract_inverted_index.weapon | 241 |
| abstract_inverted_index.(HNSCC) | 6 |
| abstract_inverted_index.Despite | 55 |
| abstract_inverted_index.avenues | 169 |
| abstract_inverted_index.because | 13 |
| abstract_inverted_index.between | 188 |
| abstract_inverted_index.bullet, | 206 |
| abstract_inverted_index.burden, | 147 |
| abstract_inverted_index.complex | 186 |
| abstract_inverted_index.concern | 12 |
| abstract_inverted_index.context | 229 |
| abstract_inverted_index.current | 111 |
| abstract_inverted_index.doesn't | 208 |
| abstract_inverted_index.helpful | 66 |
| abstract_inverted_index.leading | 44 |
| abstract_inverted_index.patient | 86, 114, 172, 248 |
| abstract_inverted_index.perfect | 202 |
| abstract_inverted_index.rapidly | 198 |
| abstract_inverted_index.results | 39, 58 |
| abstract_inverted_index.setting | 33 |
| abstract_inverted_index.shaping | 235 |
| abstract_inverted_index.sizable | 70 |
| abstract_inverted_index.status, | 145 |
| abstract_inverted_index.studied | 161 |
| abstract_inverted_index.system, | 192 |
| abstract_inverted_index.trials, | 43 |
| abstract_inverted_index.biology, | 190 |
| abstract_inverted_index.clinical | 19, 42 |
| abstract_inverted_index.combined | 231 |
| abstract_inverted_index.discover | 134 |
| abstract_inverted_index.exciting | 57 |
| abstract_inverted_index.horizon, | 222 |
| abstract_inverted_index.identify | 81 |
| abstract_inverted_index.minority | 71 |
| abstract_inverted_index.multiple | 225 |
| abstract_inverted_index.obtained | 59 |
| abstract_inverted_index.options. | 24 |
| abstract_inverted_index.possible | 252 |
| abstract_inverted_index.powerful | 99 |
| abstract_inverted_index.pressing | 78 |
| abstract_inverted_index.probably | 207 |
| abstract_inverted_index.refining | 171 |
| abstract_inverted_index.reliable | 82 |
| abstract_inverted_index.resulted | 128 |
| abstract_inverted_index.squamous | 3 |
| abstract_inverted_index.standard | 112 |
| abstract_inverted_index.addition, | 154 |
| abstract_inverted_index.behavior, | 20 |
| abstract_inverted_index.carcinoma | 5 |
| abstract_inverted_index.clinical, | 136 |
| abstract_inverted_index.following | 37 |
| abstract_inverted_index.imperfect | 122 |
| abstract_inverted_index.initially | 95 |
| abstract_inverted_index.interplay | 187 |
| abstract_inverted_index.molecular | 139 |
| abstract_inverted_index.neoplasms | 29 |
| abstract_inverted_index.outcomes. | 178 |
| abstract_inverted_index.patients, | 73 |
| abstract_inverted_index.potential | 168 |
| abstract_inverted_index.prominent | 9 |
| abstract_inverted_index.promising | 164 |
| abstract_inverted_index.realizing | 199 |
| abstract_inverted_index.searching | 162 |
| abstract_inverted_index.selection | 173 |
| abstract_inverted_index.targeting | 51 |
| abstract_inverted_index.treatment | 177 |
| abstract_inverted_index.variables | 226 |
| abstract_inverted_index.PD-1/PD-L1 | 53 |
| abstract_inverted_index.accessible | 102 |
| abstract_inverted_index.additional | 135 |
| abstract_inverted_index.aggressive | 18 |
| abstract_inverted_index.assessment | 90 |
| abstract_inverted_index.biomarker, | 203 |
| abstract_inverted_index.biomarkers | 84, 140, 166 |
| abstract_inverted_index.expression | 93 |
| abstract_inverted_index.identified | 96 |
| abstract_inverted_index.incidence, | 17 |
| abstract_inverted_index.management | 26 |
| abstract_inverted_index.mutational | 146 |
| abstract_inverted_index.predictive | 83, 103, 123, 232 |
| abstract_inverted_index.selection, | 115 |
| abstract_inverted_index.selection. | 87 |
| abstract_inverted_index.extensively | 160 |
| abstract_inverted_index.improvement | 175 |
| abstract_inverted_index.integration | 223 |
| abstract_inverted_index.therapeutic | 23 |
| abstract_inverted_index.instability, | 149 |
| abstract_inverted_index.introduction | 216 |
| abstract_inverted_index.limitations. | 120 |
| abstract_inverted_index.pathological | 137 |
| abstract_inverted_index.immunotherapy | 64 |
| abstract_inverted_index.understanding | 183 |
| abstract_inverted_index.microsatellite | 148 |
| abstract_inverted_index.revolutionized | 36 |
| abstract_inverted_index.microenvironment | 157 |
| abstract_inverted_index.immunotherapeutic | 49 |
| abstract_inverted_index.microenvironment, | 195 |
| abstract_inverted_index.immunohistochemical | 89 |
| abstract_inverted_index.recurrent/metastatic | 32 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.3139593 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |