Impact of HLA class I functional divergence on HIV control Article Swipe
Mathias Viard
,
Colm Ó’hUigín
,
Yuko Yuki
,
Arman Bashirova
,
David R. Collins
,
Jonathan M. Urbach
,
Steven M. Wolinsky
,
Susan Buchbinder
,
Gregory D. Kirk
,
James J. Goedert
,
Nelson L. Michael
,
David W. Haas
,
Steven G. Deeks
,
Bruce D. Walker
,
Xu G. Yu
,
Mary Carrington
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1126/science.adk0777
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1126/science.adk0777
Heterozygosity of Human leukocyte antigen ( HLA ) class I genes is linked to beneficial outcomes after HIV infection, presumably through greater breadth of HIV epitope presentation and cytotoxic T cell response. Distinct allotype pairs, however, differ in the extent to which they bind shared sets of peptides. We developed a functional divergence metric that measures pairwise complementarity of allotype-associated peptide binding profiles. Greater functional divergence for pairs of HLA-A and/or HLA-B allotypes was associated with slower AIDS progression and independently with enhanced viral load control. The metric predicts immune breadth at the peptide level rather than gene level and redefines HLA heterozygosity as a continuum differentially affecting disease outcome. Functional divergence may affect response to additional infections, vaccination, immunotherapy, and other diseases where HLA heterozygote advantage occurs.
Related Topics
Concepts
Allotype
Human leukocyte antigen
Loss of heterozygosity
Biology
Immunology
Major histocompatibility complex
Immune system
Genetics
HLA-B Antigens
Gene
Antigen
Allele
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/science.adk0777
- OA Status
- gold
- Cited By
- 8
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390967605
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390967605Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1126/science.adk0777Digital Object Identifier
- Title
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Impact of HLA class I functional divergence on HIV controlWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-18Full publication date if available
- Authors
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Mathias Viard, Colm Ó’hUigín, Yuko Yuki, Arman Bashirova, David R. Collins, Jonathan M. Urbach, Steven M. Wolinsky, Susan Buchbinder, Gregory D. Kirk, James J. Goedert, Nelson L. Michael, David W. Haas, Steven G. Deeks, Bruce D. Walker, Xu G. Yu, Mary CarringtonList of authors in order
- Landing page
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https://doi.org/10.1126/science.adk0777Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://escholarship.org/content/qt4tn1x46s/qt4tn1x46s.pdfDirect OA link when available
- Concepts
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Allotype, Human leukocyte antigen, Loss of heterozygosity, Biology, Immunology, Major histocompatibility complex, Immune system, Genetics, HLA-B Antigens, Gene, Antigen, AlleleTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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2025: 4, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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