In silico medical device testing of anatomically and mechanically conforming patient-specific spinal fusion cages designed by full-scale topology optimisation Article Swipe
Thijs Smit
,
Niels Aage
,
Daniel Haschtmann
,
Stephen J. Ferguson
,
Benedikt Helgason
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2024.1347961
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2024.1347961
A full-scale topology optimisation formulation has been developed to automate the design of cages used in instrumented transforaminal lumbar interbody fusion. The method incorporates the mechanical response of the adjacent bone structures in the optimisation process, yielding patient-specific spinal fusion cages that both anatomically and mechanically conform to the patient, effectively mitigating subsidence risk compared to generic, off-the-shelf cages and patient-specific devices. In this study, in silico medical device testing on a cohort of seven patients was performed to investigate the effectiveness of the anatomically and mechanically conforming devices using titanium and PEEK implant materials. A median reduction in the subsidence risk by 89% for titanium and 94% for PEEK implant materials was demonstrated compared to an off-the-shelf implant. A median reduction of 75% was achieved for a PEEK implant material compared to an anatomically conforming implant. A credibility assessment of the computational model used to predict the subsidence risk was provided according to the ASME V&V40–2018 standard.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2024.1347961
- OA Status
- gold
- Cited By
- 2
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402418940
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4402418940Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fbioe.2024.1347961Digital Object Identifier
- Title
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In silico medical device testing of anatomically and mechanically conforming patient-specific spinal fusion cages designed by full-scale topology optimisationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-10Full publication date if available
- Authors
-
Thijs Smit, Niels Aage, Daniel Haschtmann, Stephen J. Ferguson, Benedikt HelgasonList of authors in order
- Landing page
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https://doi.org/10.3389/fbioe.2024.1347961Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fbioe.2024.1347961Direct OA link when available
- Concepts
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In silico, Topology (electrical circuits), Scale (ratio), Computer science, Fusion, Biomedical engineering, Medicine, Engineering, Biology, Physics, Electrical engineering, Quantum mechanics, Gene, Linguistics, Biochemistry, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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56Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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