Impact of APOE and BDNF Val66Met polymorphisms on spatial navigation and brain morphometry in subjective cognitive decline Article Swipe
Jan Laczó
,
Kateřina Čechová
,
Martina Pařízková
,
Ondřej Lerch
,
Václav Maťoška
,
Vojtěch Kaplan
,
Veronika Matušková
,
Hana Marková
,
Zuzana Nedelská
,
Martin Vyhnálek
,
Jakub Hort
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/alz.050927
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/alz.050927
Background The apolipoprotein E ( APOE ) ɛ4 allele is associated with episodic memory deficits, less accurate spatial navigation and hippocampal atrophy in nondemented older adults. The brain‐derived neurotrophic factor ( BDNF ) Met allele may further worsen memory impairment and reduce hippocampal activation in APOE ɛ4 carriers but its role in APOE ɛ4‐related spatial navigation deficits has not been established. We aimed to evaluate the influence of combination of the APOE and BDNF Val66Met polymorphisms on spatial navigation, cognitive functions and volumes of selected brain regions associated with spatial navigation including the hippocampus, entorhinal cortex, precuneus, inferior parietal and posterior cingulate cortex in individuals with subjective cognitive decline (SCD). Method In total, 71 older adults with SCD from the Czech Brain Aging Study were stratified based on the APOE and BDNF Val66Met polymorphisms into four groups: ɛ4 – / BDNF Val/Val (n =27), ɛ4 – / BDNF Met (n = 15), ɛ4 + / BDNF Val/Val (n =18), and ɛ4 + / BDNF Met (n=11). The participants underwent comprehensive neuropsychological examination, brain MRI and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real‐space human analogue of the Morris water maze. Result The ɛ4 + / BDNF Met group, although similar to other polymorphism groups in age, gender, education, depressive symptoms and global cognitive function, had less accurate allocentric and allocentric delayed navigation performance than the ɛ4–/BDNF Val/Val group (p<0.05). There were no significant differences in egocentric navigation performance, cognitive performance in any cognitive domain including attention and working memory, nonverbal memory, executive function, language and visuospatial function and volumes of selected brain regions associated with spatial navigation between the polymorphism groups (p>0.05). Conclusion Individuals with SCD and the high risk combination of APOE ɛ4 and BDNF Met alleles had less accurate allocentric spatial navigation than those with the low risk combination of APOE ɛ3 and BDNF Val alleles. This finding may indicate that individuals with SCD and two high risk gene polymorphisms are particularly susceptible to hippocampus‐dependent spatial navigation deficits and may be at greater risk of cognitive decline and progression to mild cognitive impairment. Our results also suggest that spatial navigation testing could more reliably assess the deleterious effect of the BDNF Met allele on cognition than other cognitive tests.
Related Topics
Concepts
Psychology
Precuneus
Apolipoprotein E
Spatial memory
Episodic memory
Neuroscience
Brain-derived neurotrophic factor
Cognition
Hippocampus
Entorhinal cortex
Posterior cingulate
Audiology
Neurotrophic factors
Medicine
Working memory
Internal medicine
Receptor
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.050927
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.050927
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4205927175
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4205927175Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/alz.050927Digital Object Identifier
- Title
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Impact of APOE and BDNF Val66Met polymorphisms on spatial navigation and brain morphometry in subjective cognitive declineWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-01Full publication date if available
- Authors
-
Jan Laczó, Kateřina Čechová, Martina Pařízková, Ondřej Lerch, Václav Maťoška, Vojtěch Kaplan, Veronika Matušková, Hana Marková, Zuzana Nedelská, Martin Vyhnálek, Jakub HortList of authors in order
- Landing page
-
https://doi.org/10.1002/alz.050927Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.050927Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.050927Direct OA link when available
- Concepts
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Psychology, Precuneus, Apolipoprotein E, Spatial memory, Episodic memory, Neuroscience, Brain-derived neurotrophic factor, Cognition, Hippocampus, Entorhinal cortex, Posterior cingulate, Audiology, Neurotrophic factors, Medicine, Working memory, Internal medicine, Receptor, DiseaseTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.regions | 87, 268 |
| abstract_inverted_index.results | 352 |
| abstract_inverted_index.similar | 205 |
| abstract_inverted_index.spatial | 18, 55, 78, 90, 176, 271, 298, 333, 356 |
| abstract_inverted_index.suggest | 354 |
| abstract_inverted_index.testing | 178, 358 |
| abstract_inverted_index.volumes | 83, 264 |
| abstract_inverted_index.working | 253 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Val66Met | 75, 133 |
| abstract_inverted_index.accurate | 17, 222, 296 |
| abstract_inverted_index.alleles. | 313 |
| abstract_inverted_index.although | 204 |
| abstract_inverted_index.analogue | 190 |
| abstract_inverted_index.carriers | 48 |
| abstract_inverted_index.deficits | 57, 335 |
| abstract_inverted_index.episodic | 13 |
| abstract_inverted_index.evaluate | 65 |
| abstract_inverted_index.function | 262 |
| abstract_inverted_index.indicate | 317 |
| abstract_inverted_index.inferior | 98 |
| abstract_inverted_index.language | 259 |
| abstract_inverted_index.parietal | 99 |
| abstract_inverted_index.reliably | 361 |
| abstract_inverted_index.selected | 85, 266 |
| abstract_inverted_index.symptoms | 215 |
| abstract_inverted_index.attention | 251 |
| abstract_inverted_index.cingulate | 102 |
| abstract_inverted_index.cognition | 372 |
| abstract_inverted_index.cognitive | 80, 108, 218, 244, 248, 343, 349, 375 |
| abstract_inverted_index.deficits, | 15 |
| abstract_inverted_index.executive | 257 |
| abstract_inverted_index.function, | 219, 258 |
| abstract_inverted_index.functions | 81 |
| abstract_inverted_index.including | 92, 250 |
| abstract_inverted_index.influence | 67 |
| abstract_inverted_index.nonverbal | 255 |
| abstract_inverted_index.posterior | 101 |
| abstract_inverted_index.underwent | 169 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 278 |
| abstract_inverted_index.activation | 44 |
| abstract_inverted_index.associated | 11, 88, 269 |
| abstract_inverted_index.depressive | 214 |
| abstract_inverted_index.education, | 213 |
| abstract_inverted_index.egocentric | 241 |
| abstract_inverted_index.entorhinal | 95 |
| abstract_inverted_index.impairment | 40 |
| abstract_inverted_index.navigation | 19, 56, 91, 177, 185, 227, 242, 272, 299, 334, 357 |
| abstract_inverted_index.precuneus, | 97 |
| abstract_inverted_index.stratified | 126 |
| abstract_inverted_index.subjective | 107 |
| abstract_inverted_index.Individuals | 279 |
| abstract_inverted_index.allocentric | 183, 223, 225, 297 |
| abstract_inverted_index.combination | 69, 286, 306 |
| abstract_inverted_index.deleterious | 364 |
| abstract_inverted_index.differences | 239 |
| abstract_inverted_index.egocentric, | 180 |
| abstract_inverted_index.hippocampal | 21, 43 |
| abstract_inverted_index.impairment. | 350 |
| abstract_inverted_index.individuals | 105, 319 |
| abstract_inverted_index.navigation, | 79 |
| abstract_inverted_index.nondemented | 24 |
| abstract_inverted_index.performance | 228, 245 |
| abstract_inverted_index.progression | 346 |
| abstract_inverted_index.significant | 238 |
| abstract_inverted_index.susceptible | 330 |
| abstract_inverted_index.ɛ4–/BDNF | 231 |
| abstract_inverted_index.(p>0.05). | 277 |
| abstract_inverted_index.(p<0.05). | 234 |
| abstract_inverted_index.allocentric, | 181 |
| abstract_inverted_index.established. | 61 |
| abstract_inverted_index.examination, | 172 |
| abstract_inverted_index.hippocampus, | 94 |
| abstract_inverted_index.neurotrophic | 29 |
| abstract_inverted_index.participants | 168 |
| abstract_inverted_index.particularly | 329 |
| abstract_inverted_index.performance, | 243 |
| abstract_inverted_index.polymorphism | 208, 275 |
| abstract_inverted_index.real‐space | 188 |
| abstract_inverted_index.visuospatial | 261 |
| abstract_inverted_index.comprehensive | 170 |
| abstract_inverted_index.polymorphisms | 76, 134, 327 |
| abstract_inverted_index.ɛ4‐related | 54 |
| abstract_inverted_index.apolipoprotein | 3 |
| abstract_inverted_index.brain‐derived | 28 |
| abstract_inverted_index.neuropsychological | 171 |
| abstract_inverted_index.hippocampus‐dependent | 332 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5082174276 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I21250087, https://openalex.org/I4210102302, https://openalex.org/I4210136987 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.18924596 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |