Impact of Doxycycline on COVID-19 Patients with Risk Factors: DYNAMIC, a Multi-Centre, Randomised, Placebo-Controlled, Double-Blind Trial Article Swipe
Alexandra Poinas
,
David Boutoille
,
Florence Vrignaud
,
Jean‐Michel Nguyen
,
Fabrice Bonnet
,
Cédric Rat
,
Gilles Garcia
,
A. Dompmartin
,
M.‐T. Leccia
,
Lionel Piroth
,
E. Maubec
,
Pierre Gandon
,
Alexandra Jobert
,
Soizic Boinet
,
Julie Cassecuel
,
Laurent Flet
,
Amir Khammari
,
Brigitte Dréno
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-29729/v3
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-29729/v3
Background : The DYNAMIC study is based on three properties of tetracyclines. (1) Tetracyclines are known to chelate zinc from matrix metalloproteinases. It is possible their chelating activity may help inhibit COVID-19 infection by limiting its ability to replicate in the host. (2) As seen with dengue virus, tetracyclines may also be able to inhibit the replication of positive polarity single-stranded RNA viruses, such as COVID-19. (3) Tetracyclines are also modulators of innate immunity (anti-inflammatory activity), a property that has been used to treat inflammatory skin diseases for many years. They could therefore participate in limiting the cytokine storm induced by COVID-19. Moreover, the lipophilic nature of tetracyclines and their strong pulmonary penetration could allow them to inhibit viral replication at this level. Among the tetracyclines, doxycycline has three advantages: its long safety history (side effects are uncommon with no notable risks), its short treatment duration and its low cost. Methods : The trial will involve 330 patients who are positive for SARS-CoV-2 infection and have one or more risk factors for worsening the disease. These patients will be included as outpatients for early treatment of illness. For logistical reasons and in order to be able to standardise the study as much as possible, recruitment will take place in 6 hospital departments covering the whole of France. For 14 days they will be given either 200mg of doxycycline a day or placebo. Our hypothesis is a considerable reduction in the number of patients hospitalised due to COVID-19 thanks to the treatment of doxycycline. Discussion : This study could have an impact on the overcrowding of patients with COVID-19 at the hospital which is one of the major world-wide problems of this pandemic. This treatment would therefore contribute to supporting the deconfinement strategy by blocking the viral infection early and reducing the infectious period. Trial Registration : On ClinicalTrials.gov, registration number NCT04371952, first published on 30 April 2020.
Related Topics
Concepts
Doxycycline
Coronavirus disease 2019 (COVID-19)
Medicine
Placebo
Double blind
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Internal medicine
Randomized controlled trial
Alternative medicine
Pathology
Biology
Disease
Antibiotics
Infectious disease (medical specialty)
Microbiology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-29729/v3
- OA Status
- green
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4240938905
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4240938905Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-29729/v3Digital Object Identifier
- Title
-
Impact of Doxycycline on COVID-19 Patients with Risk Factors: DYNAMIC, a Multi-Centre, Randomised, Placebo-Controlled, Double-Blind TrialWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-09Full publication date if available
- Authors
-
Alexandra Poinas, David Boutoille, Florence Vrignaud, Jean‐Michel Nguyen, Fabrice Bonnet, Cédric Rat, Gilles Garcia, A. Dompmartin, M.‐T. Leccia, Lionel Piroth, E. Maubec, Pierre Gandon, Alexandra Jobert, Soizic Boinet, Julie Cassecuel, Laurent Flet, Amir Khammari, Brigitte DrénoList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-29729/v3Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.21203/rs.3.rs-29729/v3Direct OA link when available
- Concepts
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Doxycycline, Coronavirus disease 2019 (COVID-19), Medicine, Placebo, Double blind, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Internal medicine, Randomized controlled trial, Alternative medicine, Pathology, Biology, Disease, Antibiotics, Infectious disease (medical specialty), MicrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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