In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening Article Swipe
Nunzio Iraci
,
Carmine Ostacolo
,
Alicia Medina-Peris
,
Tania Ciaglia
,
Anton M. Novoselov
,
Andrea Altieri
,
David Cabañero
,
Asia Fernández‐Carvajal
,
Pietro Campiglia
,
Isabel Gómez‐Monterrey
,
Alessia Bertamino
,
Alexander V. Kurkin
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23042070
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23042070
Transient receptor potential melastatin type 8 (TRPM8) is a target for the treatment of different physio-pathological processes. While TRPM8 antagonists are reported as potential drugs for pain, cancer, and inflammation, to date only a limited number of chemotypes have been investigated and thus a limited number of compounds have reached clinical trials. Hence there is high value in searching for new TRPM8 antagonistic to broaden clues to structure-activity relationships, improve pharmacological properties and explore underlying molecular mechanisms. To address this, the EDASA Scientific in-house molecular library has been screened in silico, leading to identifying twenty-one potentially antagonist compounds of TRPM8. Calcium fluorometric assays were used to validate the in-silico hypothesis and assess compound selectivity. Four compounds were identified as selective TRPM8 antagonists, of which two were dual-acting TRPM8/TRPV1 modulators. The most potent TRPM8 antagonists (BB 0322703 and BB 0322720) underwent molecular modelling studies to highlight key structural features responsible for drug–protein interaction. The two compounds were also investigated by patch-clamp assays, confirming low micromolar potencies. The most potent compound (BB 0322703, IC50 1.25 ± 0.26 μM) was then profiled in vivo in a cold allodinya model, showing pharmacological efficacy at 30 μM dose. The new chemotypes identified showed remarkable pharmacological properties paving the way to further investigations for drug discovery and pharmacological purposes.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms23042070
- https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358
- OA Status
- gold
- Cited By
- 6
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4213216912
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4213216912Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms23042070Digital Object Identifier
- Title
-
In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical ScreeningWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-13Full publication date if available
- Authors
-
Nunzio Iraci, Carmine Ostacolo, Alicia Medina-Peris, Tania Ciaglia, Anton M. Novoselov, Andrea Altieri, David Cabañero, Asia Fernández‐Carvajal, Pietro Campiglia, Isabel Gómez‐Monterrey, Alessia Bertamino, Alexander V. KurkinList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms23042070Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358Direct OA link when available
- Concepts
-
In vivo, Chemotype, In vitro, Pharmacology, Chemistry, Computational biology, Biology, Biochemistry, Biotechnology, Chromatography, Essential oilTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4213216912 |
|---|---|
| doi | https://doi.org/10.3390/ijms23042070 |
| ids.doi | https://doi.org/10.3390/ijms23042070 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35216186 |
| ids.openalex | https://openalex.org/W4213216912 |
| fwci | 1.31758994 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000379 |
| mesh[1].descriptor_ui | D055808 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | methods |
| mesh[1].descriptor_name | Drug Discovery |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D051379 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Mice |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D008810 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Mice, Inbred C57BL |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D013329 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Structure-Activity Relationship |
| mesh[6].qualifier_ui | Q000037 |
| mesh[6].descriptor_ui | D050053 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | antagonists & inhibitors |
| mesh[6].descriptor_name | TRPM Cation Channels |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000818 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Animals |
| mesh[8].qualifier_ui | Q000379 |
| mesh[8].descriptor_ui | D055808 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | methods |
| mesh[8].descriptor_name | Drug Discovery |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005260 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Female |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D051379 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Mice |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008810 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Mice, Inbred C57BL |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D013329 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Structure-Activity Relationship |
| mesh[13].qualifier_ui | Q000037 |
| mesh[13].descriptor_ui | D050053 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | antagonists & inhibitors |
| mesh[13].descriptor_name | TRPM Cation Channels |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000818 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Animals |
| mesh[15].qualifier_ui | Q000379 |
| mesh[15].descriptor_ui | D055808 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | methods |
| mesh[15].descriptor_name | Drug Discovery |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D005260 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Female |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D051379 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Mice |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008810 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice, Inbred C57BL |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D013329 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Structure-Activity Relationship |
| mesh[20].qualifier_ui | Q000037 |
| mesh[20].descriptor_ui | D050053 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | antagonists & inhibitors |
| mesh[20].descriptor_name | TRPM Cation Channels |
| type | article |
| title | In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening |
| awards[0].id | https://openalex.org/G3454750142 |
| awards[0].funder_id | https://openalex.org/F4320322218 |
| awards[0].funder_award_id | B61G18000470007 |
| awards[0].funder_display_name | Regione Campania |
| biblio.issue | 4 |
| biblio.volume | 23 |
| biblio.last_page | 2070 |
| biblio.first_page | 2070 |
| grants[0].funder | https://openalex.org/F4320322218 |
| grants[0].award_id | B61G18000470007 |
| grants[0].funder_display_name | Regione Campania |
| topics[0].id | https://openalex.org/T12356 |
| topics[0].field.id | https://openalex.org/fields/30 |
| topics[0].field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| topics[0].score | 0.9991999864578247 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3005 |
| topics[0].subfield.display_name | Toxicology |
| topics[0].display_name | Bioactive Compounds and Antitumor Agents |
| topics[1].id | https://openalex.org/T11204 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9987000226974487 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2809 |
| topics[1].subfield.display_name | Sensory Systems |
| topics[1].display_name | Ion Channels and Receptors |
| topics[2].id | https://openalex.org/T13792 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9527000188827515 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2707 |
| topics[2].subfield.display_name | Complementary and alternative medicine |
| topics[2].display_name | Morinda citrifolia extract uses |
| funders[0].id | https://openalex.org/F4320322218 |
| funders[0].ror | https://ror.org/02kg21794 |
| funders[0].display_name | Regione Campania |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C207001950 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7565258741378784 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[0].display_name | In vivo |
| concepts[1].id | https://openalex.org/C153784791 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6771611571311951 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2212766 |
| concepts[1].display_name | Chemotype |
| concepts[2].id | https://openalex.org/C202751555 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6201488375663757 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[2].display_name | In vitro |
| concepts[3].id | https://openalex.org/C98274493 |
| concepts[3].level | 1 |
| concepts[3].score | 0.4578823149204254 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[3].display_name | Pharmacology |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.3861631155014038 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C70721500 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3831390142440796 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[5].display_name | Computational biology |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.3566969633102417 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.19340062141418457 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C150903083 |
| concepts[8].level | 1 |
| concepts[8].score | 0.14740359783172607 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7108 |
| concepts[8].display_name | Biotechnology |
| concepts[9].id | https://openalex.org/C43617362 |
| concepts[9].level | 1 |
| concepts[9].score | 0.07159847021102905 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[9].display_name | Chromatography |
| concepts[10].id | https://openalex.org/C2777278459 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q170885 |
| concepts[10].display_name | Essential oil |
| keywords[0].id | https://openalex.org/keywords/in-vivo |
| keywords[0].score | 0.7565258741378784 |
| keywords[0].display_name | In vivo |
| keywords[1].id | https://openalex.org/keywords/chemotype |
| keywords[1].score | 0.6771611571311951 |
| keywords[1].display_name | Chemotype |
| keywords[2].id | https://openalex.org/keywords/in-vitro |
| keywords[2].score | 0.6201488375663757 |
| keywords[2].display_name | In vitro |
| keywords[3].id | https://openalex.org/keywords/pharmacology |
| keywords[3].score | 0.4578823149204254 |
| keywords[3].display_name | Pharmacology |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.3861631155014038 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/computational-biology |
| keywords[5].score | 0.3831390142440796 |
| keywords[5].display_name | Computational biology |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.3566969633102417 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.19340062141418457 |
| keywords[7].display_name | Biochemistry |
| keywords[8].id | https://openalex.org/keywords/biotechnology |
| keywords[8].score | 0.14740359783172607 |
| keywords[8].display_name | Biotechnology |
| keywords[9].id | https://openalex.org/keywords/chromatography |
| keywords[9].score | 0.07159847021102905 |
| keywords[9].display_name | Chromatography |
| language | en |
| locations[0].id | doi:10.3390/ijms23042070 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms23042070 |
| locations[1].id | pmid:35216186 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35216186 |
| locations[2].id | pmh:oai:doaj.org/article:4f65b702d38543b09911324c2544a284 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | International Journal of Molecular Sciences, Vol 23, Iss 2070, p 2070 (2022) |
| locations[2].landing_page_url | https://doaj.org/article/4f65b702d38543b09911324c2544a284 |
| locations[3].id | pmh:oai:mdpi.com:/1422-0067/23/4/2070/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 2070 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/ijms23042070 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8877448 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Int J Mol Sci |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8877448 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5074044188 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1359-8684 |
| authorships[0].author.display_name | Nunzio Iraci |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I112862951 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I112862951 |
| authorships[0].institutions[0].ror | https://ror.org/05ctdxz19 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I112862951 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Messina |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Nunzio Iraci |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy |
| authorships[1].author.id | https://openalex.org/A5020033317 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3715-8680 |
| authorships[1].author.display_name | Carmine Ostacolo |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I71267560 |
| authorships[1].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Naples Federico II |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Carmine Ostacolo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy |
| authorships[2].author.id | https://openalex.org/A5033161987 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8035-0179 |
| authorships[2].author.display_name | Alicia Medina-Peris |
| authorships[2].countries | ES |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I111262870 |
| authorships[2].affiliations[0].raw_affiliation_string | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[2].institutions[0].id | https://openalex.org/I111262870 |
| authorships[2].institutions[0].ror | https://ror.org/01azzms13 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I111262870 |
| authorships[2].institutions[0].country_code | ES |
| authorships[2].institutions[0].display_name | Universitat de Miguel Hernández d'Elx |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Alicia Medina-Peris |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[3].author.id | https://openalex.org/A5003767871 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6592-4373 |
| authorships[3].author.display_name | Tania Ciaglia |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I131729948 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I131729948 |
| authorships[3].institutions[0].ror | https://ror.org/0192m2k53 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I131729948 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | University of Salerno |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Tania Ciaglia |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[4].author.id | https://openalex.org/A5045526004 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Anton M. Novoselov |
| authorships[4].countries | RU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I19880235 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia |
| authorships[4].institutions[0].id | https://openalex.org/I19880235 |
| authorships[4].institutions[0].ror | https://ror.org/010pmpe69 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I19880235 |
| authorships[4].institutions[0].country_code | RU |
| authorships[4].institutions[0].display_name | Lomonosov Moscow State University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Anton M. Novoselov |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia |
| authorships[5].author.id | https://openalex.org/A5008024336 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9815-9866 |
| authorships[5].author.display_name | Andrea Altieri |
| authorships[5].countries | RU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I19880235 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia |
| authorships[5].affiliations[1].raw_affiliation_string | EDASA Scientific srls, Via Stingi 37, 66050 San Salvo, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I19880235 |
| authorships[5].institutions[0].ror | https://ror.org/010pmpe69 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I19880235 |
| authorships[5].institutions[0].country_code | RU |
| authorships[5].institutions[0].display_name | Lomonosov Moscow State University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Andrea Altieri |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia, EDASA Scientific srls, Via Stingi 37, 66050 San Salvo, Italy |
| authorships[6].author.id | https://openalex.org/A5005470954 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1133-0908 |
| authorships[6].author.display_name | David Cabañero |
| authorships[6].countries | ES |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I111262870 |
| authorships[6].affiliations[0].raw_affiliation_string | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[6].institutions[0].id | https://openalex.org/I111262870 |
| authorships[6].institutions[0].ror | https://ror.org/01azzms13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I111262870 |
| authorships[6].institutions[0].country_code | ES |
| authorships[6].institutions[0].display_name | Universitat de Miguel Hernández d'Elx |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | David Cabañero |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[7].author.id | https://openalex.org/A5071387984 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-2741-1427 |
| authorships[7].author.display_name | Asia Fernández‐Carvajal |
| authorships[7].countries | ES |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I111262870 |
| authorships[7].affiliations[0].raw_affiliation_string | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[7].institutions[0].id | https://openalex.org/I111262870 |
| authorships[7].institutions[0].ror | https://ror.org/01azzms13 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I111262870 |
| authorships[7].institutions[0].country_code | ES |
| authorships[7].institutions[0].display_name | Universitat de Miguel Hernández d'Elx |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Asia Fernandez-Carvajal |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, Avenida de la Universidad, 03202 Elche, Spain |
| authorships[8].author.id | https://openalex.org/A5074768676 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-1069-2181 |
| authorships[8].author.display_name | Pietro Campiglia |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I131729948 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I131729948 |
| authorships[8].institutions[0].ror | https://ror.org/0192m2k53 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I131729948 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | University of Salerno |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Pietro Campiglia |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[9].author.id | https://openalex.org/A5050246182 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6688-2606 |
| authorships[9].author.display_name | Isabel Gómez‐Monterrey |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I71267560 |
| authorships[9].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | University of Naples Federico II |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Isabel Gomez-Monterrey |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy |
| authorships[10].author.id | https://openalex.org/A5069089232 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-5482-6276 |
| authorships[10].author.display_name | Alessia Bertamino |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I131729948 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I131729948 |
| authorships[10].institutions[0].ror | https://ror.org/0192m2k53 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I131729948 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | University of Salerno |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Alessia Bertamino |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy |
| authorships[11].author.id | https://openalex.org/A5066173922 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-8467-9721 |
| authorships[11].author.display_name | Alexander V. Kurkin |
| authorships[11].countries | RU |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I19880235 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia |
| authorships[11].institutions[0].id | https://openalex.org/I19880235 |
| authorships[11].institutions[0].ror | https://ror.org/010pmpe69 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I19880235 |
| authorships[11].institutions[0].country_code | RU |
| authorships[11].institutions[0].display_name | Lomonosov Moscow State University |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Alexander V. Kurkin |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, 119991 Moscow, Russia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12356 |
| primary_topic.field.id | https://openalex.org/fields/30 |
| primary_topic.field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| primary_topic.score | 0.9991999864578247 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3005 |
| primary_topic.subfield.display_name | Toxicology |
| primary_topic.display_name | Bioactive Compounds and Antitumor Agents |
| related_works | https://openalex.org/W2138350991, https://openalex.org/W1566729005, https://openalex.org/W2409285845, https://openalex.org/W2434195791, https://openalex.org/W1994342570, https://openalex.org/W2562771455, https://openalex.org/W2054843986, https://openalex.org/W2116210813, https://openalex.org/W2440701365, https://openalex.org/W2433842723 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/ijms23042070 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms23042070 |
| primary_location.id | doi:10.3390/ijms23042070 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/23/4/2070/pdf?version=1644817358 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms23042070 |
| publication_date | 2022-02-13 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W3193034465, https://openalex.org/W2971947057, https://openalex.org/W2157174760, https://openalex.org/W2022293360, https://openalex.org/W2090617423, https://openalex.org/W1983420263, https://openalex.org/W3215968455, https://openalex.org/W2113737911, https://openalex.org/W1800213874, https://openalex.org/W2469250356, https://openalex.org/W2040008189, https://openalex.org/W2079158537, https://openalex.org/W2050264923, https://openalex.org/W2273419161, https://openalex.org/W2052502289, https://openalex.org/W2805064045, https://openalex.org/W1545168029, https://openalex.org/W3013007514, https://openalex.org/W3045631794, https://openalex.org/W2171575119, https://openalex.org/W2127420494, https://openalex.org/W2036189937, https://openalex.org/W2016761110, https://openalex.org/W3207943015, https://openalex.org/W2751150280, https://openalex.org/W2087665027, https://openalex.org/W2337718384, https://openalex.org/W2810796788, https://openalex.org/W3045599233, https://openalex.org/W2984697566, https://openalex.org/W3215963087, https://openalex.org/W3023126697, https://openalex.org/W3013834986, https://openalex.org/W3008751387, https://openalex.org/W2127140021, https://openalex.org/W2904128704, https://openalex.org/W2884548335, https://openalex.org/W2598062636, https://openalex.org/W2946938349, https://openalex.org/W2157581185, https://openalex.org/W2919443340, https://openalex.org/W2942149901, https://openalex.org/W6632564058, https://openalex.org/W2154139219, https://openalex.org/W2106882534, https://openalex.org/W2129153475, https://openalex.org/W2106383417, https://openalex.org/W2170598431, https://openalex.org/W2031168104, https://openalex.org/W2102377211, https://openalex.org/W1985588649, https://openalex.org/W2009423060, https://openalex.org/W2161350993, https://openalex.org/W1964613053, https://openalex.org/W2153228625, https://openalex.org/W2097775366, https://openalex.org/W2051381895, https://openalex.org/W1976499671, https://openalex.org/W2115211453, https://openalex.org/W3112376646 |
| referenced_works_count | 60 |
| abstract_inverted_index.8 | 5 |
| abstract_inverted_index.a | 8, 33, 43, 182 |
| abstract_inverted_index.30 | 190 |
| abstract_inverted_index.BB | 137 |
| abstract_inverted_index.To | 77 |
| abstract_inverted_index.as | 22, 118 |
| abstract_inverted_index.at | 189 |
| abstract_inverted_index.by | 158 |
| abstract_inverted_index.in | 57, 89, 179, 181 |
| abstract_inverted_index.is | 7, 54 |
| abstract_inverted_index.of | 13, 36, 46, 98, 122 |
| abstract_inverted_index.to | 30, 63, 66, 92, 105, 143, 204 |
| abstract_inverted_index.± | 173 |
| abstract_inverted_index.(BB | 134, 169 |
| abstract_inverted_index.The | 129, 152, 165, 193 |
| abstract_inverted_index.and | 28, 41, 72, 110, 136, 210 |
| abstract_inverted_index.are | 20 |
| abstract_inverted_index.for | 10, 25, 59, 149, 207 |
| abstract_inverted_index.has | 86 |
| abstract_inverted_index.key | 145 |
| abstract_inverted_index.low | 162 |
| abstract_inverted_index.new | 60, 194 |
| abstract_inverted_index.the | 11, 80, 107, 202 |
| abstract_inverted_index.two | 124, 153 |
| abstract_inverted_index.was | 176 |
| abstract_inverted_index.way | 203 |
| abstract_inverted_index.μM | 191 |
| abstract_inverted_index.0.26 | 174 |
| abstract_inverted_index.1.25 | 172 |
| abstract_inverted_index.Four | 114 |
| abstract_inverted_index.IC50 | 171 |
| abstract_inverted_index.also | 156 |
| abstract_inverted_index.been | 39, 87 |
| abstract_inverted_index.cold | 183 |
| abstract_inverted_index.date | 31 |
| abstract_inverted_index.drug | 208 |
| abstract_inverted_index.have | 38, 48 |
| abstract_inverted_index.high | 55 |
| abstract_inverted_index.most | 130, 166 |
| abstract_inverted_index.only | 32 |
| abstract_inverted_index.then | 177 |
| abstract_inverted_index.thus | 42 |
| abstract_inverted_index.type | 4 |
| abstract_inverted_index.used | 104 |
| abstract_inverted_index.vivo | 180 |
| abstract_inverted_index.were | 103, 116, 125, 155 |
| abstract_inverted_index.μM) | 175 |
| abstract_inverted_index.EDASA | 81 |
| abstract_inverted_index.Hence | 52 |
| abstract_inverted_index.TRPM8 | 18, 61, 120, 132 |
| abstract_inverted_index.While | 17 |
| abstract_inverted_index.clues | 65 |
| abstract_inverted_index.dose. | 192 |
| abstract_inverted_index.drugs | 24 |
| abstract_inverted_index.pain, | 26 |
| abstract_inverted_index.there | 53 |
| abstract_inverted_index.this, | 79 |
| abstract_inverted_index.value | 56 |
| abstract_inverted_index.which | 123 |
| abstract_inverted_index.TRPM8. | 99 |
| abstract_inverted_index.assays | 102 |
| abstract_inverted_index.assess | 111 |
| abstract_inverted_index.model, | 185 |
| abstract_inverted_index.number | 35, 45 |
| abstract_inverted_index.paving | 201 |
| abstract_inverted_index.potent | 131, 167 |
| abstract_inverted_index.showed | 197 |
| abstract_inverted_index.target | 9 |
| abstract_inverted_index.(TRPM8) | 6 |
| abstract_inverted_index.0322703 | 135 |
| abstract_inverted_index.Calcium | 100 |
| abstract_inverted_index.address | 78 |
| abstract_inverted_index.assays, | 160 |
| abstract_inverted_index.broaden | 64 |
| abstract_inverted_index.cancer, | 27 |
| abstract_inverted_index.explore | 73 |
| abstract_inverted_index.further | 205 |
| abstract_inverted_index.improve | 69 |
| abstract_inverted_index.leading | 91 |
| abstract_inverted_index.library | 85 |
| abstract_inverted_index.limited | 34, 44 |
| abstract_inverted_index.reached | 49 |
| abstract_inverted_index.showing | 186 |
| abstract_inverted_index.silico, | 90 |
| abstract_inverted_index.studies | 142 |
| abstract_inverted_index.trials. | 51 |
| abstract_inverted_index.0322703, | 170 |
| abstract_inverted_index.0322720) | 138 |
| abstract_inverted_index.clinical | 50 |
| abstract_inverted_index.compound | 112, 168 |
| abstract_inverted_index.efficacy | 188 |
| abstract_inverted_index.features | 147 |
| abstract_inverted_index.in-house | 83 |
| abstract_inverted_index.profiled | 178 |
| abstract_inverted_index.receptor | 1 |
| abstract_inverted_index.reported | 21 |
| abstract_inverted_index.screened | 88 |
| abstract_inverted_index.validate | 106 |
| abstract_inverted_index.Transient | 0 |
| abstract_inverted_index.allodinya | 184 |
| abstract_inverted_index.compounds | 47, 97, 115, 154 |
| abstract_inverted_index.different | 14 |
| abstract_inverted_index.discovery | 209 |
| abstract_inverted_index.highlight | 144 |
| abstract_inverted_index.in-silico | 108 |
| abstract_inverted_index.modelling | 141 |
| abstract_inverted_index.molecular | 75, 84, 140 |
| abstract_inverted_index.potential | 2, 23 |
| abstract_inverted_index.purposes. | 212 |
| abstract_inverted_index.searching | 58 |
| abstract_inverted_index.selective | 119 |
| abstract_inverted_index.treatment | 12 |
| abstract_inverted_index.underwent | 139 |
| abstract_inverted_index.Scientific | 82 |
| abstract_inverted_index.antagonist | 96 |
| abstract_inverted_index.chemotypes | 37, 195 |
| abstract_inverted_index.confirming | 161 |
| abstract_inverted_index.hypothesis | 109 |
| abstract_inverted_index.identified | 117, 196 |
| abstract_inverted_index.melastatin | 3 |
| abstract_inverted_index.micromolar | 163 |
| abstract_inverted_index.potencies. | 164 |
| abstract_inverted_index.processes. | 16 |
| abstract_inverted_index.properties | 71, 200 |
| abstract_inverted_index.remarkable | 198 |
| abstract_inverted_index.structural | 146 |
| abstract_inverted_index.twenty-one | 94 |
| abstract_inverted_index.underlying | 74 |
| abstract_inverted_index.TRPM8/TRPV1 | 127 |
| abstract_inverted_index.antagonists | 19, 133 |
| abstract_inverted_index.dual-acting | 126 |
| abstract_inverted_index.identifying | 93 |
| abstract_inverted_index.mechanisms. | 76 |
| abstract_inverted_index.modulators. | 128 |
| abstract_inverted_index.patch-clamp | 159 |
| abstract_inverted_index.potentially | 95 |
| abstract_inverted_index.responsible | 148 |
| abstract_inverted_index.antagonistic | 62 |
| abstract_inverted_index.antagonists, | 121 |
| abstract_inverted_index.fluorometric | 101 |
| abstract_inverted_index.interaction. | 151 |
| abstract_inverted_index.investigated | 40, 157 |
| abstract_inverted_index.selectivity. | 113 |
| abstract_inverted_index.inflammation, | 29 |
| abstract_inverted_index.drug–protein | 150 |
| abstract_inverted_index.investigations | 206 |
| abstract_inverted_index.relationships, | 68 |
| abstract_inverted_index.pharmacological | 70, 187, 199, 211 |
| abstract_inverted_index.structure-activity | 67 |
| abstract_inverted_index.physio-pathological | 15 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5069089232, https://openalex.org/A5066173922 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I131729948, https://openalex.org/I19880235 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.70037927 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |