BMJ Open • Vol 13 • No 9
Impact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial
September 2023 • Júlia Montenegro, Camila L. P. Oliveira, Anissa M. Armet, Aloys Berg, Arya M. Sharma, Laurie Mereu, Cristiane Cominetti, Sunita Ghosh, Caroline Richa…
Introduction Excess body weight is associated with a state of low-grade chronic inflammation and alterations of the gut microbiome. Powdered meal replacements (PMR) have been shown to be an effective strategy for weight management; however, their effect on inflammation and the gut microbiome remains unclear. The aim of this 12-week randomised control clinical trial is to investigate the effects of PMR consumption, here given as a soy-yoghurt-honey formula, on inflammation, gut microbiome and overall metabolism in …