Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX ‐AHF ‐2 trial
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· 2024
· Open Access
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· DOI: https://doi.org/10.1002/ejhf.3451
Aims Acute heart failure (AHF) is a major cause of hospitalizations and death in the elderly. However, elderly patients are often underrepresented in randomized clinical trials. We analysed the impact of age on clinical outcomes and response to treatment in patients enrolled in Relaxin in Acute Heart Failure (RELAX‐AHF‐2), a study that included older patients than in previous AHF trials. Methods and results The RELAX‐AHF‐2 randomized patients admitted for AHF to infusion of serelaxin or placebo. We examined the association of pre‐specified clinical outcomes and treatment effect according to age categories [(years): 0.05). Conclusion Elderly patients are at higher risk of short‐ and long‐term CV outcomes after a hospitalization for AHF. Further efforts are needed to improve CV outcomes in this population.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ejhf.3451
- OA Status
- green
- Cited By
- 1
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402310087
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402310087Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ejhf.3451Digital Object Identifier
- Title
-
Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the
RELAX ‐AHF ‐2 trialWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-06Full publication date if available
- Authors
-
Riccardo M. Inciardi, Laura Staal, Beth A. Davison, Carlo Lombardi, Douwe Postmus, G. Michael Felker, Gerasimos Filippatos, Barry Greenberg, Peter S. Pang, Piotr Ponikowski, Thomas Severin, Claudio Gimpelewicz, John Teerlink, Gad Cotter, Adriaan A. Voors, Marco MetraList of authors in order
- Landing page
-
https://doi.org/10.1002/ejhf.3451Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11659486Direct OA link when available
- Concepts
-
Medicine, Heart failure, Clinical endpoint, Placebo, Clinical trial, Internal medicine, Confounding, Randomized controlled trial, Cardiology, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
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23Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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