Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts Article Swipe
Giuseppina Conteduca
,
Davide Cangelosi
,
Chiara Baldo
,
Alessia Arado
,
Barbara Testa
,
Ryan T. Wagner
,
Keith D. Robertson
,
Samuel Dequiedt
,
Lane Fitzsimmons
,
Michela Malacarne
,
Gilberto Filaci
,
Domenico Coviello
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/genes15091117
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/genes15091117
Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic variants promote neoplastic cell transformation. Our previous studies revealed three alternative RNA isoforms of NSD1 present in fibroblast cell lines (FBs): the canonical full transcript and 2 alternative transcripts, termed AT2 (NSD1 Δ5Δ7) and AT3 (NSD1 Δ19–23 at the 5′ end). The precise molecular pathways affected by each specific isoform of NSD1 are uncharacterized to date. To elucidate the role of these isoforms, their expression was suppressed by siRNA knockdown in FBs and protein expression and transcriptome data was explored. We demonstrate that one gene target of NSD1 isoform AT2 is ARP3 actin-related protein 3 homolog B (ACTR3B). We show that loss of both canonical NSD1 and AT2 isoforms impaired the ability of fibroblasts to regulate the actin cytoskeleton, and we observed that this caused selective loss of stress fibers. Our findings provide novel insights into NSD1 function by distinguishing isoform function and demonstrating an essential role of NSD1 in regulating the actin cytoskeleton and stress fiber formation in fibroblasts.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/genes15091117
- https://www.mdpi.com/2073-4425/15/9/1117/pdf?version=1724491540
- OA Status
- gold
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401893424
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401893424Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/genes15091117Digital Object Identifier
- Title
-
Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in FibroblastsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-24Full publication date if available
- Authors
-
Giuseppina Conteduca, Davide Cangelosi, Chiara Baldo, Alessia Arado, Barbara Testa, Ryan T. Wagner, Keith D. Robertson, Samuel Dequiedt, Lane Fitzsimmons, Michela Malacarne, Gilberto Filaci, Domenico CovielloList of authors in order
- Landing page
-
https://doi.org/10.3390/genes15091117Publisher landing page
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https://www.mdpi.com/2073-4425/15/9/1117/pdf?version=1724491540Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4425/15/9/1117/pdf?version=1724491540Direct OA link when available
- Concepts
-
Actin, Somatic cell, Transformation (genetics), Biology, Gene, Gene isoform, Genetics, Germline, Cell division, Cell biology, CellTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
57Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-08-24 |
| publication_year | 2024 |
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