Impairment of White Matter Microstructure in Alcohol Use Disorders and Its Association With Symptoms Article Swipe
Sijia He
,
Qinghui Zhang
,
Li Wan
,
Yang Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31083/jin37538
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31083/jin37538
Background: Alcohol use disorder (AUD) is a global health concern, with alcohol abuse leading to structural damage to white matter (WM) fiber tracts, which are crucial for cognitive and emotional functions. However, existing studies often lack systematic evaluations of these changes and their clinical correlations. Methods: Using tract-based spatial statistics (TBSS), we analyzed diffusion tensor imaging (DTI) data from 20 AUD patients and 20 healthy controls. Correlations between fractional anisotropy (FA) values and clinical symptoms, including cognitive dysfunction, depression, and impulsivity, were examined. Results: AUD patients presented significantly decreased FA values in the right corpus callosum, right fornix, left inferior fronto-occipital fasciculus, and left cerebral white matter. The FA peak values of the right fornix and the left cerebral white matter were positively and significantly correlated with cognitive function scores in the AUD group after controlling for smoking status, age, and years of education. Conclusions: Alcohol abuse significantly impairs WM integrity, particularly in regions related to cognitive and emotional regulation. These findings provide structural evidence for the neurobiological mechanisms of AUD and suggest that FA may serve as a potential biomarker for assessing brain damage, guiding therapeutic interventions.
Related Topics
Concepts
Fornix
Fractional anisotropy
White matter
Corpus callosum
Diffusion MRI
Inferior longitudinal fasciculus
Psychology
Cognition
Fasciculus
Alcohol abuse
Medicine
Uncinate fasciculus
Psychiatry
Clinical psychology
Audiology
Internal medicine
Neuroscience
Magnetic resonance imaging
Radiology
Hippocampus
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31083/jin37538
- https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN37538/pdf
- OA Status
- gold
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411969743
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411969743Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31083/jin37538Digital Object Identifier
- Title
-
Impairment of White Matter Microstructure in Alcohol Use Disorders and Its Association With SymptomsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-17Full publication date if available
- Authors
-
Sijia He, Qinghui Zhang, Li Wan, Yang LiuList of authors in order
- Landing page
-
https://doi.org/10.31083/jin37538Publisher landing page
- PDF URL
-
https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN37538/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN37538/pdfDirect OA link when available
- Concepts
-
Fornix, Fractional anisotropy, White matter, Corpus callosum, Diffusion MRI, Inferior longitudinal fasciculus, Psychology, Cognition, Fasciculus, Alcohol abuse, Medicine, Uncinate fasciculus, Psychiatry, Clinical psychology, Audiology, Internal medicine, Neuroscience, Magnetic resonance imaging, Radiology, HippocampusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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26Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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