Improvement of irradiation-induced fibroblast damage by α2-macroglobulin through alleviating mitochondrial dysfunction Article Swipe

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Apoptosis Flow cytometry Fibroblast Viability assay Superoxide dismutase Oxidative stress Molecular biology Chemistry Cell growth Biology Biochemistry In vitro

Chaoji Huangfu , Nan Tang , Xiaokun Yang , Gong Zhan-wei , Junzheng Li , Junting Jia , Jingang Zhang , Yan Huang , Yuyuan Ma ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1080/13880209.2022.2096077 · OA: W4288036932

α2-M significantly promoted the decreased fibroblast viability and improved the mitochondria dysfunction caused by irradiation. α2-M might present anti-radiation effect through alleviating mitochondrial dysfunction caused by irradiation. This study could provide a novel understanding about the improvement of α2-M on irradiation-induced injury.