Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects Article Swipe
Eleonora Gallerani
,
Davide Proietto
,
Beatrice Dallan
,
Marco Campagnaro
,
Salvatore Pacifico
,
Valentina Albanese
,
Erika Marzola
,
Peggy Marconi
,
Antonella Caputo
,
Victor Appay
,
Riccardo Gavioli
,
Francesco Nicoli
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.693054
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.693054
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8 + T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8 + T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8 + T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8 + T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8 + T-cell responses.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.693054
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.693054/pdf
- OA Status
- gold
- Cited By
- 28
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3180972852
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3180972852Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2021.693054Digital Object Identifier
- Title
-
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older SubjectsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-13Full publication date if available
- Authors
-
Eleonora Gallerani, Davide Proietto, Beatrice Dallan, Marco Campagnaro, Salvatore Pacifico, Valentina Albanese, Erika Marzola, Peggy Marconi, Antonella Caputo, Victor Appay, Riccardo Gavioli, Francesco NicoliList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2021.693054Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.693054/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.693054/pdfDirect OA link when available
- Concepts
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Priming (agriculture), CD8, Immunology, Immunosenescence, Immune system, Cytotoxic T cell, T cell, Immunity, Senescence, Medicine, Biology, In vitro, Internal medicine, Genetics, Germination, BotanyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 4, 2023: 5, 2022: 11, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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47Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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