In Vitro Anti-Inflammatory Activity of Methyl Derivatives of Flavanone Article Swipe
Małgorzata Kłósek
,
Agnieszka Krawczyk-Łebek
,
Edyta Kostrzewa-Susłow
,
Ewelina Szliszka
,
Joanna Bronikowska
,
Dagmara Jaworska
,
Grażyna Pietsz
,
Zenon Czuba
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28237837
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28237837
Inflammation plays an important role in the immune defense against injury and infection agents. However, the inflammatory chronic process may lead to neurodegenerative diseases, atherosclerosis, inflammatory bowel diseases, or cancer. Flavanones present in citrus fruits exhibit biological activities, including anti-oxidative and anti-inflammatory properties. The beneficial effects of flavanones have been found based on in vitro cell cultures and animal studies. A suitable in vitro model for studying the inflammatory process are macrophages (RAW264.7 cell line) because, after stimulation using lipopolysaccharide (LPS), they release inflammatory cytokines involved in the immune response. We determined the nitrite concentration in the macrophage cell culture and detected ROS using chemiluminescence. Additionally, we measured the production of selected cytokines using the Bio-Plex Magnetic Luminex Assay and the Bio-PlexTM 200 System. For the first time, we have shown that methyl derivatives of flavanone inhibit NO and chemiluminescence generated via LPS-stimulated macrophages. Moreover, the tested compounds at 1–20 µM dose-dependently modulate proinflammatory cytokine production (IL-1β, IL-6, IL-12p40, IL-12p70, and TNF-α) in stimulated RAW264.7 cells. The 2′-methylflavanone (5B) and the 3′-methylflavanone (6B) possess the strongest anti-inflammatory activity among all the tested flavanone derivatives. These compounds reduce the concentration of IL-6, IL-12p40, and IL12p70 compared to the core flavanone structure. Moreover, 2′-methylflavanone reduces TNF-α, and 3′-methylflavanone reduces IL-1β secreted by RAW264.7 cells.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules28237837
- https://www.mdpi.com/1420-3049/28/23/7837/pdf?version=1701244706
- OA Status
- gold
- Cited By
- 11
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389145708
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389145708Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules28237837Digital Object Identifier
- Title
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In Vitro Anti-Inflammatory Activity of Methyl Derivatives of FlavanoneWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-11-29Full publication date if available
- Authors
-
Małgorzata Kłósek, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow, Ewelina Szliszka, Joanna Bronikowska, Dagmara Jaworska, Grażyna Pietsz, Zenon CzubaList of authors in order
- Landing page
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https://doi.org/10.3390/molecules28237837Publisher landing page
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https://www.mdpi.com/1420-3049/28/23/7837/pdf?version=1701244706Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/28/23/7837/pdf?version=1701244706Direct OA link when available
- Concepts
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Flavanone, In vitro, Chemistry, Anti-inflammatory, Pharmacology, Flavonoid, Stereochemistry, Biochemistry, Traditional medicine, Biology, Medicine, AntioxidantTop concepts (fields/topics) attached by OpenAlex
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-
11Total citation count in OpenAlex
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2025: 7, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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55Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.using | 78, 103, 113 |
| abstract_inverted_index.vitro | 54, 63 |
| abstract_inverted_index.(LPS), | 80 |
| abstract_inverted_index.1–20 | 149 |
| abstract_inverted_index.IL-1β | 207 |
| abstract_inverted_index.animal | 58 |
| abstract_inverted_index.cells. | 165, 211 |
| abstract_inverted_index.citrus | 33 |
| abstract_inverted_index.fruits | 34 |
| abstract_inverted_index.immune | 7, 88 |
| abstract_inverted_index.injury | 10 |
| abstract_inverted_index.methyl | 132 |
| abstract_inverted_index.reduce | 186 |
| abstract_inverted_index.tested | 146, 181 |
| abstract_inverted_index.IL12p70 | 193 |
| abstract_inverted_index.Luminex | 117 |
| abstract_inverted_index.System. | 123 |
| abstract_inverted_index.TNF-α) | 161 |
| abstract_inverted_index.TNF-α, | 203 |
| abstract_inverted_index.against | 9 |
| abstract_inverted_index.agents. | 13 |
| abstract_inverted_index.cancer. | 29 |
| abstract_inverted_index.chronic | 17 |
| abstract_inverted_index.culture | 99 |
| abstract_inverted_index.defense | 8 |
| abstract_inverted_index.effects | 45 |
| abstract_inverted_index.exhibit | 35 |
| abstract_inverted_index.inhibit | 136 |
| abstract_inverted_index.nitrite | 93 |
| abstract_inverted_index.possess | 173 |
| abstract_inverted_index.present | 31 |
| abstract_inverted_index.process | 18, 69 |
| abstract_inverted_index.reduces | 202, 206 |
| abstract_inverted_index.release | 82 |
| abstract_inverted_index.(IL-1β, | 156 |
| abstract_inverted_index.Bio-Plex | 115 |
| abstract_inverted_index.However, | 14 |
| abstract_inverted_index.Magnetic | 116 |
| abstract_inverted_index.RAW264.7 | 164, 210 |
| abstract_inverted_index.activity | 177 |
| abstract_inverted_index.because, | 75 |
| abstract_inverted_index.compared | 194 |
| abstract_inverted_index.cultures | 56 |
| abstract_inverted_index.cytokine | 154 |
| abstract_inverted_index.detected | 101 |
| abstract_inverted_index.involved | 85 |
| abstract_inverted_index.measured | 107 |
| abstract_inverted_index.modulate | 152 |
| abstract_inverted_index.secreted | 208 |
| abstract_inverted_index.selected | 111 |
| abstract_inverted_index.studies. | 59 |
| abstract_inverted_index.studying | 66 |
| abstract_inverted_index.suitable | 61 |
| abstract_inverted_index.(RAW264.7 | 72 |
| abstract_inverted_index.IL-12p40, | 158, 191 |
| abstract_inverted_index.IL-12p70, | 159 |
| abstract_inverted_index.Moreover, | 144, 200 |
| abstract_inverted_index.compounds | 147, 185 |
| abstract_inverted_index.cytokines | 84, 112 |
| abstract_inverted_index.diseases, | 23, 27 |
| abstract_inverted_index.flavanone | 135, 182, 198 |
| abstract_inverted_index.generated | 140 |
| abstract_inverted_index.important | 3 |
| abstract_inverted_index.including | 38 |
| abstract_inverted_index.infection | 12 |
| abstract_inverted_index.response. | 89 |
| abstract_inverted_index.strongest | 175 |
| abstract_inverted_index.Bio-PlexTM | 121 |
| abstract_inverted_index.Flavanones | 30 |
| abstract_inverted_index.beneficial | 44 |
| abstract_inverted_index.biological | 36 |
| abstract_inverted_index.determined | 91 |
| abstract_inverted_index.flavanones | 47 |
| abstract_inverted_index.macrophage | 97 |
| abstract_inverted_index.production | 109, 155 |
| abstract_inverted_index.stimulated | 163 |
| abstract_inverted_index.structure. | 199 |
| abstract_inverted_index.activities, | 37 |
| abstract_inverted_index.derivatives | 133 |
| abstract_inverted_index.macrophages | 71 |
| abstract_inverted_index.properties. | 42 |
| abstract_inverted_index.stimulation | 77 |
| abstract_inverted_index.Inflammation | 0 |
| abstract_inverted_index.derivatives. | 183 |
| abstract_inverted_index.inflammatory | 16, 25, 68, 83 |
| abstract_inverted_index.macrophages. | 143 |
| abstract_inverted_index.Additionally, | 105 |
| abstract_inverted_index.concentration | 94, 188 |
| abstract_inverted_index.LPS-stimulated | 142 |
| abstract_inverted_index.anti-oxidative | 39 |
| abstract_inverted_index.proinflammatory | 153 |
| abstract_inverted_index.atherosclerosis, | 24 |
| abstract_inverted_index.dose-dependently | 151 |
| abstract_inverted_index.anti-inflammatory | 41, 176 |
| abstract_inverted_index.chemiluminescence | 139 |
| abstract_inverted_index.neurodegenerative | 22 |
| abstract_inverted_index.chemiluminescence. | 104 |
| abstract_inverted_index.lipopolysaccharide | 79 |
| abstract_inverted_index.2′-methylflavanone | 167, 201 |
| abstract_inverted_index.3′-methylflavanone | 171, 205 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5029059476 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I166182418, https://openalex.org/I864159182 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.80573828 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |