Impaired insulin action on skeletal muscle metabolism in essential hypertension. Article Swipe
Andrea Natali
,
D Santoro
,
Carlo Palombo
,
M Cerri
,
S Ghione
,
Eleuterio Ferrannini
·
YOU?
·
· 1991
· Open Access
·
· DOI: https://doi.org/10.1161/01.hyp.17.2.170
YOU?
·
· 1991
· Open Access
·
· DOI: https://doi.org/10.1161/01.hyp.17.2.170
Previous studies have shown that essential hypertension is frequently associated with insulin resistance. The tissues responsible for this metabolic alteration have not been defined. We tested the hypothesis that skeletal muscle is the site of insulin resistance of essential hypertension with the use of the perfused forearm technique. Eight hypertensive (age 42 +/- 3 years, body mass index 27 +/- 1 kg/m2, intra-arterial mean blood pressure 126 +/- 4 mm Hg) and seven normotensive (age 48 +/- 3 years, body mass index 26 +/- 1 kg/m2, mean blood pressure 95 +/- 4 mm Hg) male volunteers were studied. After glucose ingestion (40 g/m2), normal glucose tolerance in the patients was maintained at the expense of a heightened plasma insulin response, suggesting the presence of insulin resistance. During graded, local (intra-arterial) hyperinsulinemia encompassing the physiological range (12-120 milliunits/l), glucose uptake by forearm tissues was significantly (p less than 0.03) reduced in the hypertensive subjects as compared with the controls at each of five insulin steps, by 43% on the average. In addition, forearm lactate and pyruvate release were significantly less stimulated in the hypertensive than in the normotensive group (p less than 0.01 for both), presumably as a consequence of the decreased glucose influx. Forearm exchange of oxygen, carbon dioxide, lipid substrates (free fatty acids, glycerol, and beta-hydroxybutyrate), and potassium were similar in the hypertensive and normotensive groups in the basal state. Insulin had no effect on oxygen consumption, carbon dioxide production, and respiratory quotient in either study group, whereas it stimulated free fatty acids, glycerol, and potassium uptake to the same extent in the hypertensive and normotensive groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Related Topics
Concepts
Internal medicine
Endocrinology
Hyperinsulinemia
Insulin
Insulin resistance
Essential hypertension
Blood pressure
Respiratory quotient
Forearm
Medicine
Respiratory exchange ratio
Glucose uptake
Basal (medicine)
Carbohydrate metabolism
Heart rate
Surgery
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/01.hyp.17.2.170
- https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.17.2.170
- OA Status
- bronze
- Cited By
- 146
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1968583683
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W1968583683Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/01.hyp.17.2.170Digital Object Identifier
- Title
-
Impaired insulin action on skeletal muscle metabolism in essential hypertension.Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
1991Year of publication
- Publication date
-
1991-02-01Full publication date if available
- Authors
-
Andrea Natali, D Santoro, Carlo Palombo, M Cerri, S Ghione, Eleuterio FerranniniList of authors in order
- Landing page
-
https://doi.org/10.1161/01.hyp.17.2.170Publisher landing page
- PDF URL
-
https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.17.2.170Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.17.2.170Direct OA link when available
- Concepts
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Internal medicine, Endocrinology, Hyperinsulinemia, Insulin, Insulin resistance, Essential hypertension, Blood pressure, Respiratory quotient, Forearm, Medicine, Respiratory exchange ratio, Glucose uptake, Basal (medicine), Carbohydrate metabolism, Heart rate, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
146Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 1, 2018: 1, 2017: 1, 2014: 1Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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