Impact of renal function impairment on kappa free light chain index Article Swipe
Martin Schmidauer
,
Fabian Föttinger
,
Klaus Berek
,
Michael Auer
,
Robert Barket
,
Franziska Di Pauli
,
Nik Krajnc
,
Markus Ponleitner
,
Anne Zinganell
,
Tobias Zrzavy
,
Florian Deisenhammer
,
Janette Walde
,
Gabriel Bsteh
,
Harald Hegen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2025-0007
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2025-0007
Objectives To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. Methods Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin quotient. Structural equation modeling (SEM) was used to evaluate the direct influence of GFR on serum κ-FLC concentration and albumin quotient (Q alb ), and via these two variables the indirect influence on CSF κ-FLC concentration. Results A total of 129 patients with a median age of 65 years and 42 % females were included. κ-FLC index ranged from 0.57 to 3.56 and glomerular filtration rate (GFR) ranged from 17 to 128 mL/min/1.73 m 2 . While a correlation of GFR with CSF κ-FLC concentration was observed (r= −0.52, p<0.001), there was no statistically significant correlation with κ-FLC index (r=0.14, p=0.113). SEM revealed that higher age was associated with lower GFR (β= −0.53), which led to higher serum κ-FLC concentration (β= −0.45) and higher Q alb (β= −0.17), while CSF κ-FLC concentration increased with serum κ-FLC concentration (β=0.75) and Q alb (β=0.39), indicating that GFR did not directly influence CSF κ-FLC concentration (RMSEA=0.043). Conclusions CSF κ-FLC concentration is not directly affected by renal function. The κ-FLC index compensates for renal function effects by factoring in serum κ-FLC concentration and Q alb . κ-FLC index can be interpreted without considering renal function.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1515/cclm-2025-0007
- https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0007/pdf
- OA Status
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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- DOI
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https://doi.org/10.1515/cclm-2025-0007Digital Object Identifier
- Title
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Impact of renal function impairment on kappa free light chain indexWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-19Full publication date if available
- Authors
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Martin Schmidauer, Fabian Föttinger, Klaus Berek, Michael Auer, Robert Barket, Franziska Di Pauli, Nik Krajnc, Markus Ponleitner, Anne Zinganell, Tobias Zrzavy, Florian Deisenhammer, Janette Walde, Gabriel Bsteh, Harald HegenList of authors in order
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https://doi.org/10.1515/cclm-2025-0007Publisher landing page
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https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0007/pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0007/pdfDirect OA link when available
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Renal function, Chemistry, Internal medicine, Endocrinology, Urology, MedicineTop concepts (fields/topics) attached by OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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