Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament Article Swipe
Anna E. B. Clements
,
Connie S. Chamberlain
,
Ellen M. Leiferman
,
William L. Murphy
,
Ray Vanderby
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.4172/2576-3881.1000113
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.4172/2576-3881.1000113
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation. Specifically, treatment resulted in a decrease in M2 (anti-inflammatory) macrophages, an increase in T cells, and an increase in the levels of IL-2, IL-6, and IL-12 in the MCL 7 days post injury. IL-17NA treatment, and subsequent immunomodulation, did not result in improved ligament healing, as measured by collagen composition and wound size.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4172/2576-3881.1000113
- OA Status
- hybrid
- Cited By
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2611135346Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4172/2576-3881.1000113Digital Object Identifier
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Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing LigamentWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2017Year of publication
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2017-01-01Full publication date if available
- Authors
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Anna E. B. Clements, Connie S. Chamberlain, Ellen M. Leiferman, William L. Murphy, Ray VanderbyList of authors in order
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https://doi.org/10.4172/2576-3881.1000113Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.4172/2576-3881.1000113Direct OA link when available
- Concepts
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Neutralization, Interleukin 1β, Interleukin, Inflammatory response, Ligament, Inflammation, Immunology, Medicine, Anatomy, Cytokine, AntibodyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2019: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| publication_year | 2017 |
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