Implementation of the ProMisE classifier and validation of its prognostic impact in Brazilian endometrial carcinomas Article Swipe
Diocésio Alves Pinto de Andrade
,
Murilo Bonatelli
,
Flávia Escremim de Paula
,
Gustavo Nóriz Berardinelli
,
Gustavo Ramos Teixeira
,
Monise Tadin Reis
,
Flávia Fazzio Barbin
,
Carlos Eduardo Mattos da Cunha Andrade
,
Vinicius Pereira Aguiar
,
Alejandro Delfos Hermoza
,
Welinton Yoshio Hirai
,
Ronaldo Luís Schmidt
,
Rui Manuel Reis
,
Rui Manuel Reis
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1503901
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1503901
Purpose Molecular classification of endometrial cancer (EC) has emerged as a key approach to individualize therapy and define prognostic outcomes. This study aimed to implement the traditional ProMisE classification in a Brazilian population, compared with a molecular setting of ProMisE biomarkers, and evaluate its impact on patients’ prognosis. Patient and methods A prospective cohort of 114 patients with primary EC treated at Barretos Cancer Hospital (BCH) between October 2020 and December 2022 was conducted. Pathology diagnosis, staging, treatment, and follow-up data were collected. The traditional ProMisE methodology was carried out by POLE hotspot sequencing and immunohistochemistry (IHC) for p53 and mismatch repair (MMR) proteins. We further evaluate the MMR and TP53 status by molecular approach, namely microsatellite instability (MSI) by PCR-based and TP53 mutation analysis by next-generation sequencing (NGS). The results of the 4 molecular groups in both methodologies were compared regarding agreement accuracy and survival outcomes. Results Among the 114 cases, the traditional ProMisE groups were: POLE mut 15.8%, MMRd 28.1%, p53abn 27.2%, and no specific molecular profile (NSMP) 28.9%. Considering the molecular classification approach, we observed a POLE mut group of 15.8% , MSI group of 23.7%, TP53 mutation of 27.2%, and NSMP of 33.3%. The concordance rate of both approaches was 86.8% (99/114 cases) with an overall accuracy of 0.87. Importantly, both traditional and molecular ProMisE approaches were associated with significant distinct overall survival (OS) and progression-free survival (PFS) outcomes, with POLE mut patients exhibiting a better prognosis (93.8% OS, at 24 months), whereas the p53abn having a worse survival time (68.9% of OS, at 24 months). Conclusion We reported for the first time the Brazilian profile of the ProMisE classification of endometrial cancer and demonstrated the prognostic impact of the traditional and molecular ProMisE classification on patient outcomes.
Related Topics
Concepts
Microsatellite instability
Concordance
Oncology
Endometrial cancer
Medicine
Internal medicine
Cohort
DNA mismatch repair
Targeted therapy
Immunohistochemistry
Population
Bioinformatics
Cancer
Biology
Microsatellite
Gene
Genetics
Colorectal cancer
Environmental health
Allele
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2024.1503901
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1503901/pdf
- OA Status
- gold
- Cited By
- 2
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405383433
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405383433Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fonc.2024.1503901Digital Object Identifier
- Title
-
Implementation of the ProMisE classifier and validation of its prognostic impact in Brazilian endometrial carcinomasWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-13Full publication date if available
- Authors
-
Diocésio Alves Pinto de Andrade, Murilo Bonatelli, Flávia Escremim de Paula, Gustavo Nóriz Berardinelli, Gustavo Ramos Teixeira, Monise Tadin Reis, Flávia Fazzio Barbin, Carlos Eduardo Mattos da Cunha Andrade, Vinicius Pereira Aguiar, Alejandro Delfos Hermoza, Welinton Yoshio Hirai, Ronaldo Luís Schmidt, Rui Manuel Reis, Rui Manuel ReisList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2024.1503901Publisher landing page
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1503901/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1503901/pdfDirect OA link when available
- Concepts
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Microsatellite instability, Concordance, Oncology, Endometrial cancer, Medicine, Internal medicine, Cohort, DNA mismatch repair, Targeted therapy, Immunohistochemistry, Population, Bioinformatics, Cancer, Biology, Microsatellite, Gene, Genetics, Colorectal cancer, Environmental health, AlleleTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4393935425, https://openalex.org/W3097551677, https://openalex.org/W2044869180, https://openalex.org/W2041440766, https://openalex.org/W1565078991, https://openalex.org/W2081748041, https://openalex.org/W4380841452, https://openalex.org/W3114074286, https://openalex.org/W4385534695, https://openalex.org/W3092284014, https://openalex.org/W4313447346, https://openalex.org/W4395959955, https://openalex.org/W2093274439, https://openalex.org/W4252515531, https://openalex.org/W2809528751, https://openalex.org/W4256372519, https://openalex.org/W4224981640, https://openalex.org/W2925280531, https://openalex.org/W2054987308, https://openalex.org/W4363645308, https://openalex.org/W2793281906, https://openalex.org/W3214236638, https://openalex.org/W4388653468, https://openalex.org/W4321018485, https://openalex.org/W4386333989, https://openalex.org/W3164034212, https://openalex.org/W4391042392, https://openalex.org/W3214278620, https://openalex.org/W3188862626, https://openalex.org/W3118338742, https://openalex.org/W4386996812, https://openalex.org/W4380202702, https://openalex.org/W1995795701, https://openalex.org/W4237875094, https://openalex.org/W4283520680 |
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