Impact of Hepatitis E Virus Screening in the UK Deceased Organ Donor Population Article Swipe
Ines Ushiro‐Lumb
,
John Forsythe
,
Becky Haywood
,
Christie Geoghegan
,
Victoria Maddox
,
Samreen Ijaz
,
Derek Manas
,
Douglas Thorburn
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/ti.2023.11673
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/ti.2023.11673
Universal Hepatitis E Virus (HEV) screening of deceased organ donors was implemented by the UK national organ procurement organisation in October 2017. Donor testing for HEV infection is done post-transplant; detection of HEV ribonucleic acid (RNA) in donor plasma is therefore not a contra-indication for organ donation, with the result being used to inform recipient management. Immediate post-transplant detection of donor HEV viraemia triggers notification to transplant centres. Follow up of liver and kidney recipients has shown that transmission through solid organs is very efficient, particularly through liver grafts, as expected; no other organ types were transplanted in this cohort. Although donors with higher plasma viral load (VL > 10 3 IU/mL) were invariably associated with recipient infection, transmission was also documented at lower VL levels. Knowledge of donor HEV status has led to identification of transmission of infection via solid organ grafts followed by close patient monitoring and informed clinical management decisions. The purpose of this strategy is to allow early detection of infection and recurrence and treatment to circumvent the risk of accelerated liver damage from chronic HEV infection due to undiagnosed, inadvertent donor-derived transmission of infection.
Related Topics
Concepts
Medicine
Transmission (telecommunications)
Organ donation
Hepatitis E virus
Organ procurement
Viral load
Population
Internal medicine
Solid organ
Cohort
Organ transplantation
Immunology
Virology
Transplantation
Virus
Environmental health
Biology
Genotype
Gene
Engineering
Biochemistry
Electrical engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/ti.2023.11673
- https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11673/pdf
- OA Status
- gold
- Cited By
- 12
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386418892
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386418892Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/ti.2023.11673Digital Object Identifier
- Title
-
Impact of Hepatitis E Virus Screening in the UK Deceased Organ Donor PopulationWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-04Full publication date if available
- Authors
-
Ines Ushiro‐Lumb, John Forsythe, Becky Haywood, Christie Geoghegan, Victoria Maddox, Samreen Ijaz, Derek Manas, Douglas ThorburnList of authors in order
- Landing page
-
https://doi.org/10.3389/ti.2023.11673Publisher landing page
- PDF URL
-
https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11673/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11673/pdfDirect OA link when available
- Concepts
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Medicine, Transmission (telecommunications), Organ donation, Hepatitis E virus, Organ procurement, Viral load, Population, Internal medicine, Solid organ, Cohort, Organ transplantation, Immunology, Virology, Transplantation, Virus, Environmental health, Biology, Genotype, Gene, Engineering, Biochemistry, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 11Per-year citation counts (last 5 years)
- References (count)
-
9Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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