Improving the understanding of mammalian microRNAs: from annotation, isomiR and function Article Swipe
MicroRNAs (miRNAs) are a class of small non-coding RNAs, ~22nt. They have extensive roles in gene expression regulation, fine-tuning a wide range of biological processes. Next-generation sequencing is currently a widely used approach to study miRNA expression level in samples. A bioinformatic analysis pipeline commonly implemented to investigate the miRNA-seq data. \nWe find that (1) adapter information is important in the small RNA-seq studies; (2) miRNA annotation content in miRBase need to be curtated before used in mapping as reference; (3) developed a hierarchical isomiR nomenclature and implement it within a publicly available analysis pipeline, Jasmine; (4) developed a deep neural network based approach, miRAW, for miRNA target prediction.\nOverall, the works presented in this thesis demonstrate that bioinformatic analysis pipeline can affect our understanding of mammalian microRNAs, to some degree; and highlight the importance of implementing robust and reliable bioinformatic methods in miRNA-seq studies, especially in medical related research fields.
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Metadata
- Type
- dissertation
- Language
- en
- Landing Page
- http://hdl.handle.net/10852/78825
- http://urn.nb.no/URN:NBN:no-81935
- OA Status
- green
- Related Works
- 8
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3162264782Canonical identifier for this work in OpenAlex
- Title
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Improving the understanding of mammalian microRNAs: from annotation, isomiR and functionWork title
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-
dissertationOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Xiangfu ZhongList of authors in order
- Landing page
-
https://hdl.handle.net/10852/78825Publisher landing page
- PDF URL
-
https://urn.nb.no/URN:NBN:no-81935Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://urn.nb.no/URN:NBN:no-81935Direct OA link when available
- Concepts
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Annotation, Function (biology), microRNA, Computational biology, Biology, Computer science, Data science, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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8Other works algorithmically related by OpenAlex
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