Impact of persistent PSA after salvage radical prostatectomy: a multicenter study Article Swipe
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· 2023
· Open Access
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· DOI: https://doi.org/10.1038/s41391-023-00728-5
Background and objective Persistent prostatic specific antigen (PSA) represents a poor prognostic factor for recurrence after radical prostatectomy (RP). However, the impact of persistent PSA on oncologic outcomes in patients undergoing salvage RP is unknown. To investigate the impact of persistent PSA after salvage RP on long-term oncologic outcomes. Material and methods Patients who underwent salvage RP for recurrent prostate cancer between 2000 and 2021 were identified from twelve high-volume centers. Only patients with available PSA after salvage RP were included. Kaplan-Meier analyses and multivariable Cox regression models were used to test the effect of persistent PSA on biochemical recurrence (BCR), metastasis and any death after salvage RP. Persistent PSA was defined as a PSA-value ≥ 0.1 ng/ml, at first PSA-measurement after salvage RP. Results Overall, 580 patients were identified. Of those, 42% (n = 242) harbored persistent PSA. Median follow-up after salvage RP was 38 months, median time to salvage RP was 64 months and median time to first PSA after salvage RP was 2.2 months. At 84 months after salvage RP, BCR-free, metastasis-free, and overall survival was 6.6 vs. 59%, 71 vs. 88% and 77 vs. 94% for patients with persistent vs. undetectable PSA after salvage RP (all p < 0.01). In multivariable Cox models persistent PSA was an independent predictor for BCR (HR: 5.47, p < 0.001) and death (HR: 3.07, p < 0.01). Conclusion Persistent PSA is common after salvage RP and represents an independent predictor for worse oncologic outcomes. Patients undergoing salvage RP should be closely monitored after surgery to identify those with persistent PSA.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41391-023-00728-5
- https://www.nature.com/articles/s41391-023-00728-5.pdf
- OA Status
- hybrid
- Cited By
- 9
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387406131
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387406131Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41391-023-00728-5Digital Object Identifier
- Title
-
Impact of persistent PSA after salvage radical prostatectomy: a multicenter studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-06Full publication date if available
- Authors
-
Felix Preißer, Reha‐Baris Incesu, Paweł Rajwa, Marcin Chłosta, Florian Nohe, Mohamed Ahmed, Andre Luis Abreu, Giovanni Cacciamani, Luís Ribeiro, Alexander Kretschmer, Thilo Westhofen, Joseph A. Smith, Thomas Steuber, Giorgio Calleris, Yannic Raskin, Paolo Gontero, Steven Joniau, Rafael Sánchez-Salas, Shahrokh F. Shariat, Inderbir S. Gill, R. Jeffrey Karnes, Paul Cathcart, Henk G. van der Poel, Giancarlo Marra, Derya TilkiList of authors in order
- Landing page
-
https://doi.org/10.1038/s41391-023-00728-5Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41391-023-00728-5.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41391-023-00728-5.pdfDirect OA link when available
- Concepts
-
Medicine, Prostatectomy, Salvage therapy, Prostate cancer, Prostate-specific antigen, Biochemical recurrence, Urology, Proportional hazards model, Surgery, Internal medicine, Cancer, ChemotherapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 4, 2023: 1Per-year citation counts (last 5 years)
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23Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.should | 249 |
| abstract_inverted_index.those, | 132 |
| abstract_inverted_index.twelve | 69 |
| abstract_inverted_index.Results | 125 |
| abstract_inverted_index.antigen | 7 |
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| abstract_inverted_index.closely | 251 |
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| abstract_inverted_index.methods | 52 |
| abstract_inverted_index.months, | 147 |
| abstract_inverted_index.months. | 167 |
| abstract_inverted_index.overall | 177 |
| abstract_inverted_index.radical | 17 |
| abstract_inverted_index.salvage | 32, 44, 56, 78, 107, 123, 143, 151, 163, 172, 198, 234, 247 |
| abstract_inverted_index.surgery | 254 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.Material | 50 |
| abstract_inverted_index.Overall, | 126 |
| abstract_inverted_index.Patients | 53, 245 |
| abstract_inverted_index.analyses | 83 |
| abstract_inverted_index.centers. | 71 |
| abstract_inverted_index.harbored | 137 |
| abstract_inverted_index.identify | 256 |
| abstract_inverted_index.outcomes | 28 |
| abstract_inverted_index.patients | 30, 73, 128, 191 |
| abstract_inverted_index.prostate | 60 |
| abstract_inverted_index.specific | 6 |
| abstract_inverted_index.survival | 178 |
| abstract_inverted_index.unknown. | 35 |
| abstract_inverted_index.BCR-free, | 174 |
| abstract_inverted_index.PSA-value | 115 |
| abstract_inverted_index.available | 75 |
| abstract_inverted_index.follow-up | 141 |
| abstract_inverted_index.included. | 81 |
| abstract_inverted_index.long-term | 47 |
| abstract_inverted_index.monitored | 252 |
| abstract_inverted_index.objective | 3 |
| abstract_inverted_index.oncologic | 27, 48, 243 |
| abstract_inverted_index.outcomes. | 49, 244 |
| abstract_inverted_index.predictor | 213, 240 |
| abstract_inverted_index.prostatic | 5 |
| abstract_inverted_index.recurrent | 59 |
| abstract_inverted_index.underwent | 55 |
| abstract_inverted_index.Background | 1 |
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| abstract_inverted_index.Persistent | 4, 109, 229 |
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| abstract_inverted_index.metastasis | 102 |
| abstract_inverted_index.persistent | 24, 41, 96, 138, 193, 208, 259 |
| abstract_inverted_index.prognostic | 12 |
| abstract_inverted_index.recurrence | 15, 100 |
| abstract_inverted_index.regression | 87 |
| abstract_inverted_index.represents | 9, 237 |
| abstract_inverted_index.undergoing | 31, 246 |
| abstract_inverted_index.biochemical | 99 |
| abstract_inverted_index.high-volume | 70 |
| abstract_inverted_index.identified. | 130 |
| abstract_inverted_index.independent | 212, 239 |
| abstract_inverted_index.investigate | 37 |
| abstract_inverted_index.Kaplan-Meier | 82 |
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| abstract_inverted_index.PSA-measurement | 121 |
| abstract_inverted_index.metastasis-free, | 175 |
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| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5030545703 |
| countries_distinct_count | 9 |
| institutions_distinct_count | 25 |
| corresponding_institution_ids | https://openalex.org/I159176309, https://openalex.org/I4210108711 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.91045523 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |