In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design Article Swipe
Omar Omar
,
Thomas Engstrand
,
Lars Linder
,
Jonas Åberg
,
Furqan A. Shah
,
Anders Palmquist
,
Ulrik Birgersson
,
Ibrahim Elgali
,
Michael Pujari‐Palmer
,
Håkan Engqvist
,
Peter Thomsen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2007635117
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2007635117
Significance Large cranial reconstructions are increasingly performed worldwide and still represent a substantial clinical challenge. The gold standard, autologous bone, has limited availability and high donor-site morbidity. Current alloplastic materials are associated with high complication and failure rates. This study shows the capacity of a customized, purely synthetic, 3D-manufactured bioceramic implant to regenerate and restore large cranial defects with mature, well-vascularized bone, with a morphology, ultrastructure, and composition similar to those of native skull bone. This approach triggers the regenerative potential of host tissue by tailoring the implant composition and design. The regeneration of large defects using purely synthetic material without adjunct cell therapy or growth factors represents a major advancement for rehabilitating patients in need of large cranial reconstructions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2007635117
- https://www.pnas.org/content/pnas/117/43/26660.full.pdf
- OA Status
- bronze
- Cited By
- 65
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3091842446
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3091842446Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2007635117Digital Object Identifier
- Title
-
In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and designWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-10-12Full publication date if available
- Authors
-
Omar Omar, Thomas Engstrand, Lars Linder, Jonas Åberg, Furqan A. Shah, Anders Palmquist, Ulrik Birgersson, Ibrahim Elgali, Michael Pujari‐Palmer, Håkan Engqvist, Peter ThomsenList of authors in order
- Landing page
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https://doi.org/10.1073/pnas.2007635117Publisher landing page
- PDF URL
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https://www.pnas.org/content/pnas/117/43/26660.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.pnas.org/content/pnas/117/43/26660.full.pdfDirect OA link when available
- Concepts
-
Bioceramic, Regeneration (biology), Skull, Cranial bone, Implant, Materials science, Biomedical engineering, Dentistry, Soft tissue, Medicine, Surgery, Biology, Nanotechnology, Cell biologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
65Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 17, 2024: 14, 2023: 10, 2022: 18, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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68Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2521048046, https://openalex.org/W2768541889, https://openalex.org/W2595523773, https://openalex.org/W2025657683, https://openalex.org/W2153268483, https://openalex.org/W2092037514, https://openalex.org/W2070197586, https://openalex.org/W2032740145, https://openalex.org/W2102169821, https://openalex.org/W2068385744, https://openalex.org/W2113398281, https://openalex.org/W2615546161, https://openalex.org/W2089469704, https://openalex.org/W2911786443, https://openalex.org/W2164833748, https://openalex.org/W2261324366, https://openalex.org/W2151005356, https://openalex.org/W6777587450, https://openalex.org/W2239351012, https://openalex.org/W2075739534, https://openalex.org/W4317523403, https://openalex.org/W2115327066, https://openalex.org/W2900099262, https://openalex.org/W2226018108, https://openalex.org/W2125858131, https://openalex.org/W2588779003, https://openalex.org/W1998138772, https://openalex.org/W2022692623, https://openalex.org/W2067045707, https://openalex.org/W2123231503, https://openalex.org/W2035830337, https://openalex.org/W2474164930, https://openalex.org/W2159695232, https://openalex.org/W2418609691, https://openalex.org/W2225513920, https://openalex.org/W2081072323, https://openalex.org/W2744322609, https://openalex.org/W2119763108, https://openalex.org/W2093512399, https://openalex.org/W2063998346, https://openalex.org/W2530377730, https://openalex.org/W2037368638, https://openalex.org/W2034815624, https://openalex.org/W2427718586, https://openalex.org/W2782580194, https://openalex.org/W2138546131, https://openalex.org/W2256556254, https://openalex.org/W2284681374, https://openalex.org/W1873123281, https://openalex.org/W2320724958, https://openalex.org/W2023529781, https://openalex.org/W2753782603, https://openalex.org/W2005720246, https://openalex.org/W1846776373, https://openalex.org/W2774871777, https://openalex.org/W1573807422, https://openalex.org/W1562125623, https://openalex.org/W1965505631, https://openalex.org/W1968067319, https://openalex.org/W2125284983, https://openalex.org/W2148606646, https://openalex.org/W2051036247, https://openalex.org/W2294761879, https://openalex.org/W1973238075, https://openalex.org/W2043383158, https://openalex.org/W1601103901, https://openalex.org/W1813865561, https://openalex.org/W3127034400 |
| referenced_works_count | 68 |
| abstract_inverted_index.a | 11, 44, 63, 108 |
| abstract_inverted_index.by | 84 |
| abstract_inverted_index.in | 114 |
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| abstract_inverted_index.to | 51, 69 |
| abstract_inverted_index.The | 15, 91 |
| abstract_inverted_index.and | 8, 23, 35, 53, 66, 89 |
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| abstract_inverted_index.large | 55, 94, 117 |
| abstract_inverted_index.major | 109 |
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| abstract_inverted_index.design. | 90 |
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| abstract_inverted_index.patients | 113 |
| abstract_inverted_index.triggers | 77 |
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| abstract_inverted_index.worldwide | 7 |
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| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.91562596 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |