Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgery Article Swipe
Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgeryBackground. Obesity has become a global epidemic and carries excess cardiovascular (CV) morbidity and mortality. Bariatric surgery was shown to improve significantly CV outcome. HDL cholesterol efflux capacity (CEC) was shown to be inversely correlated with cardiovascular risk (CVR), both in the acute and the chronic phases. Our aim is to assess if HDL CEC is improved 6 months post bariatric surgery in comparison to baseline, as a surrogate marker for the increased CVR reduction in the morbidly obese population. Methods. HDL CEC via ATP-binding cassette A1 (ABCA1), ATP-binding cassette G1 (ABCG1) and scavenger receptor BI (SR-BI) was measured for morbidly obese individuals prior to and 6 months after bariatric surgery. HDL CEC was measured using radioactive cell-based assays. Results. Plasma from 36 morbidly obese patients was analyzed. The mean age of the patients was 43.2±12.2 years, 30.6% of the patients were males, 61.1% had undergone sleeve gastrectomy (SG) and 38.9% Roux-en-Y gastric bypass. HDL CEC improved 6 months post-bariatric surgery in comparison to baseline for all 3 transporters as well as unstimulated total CEC; efflux via ABCA1 increased by 9.5% (14.35±1.85 vs. 13.1±2.63, P=0.004), via ABCG1 by 14% (4.38±0.95 vs. 3.84±0.84, P=0.001), via SR-BI by 14.1% (5.96±0.99 vs. 5.23±0.89, P<0.001) and unstimulated total efflux increased by 14.8% (8.82±1.3 vs. 7.68±0.93, P<0.001). Discussion. In the current study, we found that HDL CEC through ABCA1, ABCG1 and SR-BI improved significantly in morbidly obese individuals 6 months after bariatric surgery. Efflux is an ongoing process, hence even a small improvement in CEC can have a substantial effect on the atherosclerotic plaque. Given that HDL CEC has an inverse correlation with CVR, these findings may explain, at least in part, the improvement in CVR in morbidly obese patients post-bariatric surgery. Conclusion. HDL CEC improves after bariatric surgery, and may play an important role in the favorable CV outcome seen in obese patients post-bariatric surgery. If the same is proven in larger clinical studies, decreased HDL CEC might serve as another indication for bariatric surgery in obese individuals.
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- Type
- article
- Language
- en
- Landing Page
- https://escholarship.mcgill.ca/concern/theses/kp78gj96b
- https://escholarship.mcgill.ca/concern/theses/kp78gj96b
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3175192143Canonical identifier for this work in OpenAlex
- Title
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Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgeryWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
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2017-01-01Full publication date if available
- Authors
-
Idit DotanList of authors in order
- Landing page
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https://escholarship.mcgill.ca/concern/theses/kp78gj96bPublisher landing page
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https://escholarship.mcgill.ca/concern/theses/kp78gj96bDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://escholarship.mcgill.ca/concern/theses/kp78gj96bDirect OA link when available
- Concepts
-
Morbidly obese, Obesity, Medicine, Cholesterol, Efflux, Obesity Surgery, Surgery, Weight loss, Internal medicine, Gastric bypass, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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20Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(5.96±0.99 | 208 |
| abstract_inverted_index.13.1±2.63, | 194 |
| abstract_inverted_index.3.84±0.84, | 202 |
| abstract_inverted_index.5.23±0.89, | 210 |
| abstract_inverted_index.7.68±0.93, | 221 |
| abstract_inverted_index.significantly | 32, 239 |
| abstract_inverted_index.(14.35±1.85 | 192 |
| abstract_inverted_index.cardiovascular | 21, 47 |
| abstract_inverted_index.post-bariatric | 170, 296, 320 |
| abstract_inverted_index.P&lt;0.001) | 211 |
| abstract_inverted_index.atherosclerotic | 268 |
| abstract_inverted_index.P&lt;0.001). | 222 |
| abstract_inverted_index.surgeryBackground. | 11 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5037816652 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 1 |
| citation_normalized_percentile |