Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo Article Swipe
Adriana Renzoni
,
Elodie von Dach
,
Caroline Landelle
,
Seydina M. Diene
,
Caroline Manzano
,
R. Gonzales
,
Wessam Abdelhady
,
Christopher P. Randall
,
Eve-Julie Bonetti
,
Damien Baud
,
Alex J. O’Neill
,
Arnold S. Bayer
,
Abdessalam Cherkaoui
,
Jacques Schrenzel
,
Stephan Harbarth
,
Patrice François
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00272-17
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00272-17
Methicillin-resistant Staphylococcus aureus (MRSA) resistant to decolonization agents such as mupirocin and chlorhexidine increases the need for development of alternative decolonization molecules. The absence of reported severe adverse reactions and bacterial resistance to polyhexanide makes it an excellent choice as a topical antiseptic. In the present study, we evaluated the in vitro and in vivo capacity to generate strains with reduced polyhexanide susceptibility and cross-resistance with chlorhexidine and/or antibiotics currently used in clinic. Here we report the in vitro emergence of reduced susceptibility to polyhexanide by prolonged stepwise exposure to low concentrations in broth culture. Reduced susceptibility to polyhexanide was associated with genomic changes in the mprF and purR genes and with concomitant decreased susceptibility to daptomycin and other cell wall-active antibiotics. However, the in vitro emergence of reduced susceptibility to polyhexanide did not result in cross-resistance to chlorhexidine. During in vivo polyhexanide clinical decolonization treatment, neither reduced polyhexanide susceptibility nor chlorhexidine cross-resistance was observed. Together, these observations suggest that polyhexanide could be used safely for decolonization of carriers of chlorhexidine-resistant S. aureus strains; they also highlight the need for careful use of polyhexanide at low antiseptic concentrations.
Related Topics
Concepts
Antiseptic
Microbiology
Mupirocin
Chlorhexidine
Checkerboard
Staphylococcus aureus
Biology
In vivo
Methicillin-resistant Staphylococcus aureus
Chemistry
Medicine
Bacteria
Genetics
Organic chemistry
Dentistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.00272-17
- https://aac.asm.org/content/aac/61/10/e00272-17.full.pdf
- OA Status
- bronze
- Cited By
- 40
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2744033108
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2744033108Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/aac.00272-17Digital Object Identifier
- Title
-
Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In VivoWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-08-08Full publication date if available
- Authors
-
Adriana Renzoni, Elodie von Dach, Caroline Landelle, Seydina M. Diene, Caroline Manzano, R. Gonzales, Wessam Abdelhady, Christopher P. Randall, Eve-Julie Bonetti, Damien Baud, Alex J. O’Neill, Arnold S. Bayer, Abdessalam Cherkaoui, Jacques Schrenzel, Stephan Harbarth, Patrice FrançoisList of authors in order
- Landing page
-
https://doi.org/10.1128/aac.00272-17Publisher landing page
- PDF URL
-
https://aac.asm.org/content/aac/61/10/e00272-17.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://aac.asm.org/content/aac/61/10/e00272-17.full.pdfDirect OA link when available
- Concepts
-
Antiseptic, Microbiology, Mupirocin, Chlorhexidine, Checkerboard, Staphylococcus aureus, Biology, In vivo, Methicillin-resistant Staphylococcus aureus, Chemistry, Medicine, Bacteria, Genetics, Organic chemistry, DentistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
40Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 9, 2023: 3, 2022: 3, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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