Implanted chemical sensors for functional radiography Article Swipe
Md Arifuzzaman
,
Paul W. Millhouse
,
Yash S. Raval
,
Thomas B. Pace
,
Caleb Behrend
,
John D. DesJardins
,
Tzuen‐Rong Tzeng
,
Jeffrey N. Anker
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.5426023
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.5426023
A biomedical sensor is designed to noninvasively measure local pH changes on the surface of implanted devices for detecting and monitoring implant-associated infection using plain radiography. The sensor comprises a radiopaque pin embedded within a polyacrylic acid-based hydrogel. pH-modulated hydrogel expansion and contraction is determined by radiographically measuring the pin position. The sensor was calibrated in a series of standard pH buffers, and tested in a bacterial growth culture. The sensor calibration was insensitive to changes in temperature and ionic strength within the normal physiological range. The response time depended on sensor thickness, and was approximately 30 min for 1 mm thick films. Radiographic measurements were also performed through tissue and bone with the sensor attached to an orthopedic plate fixated to a human cadaver tibia. Plain radiographs were selected for readout since X-rays are routinely used in inpatient and outpatient settings for structural or anatomical information. The chemically-responsive hydrogel sensors can provide additional functional information in a clinical setting by indicating local chemical concentrations near the implant surface using routinely obtained radiographs.
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- Type
- preprint
- Language
- en
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- https://doi.org/10.26434/chemrxiv.5426023
- OA Status
- gold
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- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4238045019Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26434/chemrxiv.5426023Digital Object Identifier
- Title
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Implanted chemical sensors for functional radiographyWork title
- Type
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preprintOpenAlex work type
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enPrimary language
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2017Year of publication
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2017-01-01Full publication date if available
- Authors
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Md Arifuzzaman, Paul W. Millhouse, Yash S. Raval, Thomas B. Pace, Caleb Behrend, John D. DesJardins, Tzuen‐Rong Tzeng, Jeffrey N. AnkerList of authors in order
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https://doi.org/10.26434/chemrxiv.5426023Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.26434/chemrxiv.5426023Direct OA link when available
- Concepts
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Radiography, Biomedical engineering, Materials science, Cadaver, Implant, Medicine, Radiology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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