Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes Article Swipe
Midori Fujishiro
,
Hisamitsu Ishihara
,
Katsuhiko Ogawa
,
Takayo Murase
,
Takashi Nakamura
,
Kentaro Watanabe
,
Hideyuki Sakoda
,
Hiraku Ono
,
Takeshi Yamamotoya
,
Yusuke Nakatsu
,
Tomoichiro Asano
,
Akifumi Kushiyama
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines9081052
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines9081052
To unravel associations between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications, especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a novel assay. Patients with type 2 diabetes mellitus (T2DM) with available nerve conduction study (NCS) data were analyzed. None were currently taking XOR inhibitors. XOR activity of fasting blood samples was assayed using a stable isotope-labeled substrate and LC-TQMS. JMP Clinical version 5.0. was used for analysis. We analyzed 54 patients. Mean age was 64.7 years, mean body mass index was 26.0 kg/m2, and mean glycated hemoglobin was 9.4%. The logarithmically transformed plasma XOR activity (ln-XOR) correlated positively with hypoxanthine, xanthine, visceral fatty area, and liver dysfunction but negatively with HDL cholesterol. ln-XOR correlated negatively with diabetes duration and maximum intima-media thickness. Stepwise multiple regression analysis revealed ln-XOR to be among selected explanatory factors for various NCS parameters. Receiver operating characteristic curves showed the discriminatory power of ln-XOR. Principal component analysis revealed a negative relationship of ln-XOR with F-waves as well as positive relationships of ln-XOR with hepatic steatosis and obesity-related disorders. Taken together, our results show plasma XOR activity to be among potential disease status predictors in T2DM patients. Plasma XOR activity measurements might reliably detect pre-symptomatic DSP.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines9081052
- https://www.mdpi.com/2227-9059/9/8/1052/pdf?version=1629966020
- OA Status
- gold
- Cited By
- 3
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3195255636
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- OpenAlex ID
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https://openalex.org/W3195255636Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines9081052Digital Object Identifier
- Title
-
Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 DiabetesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-19Full publication date if available
- Authors
-
Midori Fujishiro, Hisamitsu Ishihara, Katsuhiko Ogawa, Takayo Murase, Takashi Nakamura, Kentaro Watanabe, Hideyuki Sakoda, Hiraku Ono, Takeshi Yamamotoya, Yusuke Nakatsu, Tomoichiro Asano, Akifumi KushiyamaList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines9081052Publisher landing page
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https://www.mdpi.com/2227-9059/9/8/1052/pdf?version=1629966020Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2227-9059/9/8/1052/pdf?version=1629966020Direct OA link when available
- Concepts
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Internal medicine, Diabetes mellitus, Blood stasis, Gastroenterology, Triglyceride, Type 2 Diabetes Mellitus, Medicine, Endocrinology, Cirrhosis, Uric acid, Chemistry, Cholesterol, Traditional Chinese medicine, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2024: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.correlated | 100, 117 |
| abstract_inverted_index.disorders. | 175 |
| abstract_inverted_index.especially | 12 |
| abstract_inverted_index.hemoglobin | 90 |
| abstract_inverted_index.negatively | 112, 118 |
| abstract_inverted_index.positively | 101 |
| abstract_inverted_index.predictors | 190 |
| abstract_inverted_index.regression | 128 |
| abstract_inverted_index.thickness. | 125 |
| abstract_inverted_index.dysfunction | 110 |
| abstract_inverted_index.explanatory | 136 |
| abstract_inverted_index.inhibitors. | 47 |
| abstract_inverted_index.parameters. | 141 |
| abstract_inverted_index.transformed | 95 |
| abstract_inverted_index.associations | 2 |
| abstract_inverted_index.cholesterol. | 115 |
| abstract_inverted_index.intima-media | 124 |
| abstract_inverted_index.investigated | 18 |
| abstract_inverted_index.measurements | 197 |
| abstract_inverted_index.relationship | 158 |
| abstract_inverted_index.hypoxanthine, | 103 |
| abstract_inverted_index.relationships | 167 |
| abstract_inverted_index.characteristic | 144 |
| abstract_inverted_index.complications, | 11 |
| abstract_inverted_index.discriminatory | 148 |
| abstract_inverted_index.oxidoreductase | 6 |
| abstract_inverted_index.polyneuropathy | 15 |
| abstract_inverted_index.isotope-labeled | 59 |
| abstract_inverted_index.logarithmically | 94 |
| abstract_inverted_index.obesity-related | 174 |
| abstract_inverted_index.pre-symptomatic | 201 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5112638274 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I104946051, https://openalex.org/I4210135226 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/10 |
| sustainable_development_goals[0].score | 0.6100000143051147 |
| sustainable_development_goals[0].display_name | Reduced inequalities |
| citation_normalized_percentile.value | 0.62327737 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |