In Vitro and In Vivo Translational Insights on the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections Article Swipe
Bartłomiej Dudek
,
Malwina Brożyna
,
Michał Karoluk
,
Mariusz Frankiewicz
,
Paweł Migdał
,
Konrad Szustakiewicz
,
Tomasz Matys
,
Adrian Wiater
,
Adam Junka
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202411.0308.v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202411.0308.v1
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study evaluates the in vitro effectiveness of antiseptic and lavage solutions—including polyhexanide, povidone-iodine, low-concentration hypochlorite, Ringer’s solution, and saline—against Staphylococcus epidermidis, Staphylococcus aureus MRSA, Cutibacterium acnes, Corynebacterium amycolatum, Pseudomonas aeruginosa, and Candida albicans. Using microplate models (Minimum Inhibitory Concentration, Minimum Biofilm Eradication Concentration, and Biofilm-Oriented Antiseptic Test assays), flow-based models (Bioflux system), and surfaces relevant to orthopedic implants (e.g., stainless steel disks/screws, Co-Cr-Mo, Ti-Al-Nb orthopedic alloys, and ultra-high molecular weight polyethylene), as well as a bio-nano-cellulose scaffold representing tissue, we assessed solutions activity. The cytotoxicity of the solutions was evaluated using osteoblast and keratinocyte cell lines, with additional in vivo insights gained through the Galleria mellonella larval model. Results show that polyhexanide-based solutions outperformed povidone-iodine in biofilm eradication in most tests applied, particularly on complex surfaces, whereas iodine demonstrated higher cytotoxicity in applied in vitro and in vivo tests. Low-concentration hypochlorite solutions exhibited minimal antibiofilm activity but also showed no cytotoxicity in cell line and G. mellonella larval models. These findings highlight the importance of careful antiseptic selection and rinsing protocols to balance infection control efficacy with tissue compatibility in orthopedic applications.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202411.0308.v1
- https://www.preprints.org/manuscript/202411.0308/v1/download
- OA Status
- green
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404092945
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404092945Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202411.0308.v1Digital Object Identifier
- Title
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In Vitro and In Vivo Translational Insights on the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic InfectionsWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-11-06Full publication date if available
- Authors
-
Bartłomiej Dudek, Malwina Brożyna, Michał Karoluk, Mariusz Frankiewicz, Paweł Migdał, Konrad Szustakiewicz, Tomasz Matys, Adrian Wiater, Adam JunkaList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202411.0308.v1Publisher landing page
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https://www.preprints.org/manuscript/202411.0308/v1/downloadDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
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https://www.preprints.org/manuscript/202411.0308/v1/downloadDirect OA link when available
- Concepts
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In vivo, Orthopedic surgery, In vitro, Microorganism, Medicine, Microbiology, Pharmacology, Chemistry, Surgery, Biology, Bacteria, Biotechnology, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.tissue, | 106 |
| abstract_inverted_index.whereas | 154 |
| abstract_inverted_index.(Bioflux | 78 |
| abstract_inverted_index.(Minimum | 64 |
| abstract_inverted_index.Galleria | 132 |
| abstract_inverted_index.Ti-Al-Nb | 91 |
| abstract_inverted_index.activity | 173 |
| abstract_inverted_index.applied, | 149 |
| abstract_inverted_index.assays), | 75 |
| abstract_inverted_index.assessed | 108 |
| abstract_inverted_index.control. | 26 |
| abstract_inverted_index.delivery | 21 |
| abstract_inverted_index.efficacy | 203 |
| abstract_inverted_index.findings | 188 |
| abstract_inverted_index.implants | 85 |
| abstract_inverted_index.insights | 128 |
| abstract_inverted_index.relevant | 82 |
| abstract_inverted_index.scaffold | 104 |
| abstract_inverted_index.surfaces | 81 |
| abstract_inverted_index.system), | 79 |
| abstract_inverted_index.Co-Cr-Mo, | 90 |
| abstract_inverted_index.activity. | 110 |
| abstract_inverted_index.albicans. | 60 |
| abstract_inverted_index.evaluated | 117 |
| abstract_inverted_index.evaluates | 29 |
| abstract_inverted_index.exhibited | 170 |
| abstract_inverted_index.following | 9 |
| abstract_inverted_index.highlight | 189 |
| abstract_inverted_index.infection | 25, 201 |
| abstract_inverted_index.localized | 17 |
| abstract_inverted_index.molecular | 96 |
| abstract_inverted_index.protocols | 198 |
| abstract_inverted_index.selection | 195 |
| abstract_inverted_index.solution, | 44 |
| abstract_inverted_index.solutions | 109, 115, 140, 169 |
| abstract_inverted_index.stainless | 87 |
| abstract_inverted_index.surfaces, | 153 |
| abstract_inverted_index.surgeries | 11 |
| abstract_inverted_index.Antiseptic | 73 |
| abstract_inverted_index.Inhibitory | 65 |
| abstract_inverted_index.Ringer’s | 43 |
| abstract_inverted_index.additional | 125 |
| abstract_inverted_index.antibiotic | 2 |
| abstract_inverted_index.antiseptic | 18, 35, 194 |
| abstract_inverted_index.flow-based | 76 |
| abstract_inverted_index.importance | 191 |
| abstract_inverted_index.infections | 8 |
| abstract_inverted_index.mellonella | 133, 184 |
| abstract_inverted_index.microplate | 62 |
| abstract_inverted_index.orthopedic | 10, 84, 92, 208 |
| abstract_inverted_index.osteoblast | 119 |
| abstract_inverted_index.resistance | 3 |
| abstract_inverted_index.ultra-high | 95 |
| abstract_inverted_index.Eradication | 69 |
| abstract_inverted_index.Pseudomonas | 56 |
| abstract_inverted_index.aeruginosa, | 57 |
| abstract_inverted_index.amycolatum, | 55 |
| abstract_inverted_index.antibiofilm | 172 |
| abstract_inverted_index.eradication | 145 |
| abstract_inverted_index.underscores | 12 |
| abstract_inverted_index.cytotoxicity | 112, 158, 178 |
| abstract_inverted_index.demonstrated | 156 |
| abstract_inverted_index.epidermidis, | 48 |
| abstract_inverted_index.hypochlorite | 168 |
| abstract_inverted_index.keratinocyte | 121 |
| abstract_inverted_index.outperformed | 141 |
| abstract_inverted_index.particularly | 150 |
| abstract_inverted_index.representing | 105 |
| abstract_inverted_index.Cutibacterium | 52 |
| abstract_inverted_index.applications. | 209 |
| abstract_inverted_index.compatibility | 206 |
| abstract_inverted_index.disks/screws, | 89 |
| abstract_inverted_index.effectiveness | 33 |
| abstract_inverted_index.hypochlorite, | 42 |
| abstract_inverted_index.polyhexanide, | 39 |
| abstract_inverted_index.postoperative | 7 |
| abstract_inverted_index.Concentration, | 66, 70 |
| abstract_inverted_index.Staphylococcus | 47, 49 |
| abstract_inverted_index.microorganisms | 5 |
| abstract_inverted_index.polyethylene), | 98 |
| abstract_inverted_index.Corynebacterium | 54 |
| abstract_inverted_index.povidone-iodine | 142 |
| abstract_inverted_index.Biofilm-Oriented | 72 |
| abstract_inverted_index.povidone-iodine, | 40 |
| abstract_inverted_index.saline—against | 46 |
| abstract_inverted_index.Low-concentration | 167 |
| abstract_inverted_index.low-concentration | 41 |
| abstract_inverted_index.bio-nano-cellulose | 103 |
| abstract_inverted_index.polyhexanide-based | 139 |
| abstract_inverted_index.solutions—including | 38 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.76802183 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |