Impact of Epigenome-Wide Methylation and Breast Cancer Recurrence in Women Tested Negative for BRCA Genes: The Breast Methylation Risk (BREMERI) Study Article Swipe
Silvia Polidoro
,
Harriet Johansson
,
Giovanni Cugliari
,
Aliana Guerrieri‐Gonzaga
,
Valentina Aristarco
,
Debora Macis
,
Mariarosaria Calvello
,
Monica Marabelli
,
Irène Feroce
,
Davide Serrano
,
Sara Cagnacci
,
Cristina Zanzottera
,
Francesca Fava
,
Federica Bellerba
,
Bernardo Bonanni
,
Sara Gandini
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17193132
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17193132
Background and Aim: DNA methylation may contribute to a worsening in breast cancer (BC). Methods: We conducted a matched case–control study to investigate the contribution of DNA methylation (DNAm) in breast cancer recurrence risk. Genome-wide DNAm profiles were generated from peripheral white blood cells (WBC) collected post-surgery from women with primary breast cancer BRCA wild-type, using Illumina Infinium HumanMethylationEPIC array. Cases had to experience recurrence of breast cancer or death and were matched to controls (subjects without recurrence, ratio 1:2) by age at diagnosis (+/− 5 years) and follow-up duration. Results: We identified three differentially methylated regions between the groups. Cases showed two hypomethylated regions, one upstream of the vtRNA2–1 gene (estimate −0.30, p-value < 0.005), and one in the 5′ UTR region of the FGFR2 gene (estimate −0.34, p-value < 0.028), whereas one, upstream of the RUFY1 gene (estimate 0.32, p-value < 0.015), was hypermethylated. Additionally, we identified two methylation signals, recognised as predictors of biochemical traits. The chemokine ligand 21 (unadjusted p-value < 0.03) and insulin receptor expression (unadjusted p-value < 0.04) were higher in cases than in controls. Conclusions: Our exploratory study suggests that specific DNA methylation patterns in WBCs, particularly in genes related to cellular proliferation, invasion, and glucose homeostasis, may be associated with the risk of breast cancer recurrence in BRCA wild-type women. If validated in larger cohorts, these circulating signatures may serve as blood-based biomarkers to improve risk stratification and guide tailored treatment strategies.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers17193132
- https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778
- OA Status
- gold
- References
- 43
- OpenAlex ID
- https://openalex.org/W4414545387
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4414545387Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers17193132Digital Object Identifier
- Title
-
Impact of Epigenome-Wide Methylation and Breast Cancer Recurrence in Women Tested Negative for BRCA Genes: The Breast Methylation Risk (BREMERI) StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-26Full publication date if available
- Authors
-
Silvia Polidoro, Harriet Johansson, Giovanni Cugliari, Aliana Guerrieri‐Gonzaga, Valentina Aristarco, Debora Macis, Mariarosaria Calvello, Monica Marabelli, Irène Feroce, Davide Serrano, Sara Cagnacci, Cristina Zanzottera, Francesca Fava, Federica Bellerba, Bernardo Bonanni, Sara GandiniList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers17193132Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
43Number of works referenced by this work
Full payload
| id | https://openalex.org/W4414545387 |
|---|---|
| doi | https://doi.org/10.3390/cancers17193132 |
| ids.doi | https://doi.org/10.3390/cancers17193132 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41097660 |
| ids.openalex | https://openalex.org/W4414545387 |
| fwci | 0.0 |
| type | article |
| title | Impact of Epigenome-Wide Methylation and Breast Cancer Recurrence in Women Tested Negative for BRCA Genes: The Breast Methylation Risk (BREMERI) Study |
| biblio.issue | 19 |
| biblio.volume | 17 |
| biblio.last_page | 3132 |
| biblio.first_page | 3132 |
| topics[0].id | https://openalex.org/T10269 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Epigenetics and DNA Methylation |
| topics[1].id | https://openalex.org/T11928 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9884999990463257 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1311 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Genetic Syndromes and Imprinting |
| topics[2].id | https://openalex.org/T11482 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.987500011920929 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | RNA modifications and cancer |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| language | en |
| locations[0].id | doi:10.3390/cancers17193132 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S168415115 |
| locations[0].source.issn | 2072-6694 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6694 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancers |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancers |
| locations[0].landing_page_url | https://doi.org/10.3390/cancers17193132 |
| locations[1].id | pmid:41097660 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancers |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41097660 |
| locations[2].id | pmh:oai:europepmc.org:11335963 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12524240 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5044678325 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2968-0575 |
| authorships[0].author.display_name | Silvia Polidoro |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I123338534 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I123338534 |
| authorships[0].institutions[0].ror | https://ror.org/04387x656 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I123338534 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Università degli Studi del Piemonte Orientale “Amedeo Avogadro” |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Silvia Polidoro |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy |
| authorships[1].author.id | https://openalex.org/A5055344568 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4131-2030 |
| authorships[1].author.display_name | Harriet Johansson |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I6141010 |
| authorships[1].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | European Institute of Oncology |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Harriet Johansson |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[2].author.id | https://openalex.org/A5073806582 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6080-0718 |
| authorships[2].author.display_name | Giovanni Cugliari |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I55143463 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Medical Sciences, University of Turin, 10124 Turin, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I55143463 |
| authorships[2].institutions[0].ror | https://ror.org/048tbm396 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I55143463 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Turin |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Giovanni Cugliari |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medical Sciences, University of Turin, 10124 Turin, Italy |
| authorships[3].author.id | https://openalex.org/A5062416354 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1915-1688 |
| authorships[3].author.display_name | Aliana Guerrieri‐Gonzaga |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I6141010 |
| authorships[3].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | European Institute of Oncology |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Aliana Guerrieri-Gonzaga |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[4].author.id | https://openalex.org/A5050159020 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4939-6240 |
| authorships[4].author.display_name | Valentina Aristarco |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I6141010 |
| authorships[4].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | European Institute of Oncology |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Valentina Aristarco |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[5].author.id | https://openalex.org/A5004162486 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0633-2933 |
| authorships[5].author.display_name | Debora Macis |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I6141010 |
| authorships[5].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | European Institute of Oncology |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Debora Macis |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[6].author.id | https://openalex.org/A5010443092 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2113-8503 |
| authorships[6].author.display_name | Mariarosaria Calvello |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I6141010 |
| authorships[6].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | European Institute of Oncology |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mariarosaria Calvello |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[7].author.id | https://openalex.org/A5005064703 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4216-230X |
| authorships[7].author.display_name | Monica Marabelli |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I6141010 |
| authorships[7].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | European Institute of Oncology |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Monica Marabelli |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[8].author.id | https://openalex.org/A5046869628 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9312-2020 |
| authorships[8].author.display_name | Irène Feroce |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I6141010 |
| authorships[8].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | European Institute of Oncology |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Irene Feroce |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[9].author.id | https://openalex.org/A5019084193 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-2945-4108 |
| authorships[9].author.display_name | Davide Serrano |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I6141010 |
| authorships[9].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | European Institute of Oncology |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Davide Serrano |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[10].author.id | https://openalex.org/A5027589608 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-1721-8332 |
| authorships[10].author.display_name | Sara Cagnacci |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[10].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I6141010 |
| authorships[10].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | European Institute of Oncology |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Sara Cagnacci |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[11].author.id | https://openalex.org/A5055860665 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Cristina Zanzottera |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[11].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[11].institutions[0].id | https://openalex.org/I6141010 |
| authorships[11].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | European Institute of Oncology |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Cristina Zanzottera |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[12].author.id | https://openalex.org/A5023559015 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-4363-2353 |
| authorships[12].author.display_name | Francesca Fava |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[12].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[12].institutions[0].id | https://openalex.org/I6141010 |
| authorships[12].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | European Institute of Oncology |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Francesca Fava |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[13].author.id | https://openalex.org/A5035069427 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-5956-4340 |
| authorships[13].author.display_name | Federica Bellerba |
| authorships[13].countries | IT |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Experimental Oncology, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[13].institutions[0].id | https://openalex.org/I6141010 |
| authorships[13].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[13].institutions[0].country_code | IT |
| authorships[13].institutions[0].display_name | European Institute of Oncology |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Federica Bellerba |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Experimental Oncology, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[14].author.id | https://openalex.org/A5079114893 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-3589-2128 |
| authorships[14].author.display_name | Bernardo Bonanni |
| authorships[14].countries | IT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[14].affiliations[0].raw_affiliation_string | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[14].institutions[0].id | https://openalex.org/I6141010 |
| authorships[14].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[14].institutions[0].country_code | IT |
| authorships[14].institutions[0].display_name | European Institute of Oncology |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Bernardo Bonanni |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Division of Cancer Prevention and Genetics, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[15].author.id | https://openalex.org/A5015077519 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-1348-4548 |
| authorships[15].author.display_name | Sara Gandini |
| authorships[15].countries | IT |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I6141010 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Experimental Oncology, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| authorships[15].institutions[0].id | https://openalex.org/I6141010 |
| authorships[15].institutions[0].ror | https://ror.org/02vr0ne26 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210153126, https://openalex.org/I6141010 |
| authorships[15].institutions[0].country_code | IT |
| authorships[15].institutions[0].display_name | European Institute of Oncology |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Sara Gandini |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Experimental Oncology, European Institute of Oncology, IEO, IRRCCS, 20141 Milan, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Impact of Epigenome-Wide Methylation and Breast Cancer Recurrence in Women Tested Negative for BRCA Genes: The Breast Methylation Risk (BREMERI) Study |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10269 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Epigenetics and DNA Methylation |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/cancers17193132 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S168415115 |
| best_oa_location.source.issn | 2072-6694 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6694 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancers |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancers |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cancers17193132 |
| primary_location.id | doi:10.3390/cancers17193132 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S168415115 |
| primary_location.source.issn | 2072-6694 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6694 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancers |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2072-6694/17/19/3132/pdf?version=1758882778 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancers |
| primary_location.landing_page_url | https://doi.org/10.3390/cancers17193132 |
| publication_date | 2025-09-26 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3140415241, https://openalex.org/W3082133711, https://openalex.org/W2793868488, https://openalex.org/W2939678336, https://openalex.org/W2026111133, https://openalex.org/W1849862482, https://openalex.org/W2748237445, https://openalex.org/W3003574261, https://openalex.org/W4412535612, https://openalex.org/W2151420891, https://openalex.org/W4400612582, https://openalex.org/W3209096298, https://openalex.org/W4391451393, https://openalex.org/W4385631859, https://openalex.org/W2529024004, https://openalex.org/W2136895197, https://openalex.org/W2169556367, https://openalex.org/W3112474449, https://openalex.org/W4393153679, https://openalex.org/W2902374889, https://openalex.org/W4302287595, https://openalex.org/W3183340488, https://openalex.org/W4406264364, https://openalex.org/W3214542861, https://openalex.org/W4376138899, https://openalex.org/W4310211232, https://openalex.org/W3216817730, https://openalex.org/W4403252601, https://openalex.org/W4281763897, https://openalex.org/W4360604204, https://openalex.org/W3119446498, https://openalex.org/W3048608799, https://openalex.org/W2085701948, https://openalex.org/W3153745588, https://openalex.org/W4385813796, https://openalex.org/W3093303864, https://openalex.org/W1989893389, https://openalex.org/W4307771966, https://openalex.org/W3159950454, https://openalex.org/W2156487555, https://openalex.org/W3020088622, https://openalex.org/W1984532045, https://openalex.org/W4282971486 |
| referenced_works_count | 43 |
| abstract_inverted_index.5 | 85 |
| abstract_inverted_index.a | 8, 17 |
| abstract_inverted_index.21 | 161 |
| abstract_inverted_index.If | 218 |
| abstract_inverted_index.We | 15, 91 |
| abstract_inverted_index.as | 153, 228 |
| abstract_inverted_index.at | 82 |
| abstract_inverted_index.be | 205 |
| abstract_inverted_index.by | 80 |
| abstract_inverted_index.in | 10, 29, 118, 176, 179, 191, 194, 214, 220 |
| abstract_inverted_index.of | 25, 65, 107, 123, 135, 155, 210 |
| abstract_inverted_index.or | 68 |
| abstract_inverted_index.to | 7, 21, 62, 73, 197, 231 |
| abstract_inverted_index.we | 147 |
| abstract_inverted_index.DNA | 3, 26, 188 |
| abstract_inverted_index.Our | 182 |
| abstract_inverted_index.The | 158 |
| abstract_inverted_index.UTR | 121 |
| abstract_inverted_index.age | 81 |
| abstract_inverted_index.and | 1, 70, 87, 116, 166, 201, 235 |
| abstract_inverted_index.had | 61 |
| abstract_inverted_index.may | 5, 204, 226 |
| abstract_inverted_index.one | 105, 117 |
| abstract_inverted_index.the | 23, 98, 108, 119, 124, 136, 208 |
| abstract_inverted_index.two | 102, 149 |
| abstract_inverted_index.was | 144 |
| abstract_inverted_index.< | 114, 130, 142, 164, 172 |
| abstract_inverted_index.1:2) | 79 |
| abstract_inverted_index.5′ | 120 |
| abstract_inverted_index.Aim: | 2 |
| abstract_inverted_index.BRCA | 53, 215 |
| abstract_inverted_index.DNAm | 35 |
| abstract_inverted_index.from | 39, 47 |
| abstract_inverted_index.gene | 110, 126, 138 |
| abstract_inverted_index.one, | 133 |
| abstract_inverted_index.risk | 209, 233 |
| abstract_inverted_index.than | 178 |
| abstract_inverted_index.that | 186 |
| abstract_inverted_index.were | 37, 71, 174 |
| abstract_inverted_index.with | 49, 207 |
| abstract_inverted_index.(BC). | 13 |
| abstract_inverted_index.(WBC) | 44 |
| abstract_inverted_index.0.03) | 165 |
| abstract_inverted_index.0.04) | 173 |
| abstract_inverted_index.0.32, | 140 |
| abstract_inverted_index.Cases | 60, 100 |
| abstract_inverted_index.FGFR2 | 125 |
| abstract_inverted_index.RUFY1 | 137 |
| abstract_inverted_index.WBCs, | 192 |
| abstract_inverted_index.blood | 42 |
| abstract_inverted_index.cases | 177 |
| abstract_inverted_index.cells | 43 |
| abstract_inverted_index.death | 69 |
| abstract_inverted_index.genes | 195 |
| abstract_inverted_index.guide | 236 |
| abstract_inverted_index.ratio | 78 |
| abstract_inverted_index.risk. | 33 |
| abstract_inverted_index.serve | 227 |
| abstract_inverted_index.study | 20, 184 |
| abstract_inverted_index.these | 223 |
| abstract_inverted_index.three | 93 |
| abstract_inverted_index.using | 55 |
| abstract_inverted_index.white | 41 |
| abstract_inverted_index.women | 48 |
| abstract_inverted_index.(+/− | 84 |
| abstract_inverted_index.(DNAm) | 28 |
| abstract_inverted_index.array. | 59 |
| abstract_inverted_index.breast | 11, 30, 51, 66, 211 |
| abstract_inverted_index.cancer | 12, 31, 52, 67, 212 |
| abstract_inverted_index.higher | 175 |
| abstract_inverted_index.larger | 221 |
| abstract_inverted_index.ligand | 160 |
| abstract_inverted_index.region | 122 |
| abstract_inverted_index.showed | 101 |
| abstract_inverted_index.women. | 217 |
| abstract_inverted_index.years) | 86 |
| abstract_inverted_index.0.005), | 115 |
| abstract_inverted_index.0.015), | 143 |
| abstract_inverted_index.0.028), | 131 |
| abstract_inverted_index.between | 97 |
| abstract_inverted_index.glucose | 202 |
| abstract_inverted_index.groups. | 99 |
| abstract_inverted_index.improve | 232 |
| abstract_inverted_index.insulin | 167 |
| abstract_inverted_index.matched | 18, 72 |
| abstract_inverted_index.p-value | 113, 129, 141, 163, 171 |
| abstract_inverted_index.primary | 50 |
| abstract_inverted_index.regions | 96 |
| abstract_inverted_index.related | 196 |
| abstract_inverted_index.traits. | 157 |
| abstract_inverted_index.whereas | 132 |
| abstract_inverted_index.without | 76 |
| abstract_inverted_index.Illumina | 56 |
| abstract_inverted_index.Infinium | 57 |
| abstract_inverted_index.Methods: | 14 |
| abstract_inverted_index.Results: | 90 |
| abstract_inverted_index.cellular | 198 |
| abstract_inverted_index.cohorts, | 222 |
| abstract_inverted_index.controls | 74 |
| abstract_inverted_index.patterns | 190 |
| abstract_inverted_index.profiles | 36 |
| abstract_inverted_index.receptor | 168 |
| abstract_inverted_index.regions, | 104 |
| abstract_inverted_index.signals, | 151 |
| abstract_inverted_index.specific | 187 |
| abstract_inverted_index.suggests | 185 |
| abstract_inverted_index.tailored | 237 |
| abstract_inverted_index.upstream | 106, 134 |
| abstract_inverted_index.−0.30, | 112 |
| abstract_inverted_index.−0.34, | 128 |
| abstract_inverted_index.(estimate | 111, 127, 139 |
| abstract_inverted_index.(subjects | 75 |
| abstract_inverted_index.chemokine | 159 |
| abstract_inverted_index.collected | 45 |
| abstract_inverted_index.conducted | 16 |
| abstract_inverted_index.controls. | 180 |
| abstract_inverted_index.diagnosis | 83 |
| abstract_inverted_index.duration. | 89 |
| abstract_inverted_index.follow-up | 88 |
| abstract_inverted_index.generated | 38 |
| abstract_inverted_index.invasion, | 200 |
| abstract_inverted_index.treatment | 238 |
| abstract_inverted_index.validated | 219 |
| abstract_inverted_index.wild-type | 216 |
| abstract_inverted_index.worsening | 9 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.associated | 206 |
| abstract_inverted_index.biomarkers | 230 |
| abstract_inverted_index.contribute | 6 |
| abstract_inverted_index.experience | 63 |
| abstract_inverted_index.expression | 169 |
| abstract_inverted_index.identified | 92, 148 |
| abstract_inverted_index.methylated | 95 |
| abstract_inverted_index.peripheral | 40 |
| abstract_inverted_index.predictors | 154 |
| abstract_inverted_index.recognised | 152 |
| abstract_inverted_index.recurrence | 32, 64, 213 |
| abstract_inverted_index.signatures | 225 |
| abstract_inverted_index.vtRNA2–1 | 109 |
| abstract_inverted_index.wild-type, | 54 |
| abstract_inverted_index.(unadjusted | 162, 170 |
| abstract_inverted_index.Genome-wide | 34 |
| abstract_inverted_index.biochemical | 156 |
| abstract_inverted_index.blood-based | 229 |
| abstract_inverted_index.circulating | 224 |
| abstract_inverted_index.exploratory | 183 |
| abstract_inverted_index.investigate | 22 |
| abstract_inverted_index.methylation | 4, 27, 150, 189 |
| abstract_inverted_index.recurrence, | 77 |
| abstract_inverted_index.strategies. | 239 |
| abstract_inverted_index.Conclusions: | 181 |
| abstract_inverted_index.contribution | 24 |
| abstract_inverted_index.homeostasis, | 203 |
| abstract_inverted_index.particularly | 193 |
| abstract_inverted_index.post-surgery | 46 |
| abstract_inverted_index.Additionally, | 146 |
| abstract_inverted_index.case–control | 19 |
| abstract_inverted_index.differentially | 94 |
| abstract_inverted_index.hypomethylated | 103 |
| abstract_inverted_index.proliferation, | 199 |
| abstract_inverted_index.stratification | 234 |
| abstract_inverted_index.hypermethylated. | 145 |
| abstract_inverted_index.HumanMethylationEPIC | 58 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5055344568 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I6141010 |
| citation_normalized_percentile.value | 0.43168273 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |