BMC Genomics • Vol 25 • No 1
Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2
September 2024 • Jonathan P. Tyrer, Pei-Chen Peng, Amber A DeVries, Simon A Gayther, Michelle R. Jones, Paul D.P. Pharoah
Taken together, the S4 + LDpred2 method represents an improvement in overall PGS accuracy across multiple phenotypes and populations.