In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis Article Swipe
Mario Codreanu
,
Diana Iacob
,
Maria Ioana Onofrei
,
Ana-Maria Vlase
,
Dana-Maria Muntean
,
Laurian Vlase
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.24193/subbchem.2024.4.13
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.24193/subbchem.2024.4.13
This study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models. In vitro dissolution tests were conducted in three pH media (1.2, 4.5, and 6.8) to simulate various gastrointestinal conditions. Data was collected under fed conditions from a bioequivalence (BE) study. The modeling and calculations were performed using Phoenix WinNonlin® version 8.4 software, enabling estimation of drug absorption kinetics. A Level A IVIVC model was employed for each in vivo data to establish a direct and reliable correlation between the in vitro dissolution profiles and the in vivo pharmacokinetic data. The determination coefficient (R²) exceeded 0.97, demonstrating a high degree of predictability and robustness in the established IVIVC.
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- OA Status
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https://openalex.org/W4406310649Canonical identifier for this work in OpenAlex
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https://doi.org/10.24193/subbchem.2024.4.13Digital Object Identifier
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In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic AnalysisWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-12-18Full publication date if available
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Mario Codreanu, Diana Iacob, Maria Ioana Onofrei, Ana-Maria Vlase, Dana-Maria Muntean, Laurian VlaseList of authors in order
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https://doi.org/10.24193/subbchem.2024.4.13Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.24193/subbchem.2024.4.13Direct OA link when available
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Pentoxifylline, In vivo, In vitro, Chemistry, Kinetic energy, Pharmacology, Medicine, Biology, Biochemistry, Physics, Quantum mechanics, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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