Impact of depersonalization on the course of depression: longitudinal observations from the gutenberg health study Article Swipe
Matthias Michal
,
Jörg Wiltink
,
Ana N. Tibubos
,
Philipp S. Wild
,
Thomas Münzel
,
Karl J. Lackner
,
Norbert Pfeiffer
,
J. König
,
Alexander Gieswinkel
,
Manfred E. Beutel
,
Jasmin Ghaemi Kerahrodi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s12888-024-05658-7
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s12888-024-05658-7
Background Symptoms of depersonalization (DP) and derealization (DR) are a risk factor for more severe impairment, non-response to various treatments, and a chronic course. In this study, we investigated the effects of DP/DR symptoms in patients with clinically significant depressive symptoms on clinical characteristics and various outcomes in a representative population-based sample with a 5-year follow-up. Methods The middle-aged sample comprised n = 10,422 persons at baseline, of whom n = 9,301 were free from depressive and DP/DR symptoms. N = 522 persons had clinically significant depression (PHQ-9 ≥ 10) and co-occurring DP/DR symptoms, and n = 599 persons had clinically significant depression (PHQ-9 ≥ 10) without DP/DR symptoms. Results There were substantial health disparities between persons with and without depression. These disparities concerned a wide range of life domains, including lower quality of the recalled early life experiences with the parents, current socioeconomic status, social integration (partnership, loneliness), current social and interpersonal stressors (family, work), functional bodily complaints (e.g., tinnitus, migraine, chest pain), unhealthy lifestyle, and the prevalence of already developed physical diseases. These disparities persisted to the 5-year follow-up and were exceptionally severe for depressed persons with co-occurring DP/DR symptoms. Among the depressed persons, the co-occurrence of DP/DR symptoms more than doubled the risk for recurrence or persistence of depression. Only 6.9% of depressed persons with DP/DR symptoms achieved remission at the 5-year follow-up (PHQ-9 < 5). Depression with and without co-occurring DP/DR worsened self-rated physical health significantly. The impact of depression with co-occurring DP/DR on the worsening of the self-rated physical health status was stronger than those of age and major medical diseases (e.g., heart failure). However, only depression without DP/DR was associated with mortality in a hazard regression analysis adjusted for age, sex, and lifestyle. Conclusions The results demonstrated that DP/DR symptoms represent an important and easily assessable prognostic factor for the course of depression and health outcomes. Given the low remission rates for depression in general and depression with DP/DR in particular, efforts should be made to identify and better support this group, which is disadvantaged in many aspects of life.
Related Topics
Concepts
Depression (economics)
Medicine
Psychiatry
Loneliness
Depersonalization
Patient Health Questionnaire
Population
Clinical psychology
Quality of life (healthcare)
Late life depression
Depressive symptoms
Anxiety
Cognition
Nursing
Economics
Macroeconomics
Emotional exhaustion
Burnout
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12888-024-05658-7
- https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-024-05658-7
- OA Status
- gold
- Cited By
- 4
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392595895
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392595895Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12888-024-05658-7Digital Object Identifier
- Title
-
Impact of depersonalization on the course of depression: longitudinal observations from the gutenberg health studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-08Full publication date if available
- Authors
-
Matthias Michal, Jörg Wiltink, Ana N. Tibubos, Philipp S. Wild, Thomas Münzel, Karl J. Lackner, Norbert Pfeiffer, J. König, Alexander Gieswinkel, Manfred E. Beutel, Jasmin Ghaemi KerahrodiList of authors in order
- Landing page
-
https://doi.org/10.1186/s12888-024-05658-7Publisher landing page
- PDF URL
-
https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-024-05658-7Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-024-05658-7Direct OA link when available
- Concepts
-
Depression (economics), Medicine, Psychiatry, Loneliness, Depersonalization, Patient Health Questionnaire, Population, Clinical psychology, Quality of life (healthcare), Late life depression, Depressive symptoms, Anxiety, Cognition, Nursing, Economics, Macroeconomics, Emotional exhaustion, Burnout, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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