In Vitro Salivary Protein Adsorption Profile on Titanium and Ceramic Surfaces and the Corresponding Putative Immunological Implications Article Swipe
Chenxuan Wei
,
Michael F. Burrow
,
Michael G. Botelho
,
Henry Lam
,
WK Leung
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21093083
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21093083
Immune responses triggered by implant abutment surfaces contributed by surface-adsorbed proteins are critical in clinical implant integration. How material surface-adsorbed proteins relate to host immune responses remain unclear. This study aimed to profile and address the immunological roles of surface-adsorbed salivary proteins on conventional implant abutment materials. Standardized polished bocks (5 × 5 × 1 mm3) were prepared from titanium and feldspathic ceramic. Salivary acquired pellicle formed in vitro was examined by liquid chromatography-tandem mass spectrometry and gene ontology (GO) analysis to identify and characterize the adsorbed proteins. Out of 759 proteins identified from pooled saliva samples, 396 were found to be attached to the two materials tested—369 on titanium and 298 on ceramic, with 281 common to both. GO annotation of immune processes was undertaken to form a protein–protein interaction network, and 14 hub proteins (≥6 interaction partners) (coding genes: B2M, C3, CLU, DEFA1, HSP90AA1, HSP90AB1, LTF, PIGR, PSMA2, RAC1, RAP1A, S100A8, S100A9, and SLP1) were identified as the key proteins connecting multiple (6–9) immune processes. The results offered putative immunological prospects of implant abutment material surface-adsorbed salivary proteins, which could potentially underpin the dynamic nature of implant–mucosal/implant–microbial interactions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms21093083
- https://www.mdpi.com/1422-0067/21/9/3083/pdf?version=1588166739
- OA Status
- gold
- Cited By
- 12
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3020769211
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3020769211Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms21093083Digital Object Identifier
- Title
-
In Vitro Salivary Protein Adsorption Profile on Titanium and Ceramic Surfaces and the Corresponding Putative Immunological ImplicationsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-27Full publication date if available
- Authors
-
Chenxuan Wei, Michael F. Burrow, Michael G. Botelho, Henry Lam, WK LeungList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms21093083Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/21/9/3083/pdf?version=1588166739Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/21/9/3083/pdf?version=1588166739Direct OA link when available
- Concepts
-
Protein adsorption, Implant, Adsorption, Saliva, Titanium, Immune system, Biology, Materials science, Chemistry, Biochemistry, Immunology, Medicine, Metallurgy, Organic chemistry, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 3, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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68Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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