Impact of Completeness of Revascularization on Long-Term Outcomes in Patients With Post-Infarction Ventricular Septal Rupture Article Swipe
Jiexu Ma
,
Hang Xu
,
Shanshan Zheng
,
Zhiyuan Zhu
,
Sheng Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31083/rcm27049
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31083/rcm27049
Background: Ventricular septal rupture (VSR) is a life-threatening complication of myocardial infarction. While surgical repair is regarded as the definitive treatment, the optimal approach to revascularization remains uncertain. This study aims to evaluate the effects of infarct-related artery (IRA) revascularization and the completeness of revascularization on long-term survival and the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) in patients with VSR. Methods: This retrospective study analyzed 132 VSR patients who underwent surgical repair at the Fuwai Hospital from 2004 to 2022. Patients were categorized based on whether they received IRA revascularization. For those with multi-vessel disease (MVD), revascularization was classified as complete or incomplete. The primary outcome was all-cause mortality, with a mean follow-up of 77.8 months (median 71.0 months). The secondary outcome was MACCE. Results: Of the 132 patients, 28 did not undergo IRA revascularization. Kaplan-Meier analysis showed similar all-cause mortality and MACCE rates between patients with and without IRA revascularization. Adjusted Cox regression confirmed no significant association between IRA revascularization and long-term mortality (adjusted hazard ratio [aHR], 0.62; 95% CI: 0.22–1.79) or MACCE (aHR, 1.30; 95% CI: 0.52–3.27). These findings were consistent across both single-vessel and MVD patients. Among the 84 MVD patients, 53 underwent complete revascularization. Patients with complete revascularization had a lower incidence of MACCE (aHR, 0.26; 95% CI: 0.10–0.67) compared to those with incomplete revascularization, although no significant difference in mortality was observed (aHR, 0.57; 95% CI: 0.17–1.85). Conclusions: IRA revascularization does not affect long-term survival or MACCE rates in VSR patients. However, complete revascularization significantly reduces the risk of MACCE in patients with MVD.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31083/rcm27049
- https://www.imrpress.com/journal/RCM/26/6/10.31083/RCM27049/pdf
- OA Status
- gold
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411969732
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411969732Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31083/rcm27049Digital Object Identifier
- Title
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Impact of Completeness of Revascularization on Long-Term Outcomes in Patients With Post-Infarction Ventricular Septal RuptureWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-16Full publication date if available
- Authors
-
Jiexu Ma, Hang Xu, Shanshan Zheng, Zhiyuan Zhu, Sheng LiuList of authors in order
- Landing page
-
https://doi.org/10.31083/rcm27049Publisher landing page
- PDF URL
-
https://www.imrpress.com/journal/RCM/26/6/10.31083/RCM27049/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.imrpress.com/journal/RCM/26/6/10.31083/RCM27049/pdfDirect OA link when available
- Concepts
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Medicine, Revascularization, Hazard ratio, Internal medicine, Cardiology, Myocardial infarction, Proportional hazards model, Retrospective cohort study, Surgery, Incidence (geometry), Coronary artery disease, Confidence interval, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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