In Vitro Differentiation of Bone Marrow Mesenchymal Stem Cells into Neuron-Like Cells by Cerebrospinal Fluid Improves Motor Function of Middle Cerebral Artery Occlusion Rats Article Swipe
Ying Ye
,
Yiran Peng
,
Shuqun Hu
,
Xianliang Yan
,
Juan Chen
,
Tie Xu
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2016.00183
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2016.00183
Bone marrow mesenchymal stem cells (BMSCs) represent a promising tool for stem cell-based therapies. However, the majority of BMSC transplants only allow for limited recovery of the lost functions. We previously found that human cerebrospinal fluid (hCSF) is more potent than growth factors in differentiating human BMSCs into neuron-like cells in vitro. In this study, we studied the effect of transplantation of rat BMSC-derived neuron-like cells (BMSC-Ns) induced by hCSF into rat brain with middle cerebral artery occlusion (MCAO). The survival and differentiation of the transplanted cells were determined using immunofluorescence staining of bromodeoxyuridine. The recovery of neurological function were observed by the modified neurological severity score (modified NSS) at 4, 15, and 32 days after cell transplantation, HE staining for determination of the infarct volume at day 32 after cell transplantation. Transplantation of BMSC-Ns or BMSCs significantly improved indexes of neurological function and reduced infarct size in rats previously subjected to MCAO compared with those in the control group. Remarkably, 32 days after transplantation, rats treated with BMSC-Ns presented a smaller infarct size, higher number of neuron-specific, enolase-positive, and BrdU-positive cells, and improved neurological function compared with BMSC group. Our results demonstrate that transplantation of hCSF-treated BMSC-Ns significantly improves neurological function and reduces infarct size in rats subjected to MCAO. This study may pave a new avenue for the treatment of MCAO.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2016.00183
- https://www.frontiersin.org/articles/10.3389/fneur.2016.00183/pdf
- OA Status
- gold
- Cited By
- 14
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2542923303
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2542923303Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fneur.2016.00183Digital Object Identifier
- Title
-
In Vitro Differentiation of Bone Marrow Mesenchymal Stem Cells into Neuron-Like Cells by Cerebrospinal Fluid Improves Motor Function of Middle Cerebral Artery Occlusion RatsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-10-27Full publication date if available
- Authors
-
Ying Ye, Yiran Peng, Shuqun Hu, Xianliang Yan, Juan Chen, Tie XuList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2016.00183Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fneur.2016.00183/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fneur.2016.00183/pdfDirect OA link when available
- Concepts
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Transplantation, Mesenchymal stem cell, Medicine, Stem cell, Pathology, Bone marrow, Neuron, Ischemia, Enolase, Biology, Internal medicine, Immunohistochemistry, Cell biology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2023: 3, 2022: 2, 2021: 1, 2020: 1, 2019: 3Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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