Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies Article Swipe

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Emina Jukic , Michael Blatzer , Ulrike Binder , Lisa Mayr , Cornelia Lass‐Flörl , Michaela Lackner ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1128/aac.00755-17

Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result from increased growth rates at drug-free conditions. We evaluated the differences in AMB susceptibility and virulence between sector subcultures (ATSec), AMB-resistant (ATR) strains, and AMB-susceptible (ATS) strains. By comparing A. terreus AMB-resistant (ATR) strains and A. terreus sector (ATSec) cultures we observed a highly significant reduction of AMB MICs in ATSec (ATR MIC, 2 to 32 μg/ml; ATSec MIC, 0.12 to 5 μg/ml). Furthermore, Galleria mellonella survival studies revealed an enhanced virulence of ATSec, which was comparable with that of AMB-sensitive Aspergillus terreus strains (median survival rates for ATS isolates, 72 h; for ATSec isolate ATSec G1 , 84 h; for ATR isolates, 144 h). Our findings clearly demonstrate that spontaneous culture degeneration occurs in A. terreus and, most importantly, crucially impacts drug efficacy and virulence.

Related Topics

Virulence

Biology

Antifungal

Concepts

Aspergillus terreus Virulence Galleria mellonella Amphotericin B Microbiology Biology Antifungal drug Fungi imperfecti Antifungal Genetics Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.1128/aac.00755-17
PDF: https://aac.asm.org/content/aac/61/12/e00755-17.full.pdf
OA Status: bronze
Cited By: 9
References: 19
Related Works: 10
OpenAlex ID: https://openalex.org/W2761258860

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OpenAlex ID: https://openalex.org/W2761258860

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DOI: https://doi.org/10.1128/aac.00755-17

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Title: Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies

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Type: article

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Language: en

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Publication year: 2017

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Publication date: 2017-10-10

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Authors: Emina Jukic, Michael Blatzer, Ulrike Binder, Lisa Mayr, Cornelia Lass‐Flörl, Michaela Lackner

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Landing page: https://doi.org/10.1128/aac.00755-17

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PDF URL: https://aac.asm.org/content/aac/61/12/e00755-17.full.pdf

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OA status: bronze

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Concepts: Aspergillus terreus, Virulence, Galleria mellonella, Amphotericin B, Microbiology, Biology, Antifungal drug, Fungi imperfecti, Antifungal, Genetics, Gene

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Cited by: 9

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References (count): 19

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