Impact of increased diagnosis of early HIV infection and immediate antiretroviral treatment initiation on HIV transmission among men who have sex with men in the Netherlands Article Swipe
Alexandra Teslya
,
Janneke C. M. Heijne
,
Maarten F. Schim van der Loeff
,
Ard van Sighem
,
Jacob Aiden Roberts
,
Maartje Dijkstra
,
Godelieve J. de Bree
,
Axel J. Schmidt
,
Kai J. Jonas
,
Mirjam Kretzschmar
,
Ganna Rozhnova
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1012055
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1012055
The number of new HIV infections among men who have sex with men (MSM) in the Netherlands has been decreasing, but additional efforts are required to bring it further down. This study aims to assess the impact of increased diagnosis of early HIV infection combined with immediate antiretroviral treatment (ART) initiation on reducing HIV transmission among MSM. We developed an agent-based model calibrated to HIV surveillance and sexual behavior data for MSM in the Netherlands in 2017-2022. Starting in 2023, we simulated a 10-year intervention that accelerates HIV diagnosis during the first 3 or 6 months after HIV acquisition across five levels of increased diagnosis rates (2, 4, 8, 16, and 32-fold), followed by immediate ART initiation. The upper limit of the intervention’s impact over 10 years is projected to result in the cumulative 298 (95-th QI: 162–451) HIV infections averted. A 32-fold increase in the diagnosis rate within 3 months after HIV acquisition (corresponding to 100% of all new HIV infections diagnosed within 3 months of acquisition) results in 269 (95-th QI: 147–400) infections averted, approaching closely maximum impact. By extending the scope of the intervention to individuals who acquired HIV infection within the previous 6 months, a smaller 8-fold increase in the diagnosis rate (corresponding to 97% of new HIV infections diagnosed within 6 months of acquisition) approaches closely the maximum impact of the intervention by averting 256 (95-th QI: 122–411) HIV infections. Our sensitivity analyses showed that, in an epidemiological context similar to the modern-day the Netherlands, immediate initiation of ART accompanying accelerated diagnosis of individuals with early HIV infection does not significantly affect HIV transmission dynamics. Accelerating early HIV diagnosis through increased awareness, screening, and testing can further reduce transmission among MSM. Meeting this goal necessitates a stakeholder needs assessment.
Related Topics
Concepts
Human immunodeficiency virus (HIV)
Antiretroviral treatment
Transmission (telecommunications)
Medicine
Antiretroviral therapy
Men who have sex with men
Virology
Lentivirus
Immunology
Viral load
Viral disease
Syphilis
Engineering
Electrical engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pcbi.1012055
- https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012055&type=printable
- OA Status
- gold
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408025849
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408025849Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pcbi.1012055Digital Object Identifier
- Title
-
Impact of increased diagnosis of early HIV infection and immediate antiretroviral treatment initiation on HIV transmission among men who have sex with men in the NetherlandsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-27Full publication date if available
- Authors
-
Alexandra Teslya, Janneke C. M. Heijne, Maarten F. Schim van der Loeff, Ard van Sighem, Jacob Aiden Roberts, Maartje Dijkstra, Godelieve J. de Bree, Axel J. Schmidt, Kai J. Jonas, Mirjam Kretzschmar, Ganna RozhnovaList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pcbi.1012055Publisher landing page
- PDF URL
-
https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012055&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012055&type=printableDirect OA link when available
- Concepts
-
Human immunodeficiency virus (HIV), Antiretroviral treatment, Transmission (telecommunications), Medicine, Antiretroviral therapy, Men who have sex with men, Virology, Lentivirus, Immunology, Viral load, Viral disease, Syphilis, Engineering, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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