In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistance Article Swipe
Ahmed Ibrahim AbdElneam
,
Sharif Alhajlah
,
Mohammed Saleh Al‐Dhubaibi
,
Saleh Salem Bahaj
,
Ghada Farouk Mohammed
,
Ahmed Kaid Alantry
,
Lina Mohammed Atef
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/srt.13811
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/srt.13811
Background Acne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on the face, upper limbs, torso, and back, with comedones formation being the primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, and psychological impact. Aim The purpose of this study was to investigate the significance of two genetic variants in the promoter region of the tumor necrosis factor‐alpha (TNF‐α) gene and their association with insulin resistance (IR) in acne patients. To understand how these variants contribute to AV and its associated IR. Subjects and methods An analytical cross‐sectional study with a case‐control design and research evaluation was carried out on 87 AV patients and 73 healthy volunteers. The medical histories of both groups were obtained, as well as the severity and duration of inflammation among acne sufferers, as well as demographic data. Biochemical analysis was performed on both sets of participants, including fasting blood glucose levels, insulin levels while fasting, IR, and serum TNF‐α. PCR‐RFLP analysis identified −863 G > A (rs1800630) and −308 G > A (rs1800629) variations, and real‐time PCR analysis evaluated TNF‐α gene expression in both patients and healthy people. Results Acne patients exhibited significantly higher levels of IR, fasting glucose, fasting insulin, serum TNF‐α, and TNF‐α folding change, when compared to healthy controls. The co‐dominant model for −863 G > A and −308 G > A variants exhibited significant variations between the two groups. Severe acne patients who had the A/A genotype for −308 variants exhibited higher levels of IR, serum TNF‐α, and TNF‐α folding change. Highly significant positive linear correlation between IR, serum TNF‐α, and TNF‐α folding change in severe AV. Conclusion There is a correlation between AV, especially severe acne, and the −863 G > A and −308 G > A polymorphism, which influences TNF‐α gene expression and serum TNF‐α levels.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/srt.13811
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/srt.13811
- OA Status
- hybrid
- Cited By
- 4
- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400006062Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/srt.13811Digital Object Identifier
- Title
-
In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistanceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-25Full publication date if available
- Authors
-
Ahmed Ibrahim AbdElneam, Sharif Alhajlah, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Ahmed Kaid Alantry, Lina Mohammed AtefList of authors in order
- Landing page
-
https://doi.org/10.1111/srt.13811Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/srt.13811Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/srt.13811Direct OA link when available
- Concepts
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Acne, Medicine, Insulin resistance, Tumor necrosis factor alpha, Genotype, Internal medicine, Diabetes mellitus, Inflammation, Insulin, Gastroenterology, Endocrinology, Gene, Dermatology, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.pathology | 37 |
| abstract_inverted_index.patients. | 82 |
| abstract_inverted_index.performed | 148 |
| abstract_inverted_index.pustules, | 20 |
| abstract_inverted_index.scarring, | 43 |
| abstract_inverted_index.(TNF‐α) | 71 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 279 |
| abstract_inverted_index.PCR‐RFLP | 167 |
| abstract_inverted_index.analytical | 99 |
| abstract_inverted_index.associated | 93 |
| abstract_inverted_index.comedones, | 18 |
| abstract_inverted_index.contribute | 88 |
| abstract_inverted_index.especially | 286 |
| abstract_inverted_index.evaluation | 108 |
| abstract_inverted_index.expression | 189, 305 |
| abstract_inverted_index.identified | 169 |
| abstract_inverted_index.influences | 302 |
| abstract_inverted_index.presenting | 16 |
| abstract_inverted_index.resistance | 78 |
| abstract_inverted_index.sufferers, | 139 |
| abstract_inverted_index.understand | 84 |
| abstract_inverted_index.variations | 236 |
| abstract_inverted_index.(rs1800629) | 180 |
| abstract_inverted_index.(rs1800630) | 174 |
| abstract_inverted_index.Biochemical | 145 |
| abstract_inverted_index.association | 75 |
| abstract_inverted_index.correlation | 267, 283 |
| abstract_inverted_index.demographic | 143 |
| abstract_inverted_index.disfiguring | 40 |
| abstract_inverted_index.investigate | 55 |
| abstract_inverted_index.real‐time | 183 |
| abstract_inverted_index.significant | 235, 264 |
| abstract_inverted_index.variations, | 181 |
| abstract_inverted_index.volunteers. | 119 |
| abstract_inverted_index.inflammation | 136 |
| abstract_inverted_index.inflammatory | 8 |
| abstract_inverted_index.significance | 57 |
| abstract_inverted_index.co‐dominant | 221 |
| abstract_inverted_index.inflammation, | 41 |
| abstract_inverted_index.participants, | 153 |
| abstract_inverted_index.pilosebaceous | 13 |
| abstract_inverted_index.polymorphism, | 300 |
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| abstract_inverted_index.case‐control | 104 |
| abstract_inverted_index.factor‐alpha | 70 |
| abstract_inverted_index.cross‐sectional | 100 |
| abstract_inverted_index.hyperpigmentation, | 42 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5076152670 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I170535673 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.90107431 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |